SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas.

abstract：:As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes to the lung, and induces a nonspecific immunosuppression in the host. Using this breast medullar adenocarcinoma model, a therapy consisting of a single moderat...

journal_title：Cancer research

authors： Ewens A,Luo L,Berleth E,Alderfer J,Wollman R,Hafeez BB,Kanter P,Mihich E,Ehrke MJ

更新日期：2006-05-15 00:00:00

abstract：:Previous data on the effects of a single dose of hydroxyurea on C3H mouse duodenum and mammary tumors from a fast growing line (S102F) were used to predict times that may be optimal (i.e., minimize killing of the duodenal S-phase cells while enhancing the killing of tumor S-phase cells) for the administration of subse...

journal_title：Cancer research

authors： Dethlefsen LA,Sorensen SP,Riley RM

更新日期：1975-03-01 00:00:00

abstract：:Altered DNA methylation is a key feature of cancer, and aberrant methylation is important in nasopharyngeal carcinoma (NPC) development. However, the methylation mechanisms underlying metastasis of NPC remain unclear. Analyzing data from public databases and conducting our own experiments, we report here that promoter...

journal_title：Cancer research

authors： Zhang J,Li YQ,Guo R,Wang YQ,Zhang PP,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

更新日期：2019-02-15 00:00:00

abstract：:We applied 1H-decoupling and nuclear Overhauser enhancement to obtain well-resolved 31P magnetic resonance spectra accurately localized to 20 soft tissue sarcomas in vivo, using three-dimensional chemical shift imaging. Fifteen spectra had large phosphomonoester signals (21% of total phosphorus) that contained high am...

journal_title：Cancer research

authors： Li CW,Kuesel AC,Padavic-Shaller KA,Murphy-Boesch J,Eisenberg BL,Schmidt RG,von Roemeling RW,Patchefsky AS,Brown TR,Negendank WG

更新日期：1996-07-01 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:Metastases from prostatic adenocarcinoma (prostate cancer) are characterized by their predilection for bone and typical osteoblastic features. An in vitro model of bone metastases from prostate cancer was developed using a bicompartment coculture system of mouse osteoblasts and human prostate cancer cells. In this mod...

journal_title：Cancer research

authors： Yang J,Fizazi K,Peleg S,Sikes CR,Raymond AK,Jamal N,Hu M,Olive M,Martinez LA,Wood CG,Logothetis CJ,Karsenty G,Navone NM

更新日期：2001-07-15 00:00:00

abstract：:Neuroblastoma is a neural crest-derived embryonal malignancy, which accounts for 13% of all pediatric cancer mortality, primarily due to tumor recurrence. Therapy-resistant cancer stem cells are implicated in tumor relapse, but definitive phenotypic evidence of the existence of these cells has been lacking. In this st...

journal_title：Cancer research

authors： Hsu DM,Agarwal S,Benham A,Coarfa C,Trahan DN,Chen Z,Stowers PN,Courtney AN,Lakoma A,Barbieri E,Metelitsa LS,Gunaratne P,Kim ES,Shohet JM

更新日期：2013-07-01 00:00:00

abstract：:The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures performed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell fac...

journal_title：Cancer research

authors： Berdel WE,de Vos S,Maurer J,Oberberg D,von Marschall Z,Schroeder JK,Li J,Ludwig WD,Kreuser ED,Thiel E

更新日期：1992-06-15 00:00:00

abstract：:Mutation in either TSC1 or TSC2 causes the autosomal dominant disorder tuberous sclerosis, in which widespread hamartomas are seen, some of which have a high level of vascularization. Tuberous sclerosis complex (TSC) gene products negatively regulate mammalian target of rapamycin (mTOR) activity. We found that vascula...

journal_title：Cancer research

authors： El-Hashemite N,Walker V,Zhang H,Kwiatkowski DJ

更新日期：2003-09-01 00:00:00

abstract：:Mechanisms for bladder carcinogenesis and the development of recurrentbladder cancer remain unclear. Aberrant methylation of the 5' CpG island is thought to play an important role in the inactivation of the tumor suppressor genes in cancer. To study whether specific or bulk hypermethylation predicts intrabladder recur...

