Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:The in vitro antiproliferative effect of highly purified recombinant human gamma-interferon was studied with special reference to specific binding to tumor cells of interferon (IFN) labeled with 125I. Recombinant human gamma-interferon markedly suppressed the growth of 6 of 10 human epidermal tumor cell lines tested; ...

journal_title：Cancer research

authors： Nagao S,Sato K,Osada Y

更新日期：1986-07-01 00:00:00

abstract：:Maintenance of long term culture and conventional xenografting of early B-lineage acute lymphoblastic leukemia cells is most difficult. Matrigel, a solubilized attachment matrix shown to aid growth of anchorage dependent solid tumors, was studied in heterotransplantation. Material for xenografting was derived from 5 p...

journal_title：Cancer research

authors： Sterling-Levis K,White L,Trickett AE,Gramacho C,Pittman SM,Tobias V

更新日期：1993-03-15 00:00:00

abstract：:Patients suffering from bone metastases of follicular thyroid carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of epidermal growth factor receptor (EGFR) associated with increased vascularity has been implicated in the pathogenesis of FTC and subsequent bo...

journal_title：Cancer research

authors： Younes MN,Yigitbasi OG,Park YW,Kim SJ,Jasser SA,Hawthorne VS,Yazici YD,Mandal M,Bekele BN,Bucana CD,Fidler IJ,Myers JN

更新日期：2005-06-01 00:00:00

abstract：:Nile blue derivatives have been shown to be potentially effective photosensitizers for photodynamic therapy of malignant tumors. Results of a previous study suggested that the high accumulation of these dyes in cells may be the result of dye aggregation, partition in membrane lipids, and/or sequestration in subcellula...

journal_title：Cancer research

authors： Lin CW,Shulok JR,Kirley SD,Cincotta L,Foley JW

更新日期：1991-05-15 00:00:00

abstract：:Regulation of c-myc expression is known to be sensitive to a variety of mitogenic stimuli in various cell types. Since estrogen is a well documented mitogen of estrogen-responsive human breast cancer (HBC) cells, we studied the influence of estradiol and its antagonist tamoxifen on the expression of c-myc in HBC cell ...

journal_title：Cancer research

authors： Dubik D,Dembinski TC,Shiu RP

更新日期：1987-12-15 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascer...

journal_title：Cancer research

authors： Santiago C,Pagán B,Isidro AA,Appleyard CB

更新日期：2007-11-15 00:00:00

abstract：:Interleukin 2 (IL-2) is a secreted glycoprotein which acts as an activation and proliferative signal for lymphocytes expressing membrane-bound glycoprotein IL-2 receptors. We have recently established that swainsonine (SW), an inhibitor of mannosidase II during N-linked glycoprotein processing, augmented mitogen-induc...

journal_title：Cancer research

authors： Bowlin TL,McKown BJ,Kang MS,Sunkara PS

更新日期：1989-08-01 00:00:00

abstract：:Cell culture studies have been performed to compare the mutagenic potential and the induction of sister chromatid exchanges for hematoporphyrin derivative photoradiation, ionizing radiation, and UV radiation. The mutation frequency in Chinese hamster ovary cells at the hypoxanthine-guanine phosphoribosyltransferase lo...

journal_title：Cancer research

authors： Gomer CJ,Rucker N,Banerjee A,Benedict WF

更新日期：1983-06-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the prognostic of this deadly disease. The present study was undertaken to investigate the action of cannabinoids, a new family of potential antitumoral agents, in...

journal_title：Cancer research

authors： Carracedo A,Gironella M,Lorente M,Garcia S,Guzmán M,Velasco G,Iovanna JL

更新日期：2006-07-01 00:00:00

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response t...

journal_title：Cancer research

authors： Holinka CF,Deligdisch L,Gurpide E

更新日期：1984-01-01 00:00:00

abstract：:The biological effects of antioxidants are often considered in terms of their effects on oxygen or lipid radicals. However, antioxidants can also exert their effects through altering the cellular redox potential. Herein, we report that sulfur-containing antioxidants such as N-acetylcysteine and dimercaptopropanol indu...

