B-cell growth factor-induced and alpha-interferon-inhibited proliferation of hairy cells coincides with modulation of cell surface antigens.

abstract：:The biochemical and clinical effects of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Sprague-Dawley rats are presented. A 4-ppm selenium supplement to the drinking water was provided before, during, and after 20 weekly injections of 20 mg DMH per kg body weight. Immediately af...

journal_title：Cancer research

authors： Jacobs MM,Forst CF,Beams FA

更新日期：1981-11-01 00:00:00

abstract：:The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription. There is evidence that three common polymorphisms of the XPD gene (C156A, Asp312Asn, and Lys751Gln) may be associated with differential DNA repair activity. Because increased DNA repair pl...

journal_title：Cancer research

authors： Park DJ,Stoehlmacher J,Zhang W,Tsao-Wei DD,Groshen S,Lenz HJ

更新日期：2001-12-15 00:00:00

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:The early cellular and molecular changes in the Solt-Farber model of hepatocarcinogenesis with and without initiation was studied by using histochemical, immunohistochemical, and in situ hybridization techniques. Increased cellularity was observed in the periductal space in both models 32 to 56 h after partial hepatec...

journal_title：Cancer research

authors： Evarts RP,Nakatsukasa H,Marsden ER,Hsia CC,Dunsford HA,Thorgeirsson SS

更新日期：1990-06-01 00:00:00

abstract：:Cultures of adult mouse epidermal keratinocytes (MEKs) were utilized to determine whether the metabolism and metabolic activation of polycyclic aromatic hydrocarbons varied as a function of extracellular calcium (Ca2+) concentration. MEKs grown in low Ca2+-containing medium (0.05-0.10 mM) maintain basal cell morpholog...

journal_title：Cancer research

authors： DiGiovanni J,Gill RD,Nettikumara AN,Colby AB,Reiners JJ Jr

更新日期：1989-10-15 00:00:00

abstract：:The purpose of this study was to characterize the transport properties of trimetrexate in WI-L2 human lymphoblastoid cells and determine the mode of resistance that had developed in a subline, WI-L2/TMQ, that was grown in increasing concentrations of trimetrexate. WI-L2/TMQ cells were 62-fold resistant to trimetrexate...

journal_title：Cancer research

authors： Fry DW,Besserer JA

更新日期：1988-12-15 00:00:00

abstract：:In recent years, there has been increasing recognition of the importance of steroid aromatization in organs besides the steroidogenic ones. Estrogens formed from C-19 precursors in peripheral tissues can clearly contribute to the levels of estrogens in the circulation, while aromatization in target cells may be an imp...

journal_title：Cancer research

authors： Weisz J

更新日期：1982-08-01 00:00:00

abstract：:Available evidence suggests that, among hematological malignancies, p53 is most often mutated in Burkitt's lymphoma (BL). However, much of the published data is based on cell lines. We have, therefore, analyzed BL biopsies to determine more accurately the frequency and pattern of p53 mutations in primary tumors and to...

journal_title：Cancer research

authors： Bhatia KG,Gutiérrez MI,Huppi K,Siwarski D,Magrath IT

更新日期：1992-08-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the identification of a...

journal_title：Cancer research

authors： Kim DJ,Roh E,Lee MH,Oi N,Lim DY,Kim MO,Cho YY,Pugliese A,Shim JH,Chen H,Cho EJ,Kim JE,Kang SC,Paul S,Kang HE,Jung JW,Lee SY,Kim SH,Reddy K,Yeom YI,Bode AM,Dong Z

更新日期：2016-03-01 00:00:00

abstract：:Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of the transcription ...

journal_title：Cancer research

authors： Bracken CP,Gregory PA,Kolesnikoff N,Bert AG,Wang J,Shannon MF,Goodall GJ

更新日期：2008-10-01 00:00:00

abstract：:Our recent allelic analysis of head and neck squamous cell carcinomas identified a high incidence of chromosomal loss on 13q. To further define an area of minimal loss, we tested 60 primary head and neck squamous cell carcinomas in 59 patients for loss of heterozygosity (LOH) by using 10 polymorphic microsatellite mar...

journal_title：Cancer research

authors： Yoo GH,Xu HJ,Brennan JA,Westra W,Hruban RH,Koch W,Benedict WF,Sidransky D

更新日期：1994-09-01 00:00:00

abstract：:Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirab...

journal_title：Cancer research

authors： Gao L,Michel A,Weck MN,Arndt V,Pawlita M,Brenner H

更新日期：2009-08-01 00:00:00

abstract：:Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and resistance to imatinib mesylate treatment remain poorly investigated. Here, we report that CD34(+) progenitors from patients with CML at di...

journal_title：Cancer research

authors： Levescot A,Flamant S,Basbous S,Jacomet F,Féraud O,Anne Bourgeois E,Bonnet ML,Giraud C,Roy L,Barra A,Chomel JC,Turhan A,Guilhot F,Girard JP,Gombert JM,Herbelin A

更新日期：2014-05-15 00:00:00

abstract：:Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-ind...