journal_title：Cancer research

authors： Tada Y,Wada M,Taguchi K,Mochida Y,Kinugawa N,Tsuneyoshi M,Naito S,Kuwano M

更新日期：2002-07-15 00:00:00

abstract：:Antibodies were produced against 220,000-molecular-weight proteins of Syrian hamster embryo cells. The antiserum containing these antibodies is capable of immunologically staining the surfaces and a fibrillar network around untransformed Syrian hamster embryo cells. The staining is removed by adsorption of the antiser...

journal_title：Cancer research

authors： Clarke SM,Fink LM

更新日期：1977-09-01 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:N-2-(Diethylaminoethyl)-9-hydroxyellipticinium chloride (DHE) is a structural analogue of ellipticine that is currently a leading compound for clinical trials. We have investigated the mechanism of DNA damage by this compound in murine L1210 leukemia cells using the method of alkaline elution. Although DHE was about 1...

journal_title：Cancer research

authors： Djuric Z,Everett CK,Valeriote FA

更新日期：1992-03-15 00:00:00

abstract：:Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present...

journal_title：Cancer research

authors： Allen JK,Armaiz-Pena GN,Nagaraja AS,Sadaoui NC,Ortiz T,Dood R,Ozcan M,Herder DM,Haemmerle M,Gharpure KM,Rupaimoole R,Previs RA,Wu SY,Pradeep S,Xu X,Han HD,Zand B,Dalton HJ,Taylor M,Hu W,Bottsford-Miller J,Moreno

更新日期：2018-06-15 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and cont...

journal_title：Cancer research

authors： Serra V,Markman B,Scaltriti M,Eichhorn PJ,Valero V,Guzman M,Botero ML,Llonch E,Atzori F,Di Cosimo S,Maira M,Garcia-Echeverria C,Parra JL,Arribas J,Baselga J

更新日期：2008-10-01 00:00:00

abstract：:The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription. There is evidence that three common polymorphisms of the XPD gene (C156A, Asp312Asn, and Lys751Gln) may be associated with differential DNA repair activity. Because increased DNA repair pl...

journal_title：Cancer research

authors： Park DJ,Stoehlmacher J,Zhang W,Tsao-Wei DD,Groshen S,Lenz HJ

更新日期：2001-12-15 00:00:00

abstract：:T-cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8+ T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major...

journal_title：Cancer research

authors： Zhao Y,Ting KK,Li J,Cogger VC,Chen J,Johansson-Percival A,Ngiow SF,Holst J,Grau G,Goel S,Muller T,Dejana E,McCaughan G,Smyth MJ,Ganss R,Vadas MA,Gamble JR

更新日期：2017-08-15 00:00:00

abstract：:Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent...

journal_title：Cancer research

authors： Hershberger PA,Vasquez AC,Kanterewicz B,Land S,Siegfried JM,Nichols M

更新日期：2005-02-15 00:00:00

abstract：:Local chemotherapy with biodegradable polymers prolongs survival with minimal morbidity in patients with intracranial high-grade gliomas. However, use of local chemotherapy for metastatic brain tumors has not been defined. We studied the safety and the efficacy of locally delivered chemotherapy with and without concur...

journal_title：Cancer research

authors： Ewend MG,Williams JA,Tabassi K,Tyler BM,Babel KM,Anderson RC,Pinn ML,Brat DJ,Brem H

更新日期：1996-11-15 00:00:00

abstract：:Electron spin resonance (ESR) studies at -130 degrees have been made on frozen samples of normal human cervix and uterus and on frozen samples of various pathological conditions of the cervix and uterus including fibroleiomyoma and carcinoma. Fifty-five samples of normal cervix and endometrium, 40 samples of nonmalign...

journal_title：Cancer research

authors： Benedetto C,Bocci A,Dianzani MU,Ghiringhello B,Slater TF,Tomasi A,Vannini V