journal_title：Cancer research

authors： Liu M,Pelling JC,Ju J,Chu E,Brash DE

更新日期：1998-04-15 00:00:00

abstract：:The use of targeted therapeutics directed against BRAF(V600)-mutant metastatic melanoma improves progression-free survival in many patients; however, acquired drug resistance remains a major medical challenge. By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK) pathway...

journal_title：Cancer research

authors： Goetz EM,Ghandi M,Treacy DJ,Wagle N,Garraway LA

更新日期：2014-12-01 00:00:00

abstract：:We developed a novel orthotopic mouse tumor model of renal cell carcinoma to collect and characterize cells spontaneously shed from SN12C (renal cell carcinoma) and SN12L1 (high metastatic variant of SN12C) tumors grown in kidneys of severe combined immunodeficient mice. Viability of the shed cell population was great...

journal_title：Cancer research

authors： Bockhorn M,Roberge S,Sousa C,Jain RK,Munn LL

更新日期：2004-04-01 00:00:00

abstract：:N-Hydroxyarylamides are metabolically activated to nucleic acid-binding species by the action of N,O-acyltransferase (AT). The substrate specificity of these enzymes in rat, guinea pig, monkey, baboon, pig, and human liver has been examined by measuring the AT-mediated nucleic acid binding of the N-formyl, N-acetyl, a...

journal_title：Cancer research

authors： Beland FA,Allaben WT,Evans FE

更新日期：1980-03-01 00:00:00

abstract：:Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide m...

journal_title：Cancer research

authors： Gold A,Nesnow S,Moore M,Garland H,Curtis G,Howard B,Graham D,Eisenstadt E

更新日期：1980-12-01 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:Breast cancer stem-like cells (BCSC) have been implicated in tumor growth, metastasis, drug resistance, and relapse but druggable targets in appropriate subsets of this cell population have yet to be identified. Here we identify a fundamental role for the prolyl isomerase Pin1 in driving BCSC expansion, invasiveness, ...

journal_title：Cancer research

authors： Luo ML,Gong C,Chen CH,Lee DY,Hu H,Huang P,Yao Y,Guo W,Reinhardt F,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

更新日期：2014-07-01 00:00:00

abstract：:We previously reported that both sodium butyrate and trichostatin A (TSA), both of which are known as inhibitors of histone deacetylase, arrest human tumor cells at G1 and G2-M and activate the cyclin-dependent kinase inhibitor, the p21/WAF1/Cip1 gene promoter, through the Sp1 sites. In this study, we identified Sp1 a...

journal_title：Cancer research

authors： Sowa Y,Orita T,Minamikawa-Hiranabe S,Mizuno T,Nomura H,Sakai T

更新日期：1999-09-01 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:We have investigated the ability of several drugs commonly used in the treatment of human cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute leukemia, lymphoma, breast cancer, and prostate cancer. The results of this analysis indicate that drugs affecting the integrity of micro...

journal_title：Cancer research

authors： Haldar S,Basu A,Croce CM

更新日期：1997-01-15 00:00:00

abstract：:Hypoxia initiates numerous intracellular signaling pathways important in regulating cell proliferation, differentiation, and death. In this study, we investigated the pathway that hypoxia uses to activate Akt and inactivate glycogen synthase kinase-3 (GSK-3), two proteins the functions of which are important in cell s...

journal_title：Cancer research

authors： Chen EY,Mazure NM,Cooper JA,Giaccia AJ

更新日期：2001-03-15 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental stress produces ep...

journal_title：Cancer research

authors： Koss B,Shields BD,Taylor EM,Storey AJ,Byrum SD,Gies AJ,Washam CL,Choudhury SR,Hyun Ahn J,Uryu H,Williams JB,Krager KJ,Chiang TC,Mackintosh SG,Edmondson RD,Aykin-Burns N,Gajewski TF,Wang GG,Tackett AJ

更新日期：2020-11-01 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:In vitro systems that are responsive to tumor-promoting agents may facilitate the identification of such agents and the analysis of their mode of action. We have previously reported that the potent tumor promoter phorbol-12-myristate-13-acetate induces the synthesis of the enzyme plasminogen activator in cultured chic...

journal_title：Cancer research

authors： Wigler M,DeFeo D,Weinstein IB

更新日期：1978-05-01 00:00:00