journal_title：Cancer research

authors： Sun M,Veschi V,Bagchi S,Xu M,Mendoza A,Liu Z,Thiele CJ

更新日期：2019-10-01 00:00:00

abstract：:Loss of p53 function has been shown to cause increased resistance to ionizing radiation in normal murine cells; however, the role of p53 in radioresistance of human tumor cells is less clear. Since wild-type p53 function is required for radiation-induced G1 arrest, we measured G1 arrest in 12 human tumor cell lines th...

journal_title：Cancer research

authors： McIlwrath AJ,Vasey PA,Ross GM,Brown R

更新日期：1994-07-15 00:00:00

abstract：:Earlier studies (Baeckström et al., J. Biol. Chem., 266: 21537-21547, 1991) have revealed that the colon carcinoma cell line COLO 205 produces two different proteins carrying the carcinoma-associated sialyl-Le(a) carbohydrate epitope. One is the MUC1 mucin apoprotein, and the other protein is smaller and has not been ...

journal_title：Cancer research

authors： Baeckström D,Nilsson O,Price MR,Lindholm L,Hansson GC

更新日期：1993-02-15 00:00:00

abstract：:Identification of proteins that are involved in the sensitivity of radiotherapy of cancers is important to enhance the response to cancer treatment. Expression of TAp73 is associated with the sensitivity of radiotherapy in cervical cancer patients, suggesting it plays an important role in controlling radiosensitivity....

journal_title：Cancer research

authors： Leung TH,Ngan HY

更新日期：2010-08-15 00:00:00

abstract：:Eph tyrosine kinases instruct cell for a repulsive behavior, regulating cell shape, adhesion, and motility. Beside its role during embryogenesis, neurogenesis, and angiogenesis, EphA2 kinase is frequently up-regulated in tumor cells of different histotypes, including prostate, breast, colon, and lung carcinoma, as wel...

journal_title：Cancer research

authors： Parri M,Taddei ML,Bianchini F,Calorini L,Chiarugi P

更新日期：2009-03-01 00:00:00

abstract：:Epithelioid sarcoma is a rare soft tissue neoplasm of uncertain lineage that usually arises in the distal extremities of adults, presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas. The recently reported large-cell "proximal-type" variant is characterized by increased aggressive...

journal_title：Cancer research

authors： Modena P,Lualdi E,Facchinetti F,Galli L,Teixeira MR,Pilotti S,Sozzi G

更新日期：2005-05-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:Shedding of tumor cell gangliosides may contribute to tumor cell escape from host immune destruction. Thus, it would be of interest to block the shedding of these immunosuppressive molecules. To this end, we studied a ceramide analogue, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). D-PDMP is a pot...

journal_title：Cancer research

authors： Li R,Ladisch S

更新日期：1996-10-15 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00

abstract：:We analyzed the gene expression profiles of clinical lung carcinomas using a cDNA microarray containing 27,648 genes or expressed sequence tags, and identified CDCA5 (cell division cycle associated 5) to be upregulated in the majority of lung cancers. Tumor tissue microarray analysis of 262 non-small cell lung cancer ...

journal_title：Cancer research

authors： Nguyen MH,Koinuma J,Ueda K,Ito T,Tsuchiya E,Nakamura Y,Daigo Y

更新日期：2010-07-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:A series of rat 13762NF mammary adenocarcinoma cell clones and subclones of various lung metastatic potentials were examined for their abilities to degrade rat lung subendothelial matrix and purified basement membrane type IV collagen. Metastatic potentials were simultaneously determined based on the ability to form "...

journal_title：Cancer research

authors： Nakajima M,Welch DR,Belloni PN,Nicolson GL

更新日期：1987-09-15 00:00:00

abstract：:Structural alterations of the p53 gene were investigated in tissue specimens of gastric and cervical cancers and in cell lines of gastric, esophageal, and cervical cancers, by polymerase chain reaction-single-strand conformation polymorphism analysis. Two of the four gastric cancer metastases and four of the eight cel...

journal_title：Cancer research

authors： Yamada Y,Yoshida T,Hayashi K,Sekiya T,Yokota J,Hirohashi S,Nakatani K,Nakano H,Sugimura T,Terada M

更新日期：1991-11-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:The chemokine receptor, CXCR4, is expressed by human melanomas, and its ligand, CXCL12, is frequently produced at sites of melanoma metastasis. Herein, we examine CXCR4-enhanced binding of B16 murine melanoma cells to endothelial cells (ECs) and recombinant adhesion molecules in vitro to determine the role of tumor- a...

journal_title：Cancer research

authors： Cardones AR,Murakami T,Hwang ST

更新日期：2003-10-15 00:00:00

abstract：:Resistance of tumors to irradiation or chemotherapeutic agents is thought to be one of the reasons why patients who present with early malignancies may not be cured. Much is now known about the molecular mechanisms that underlie drug resistance, but until recently little was known about genetic contributions to radiat...

journal_title：Cancer research

authors： McKenna WG,Weiss MC,Endlich B,Ling CC,Bakanauskas VJ,Kelsten ML,Muschel RJ

更新日期：1990-01-01 00:00:00