更新日期：1981-07-01 00:00:00

abstract：:A monoclonal antibody prepared against the Rauscher virus envelope glycoprotein with a molecular weight of 70,000 targeted to neoplastic cells and cured the Rauscher leukemia virus-induced erythroleukemia in BALB/c mice. This antibody, 103A, specifically reacted with the Rauscher and Friend erythroleukemia viruses and...

journal_title：Cancer research

authors： Scheinberg DA,Strand M

更新日期：1982-01-01 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation after myelosuppressive chemotherapy is used for the treatment of high-risk breast cancer and other solid tumors. However, contamination of the autologous graft with tumor cells may adversely affect outcomes. Human hematopoietic bone marrow cells are resistant to herpe...

journal_title：Cancer research

authors： Wu A,Mazumder A,Martuza RL,Liu X,Thein M,Meehan KR,Rabkin SD

更新日期：2001-04-01 00:00:00

abstract：:Activation of activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB)-dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFkappaB activation by intera...

journal_title：Cancer research

authors： Matthews CP,Birkholz AM,Baker AR,Perella CM,Beck GR Jr,Young MR,Colburn NH

更新日期：2007-03-15 00:00:00

abstract：:To determine whether there are differences between the U1, U2, and U3 small nuclear RNA's of human cancer cells (HeLa cells) and human normal fibroblasts (IMR-90 cells), and between these uridine-rich small nuclear RNA's of human and Novikoff hepatoma cells, the cells were first incubated in Eagle's medium with [32P]P...

journal_title：Cancer research

authors： Nohga K,Reddy R,Busch H

更新日期：1981-06-01 00:00:00

abstract：:Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diver...

journal_title：Cancer research

authors： Lin DC,Mayakonda A,Dinh HQ,Huang P,Lin L,Liu X,Ding LW,Wang J,Berman BP,Song EW,Yin D,Koeffler HP

更新日期：2017-05-01 00:00:00

abstract：:We have shown previously that the pathways leading to Fas-mediated apoptosis in prostatic carcinoma cell lines are intact, because apoptosis can be triggered either by Fas ligation alone in the Fas-sensitive cell lines PC3 and ALVA31 or by rendering the Fas-resistant cell lines DU145 and JCA1 Fas-sensitive by combined...

journal_title：Cancer research

authors： Gewies A,Rokhlin OW,Cohen MB

更新日期：2000-04-15 00:00:00

abstract：:Inorganic pyrophosphatase (PPiase) activity was measured in cell fractions of rat, mouse, and human erythrocytes; normal rat liver; Novikoff hepatoma; Morris 3924A hepatoma; and mouse Ehrlich and Sarcoma 37 ascites tumors. Despite high intracellular activities, when precautions were taken to maintain cell integrity, o...

journal_title：Cancer research

authors： Shatton JB,Williams A,Weinhouse S

更新日期：1983-08-01 00:00:00

abstract：:Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced transformation. To establish a stable reporter cell system, two report...

journal_title：Cancer research

authors： Li JJ,Westergaard C,Ghosh P,Colburn NH

更新日期：1997-08-15 00:00:00

abstract：:The pattern of proliferation of epithelial cells in esophageal epithelium was studied by means of [3H]deoxythymidine labeling of esophageal epithelium in subjects from Huixian, Henan Province, China, a high-risk geographical region for esophageal cancer. Comparisons were made among patterns of cell proliferation obser...

journal_title：Cancer research

authors： Wang LD,Lipkin M,Qui SL,Yang GR,Yang CS,Newmark HL

更新日期：1990-05-01 00:00:00

abstract：:We studied the role of glycosphingolipids expressed on the cell surfaces of a metastatic tumor cell line. Glycosphingolipid compositions of the low-metastatic murine lymphosarcoma cell line RAW117-P and its sub-line, RAW117-H10, which shows higher metastatic potential for the liver than P cells, were compared. Both ty...

journal_title：Cancer research

authors： Taki T,Ishikawa D,Ogura M,Nakajima M,Handa S

更新日期：1997-05-15 00:00:00