Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.

abstract：:The majority of colorectal cancers have lost/inactivated the p53 tumor suppressor gene. Using isogenic human colon cancer cells that differ only in their p53 status, we demonstrate that loss of p53 renders tumor cells relatively resistant to the topoisomerase I inhibitor, irinotecan. Whereas irinotecan-induced up-regu...

journal_title：Cancer research

authors： Ravi R,Jain AJ,Schulick RD,Pham V,Prouser TS,Allen H,Mayer EG,Yu H,Pardoll DM,Ashkenazi A,Bedi A

更新日期：2004-12-15 00:00:00

abstract：:The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like cells have been assumed to have unique properties, including the capability of se...

journal_title：Cancer research

authors： Tamiro F,Weng AP,Giambra V

更新日期：2021-01-07 00:00:00

abstract：:The Salmonella-microsome assay for mutagenesis was used to determine the effect of ozone on the mutagenesis of selected carcinogens and mutagens in water. Short periods of ozonation were shown to completely inactivate the mutagenicity of several polyaromatic amine mutagens including acriflavine, proflavine, and beta-n...

journal_title：Cancer research

authors： Burleson GR,Caulfield MJ,Pollard M

更新日期：1979-06-01 00:00:00

abstract：:Donor lymphocyte infusions (DLI) provide effective therapy for patients with multiple myeloma who have relapsed after allogeneic bone marrow transplantation. However, the immunological mechanisms of the graft-versus-myeloma (GVM) effect have not been defined, and the target antigens of this response have not been iden...

journal_title：Cancer research

authors： Orsini E,Bellucci R,Alyea EP,Schlossman R,Canning C,McLaughlin S,Ghia P,Anderson KC,Ritz J

更新日期：2003-05-15 00:00:00

abstract：:Topical 5-aminolevulinic acid-based photodynamic therapy (PDT) has produced complete response rates of >90% for nonmelanoma skin carcinomas, which are mostly human papillomavirus (HPV) negative. Using a similar treatment protocol, we observed a short-term response in only one third (10 of 32) of high-grade vulval intr...

journal_title：Cancer research

authors： Abdel-Hady ES,Martin-Hirsch P,Duggan-Keen M,Stern PL,Moore JV,Corbitt G,Kitchener HC,Hampson IN

更新日期：2001-01-01 00:00:00

abstract：:Leukemia following chemotherapy for breast cancer was studied among patients diagnosed during 1973-1985 within the population-based tumor registries in the Surveillance, Epidemiology, and End Results Program. Among 13,734 women given initial chemotherapy, 24 developed acute nonlymphocytic leukemia (ANLL) compared to 2...

journal_title：Cancer research

authors： Curtis RE,Boice JD Jr,Moloney WC,Ries LG,Flannery JT

更新日期：1990-05-01 00:00:00

abstract：:Structural analysis of the sugar chains of human chorionic gonadotropin (hCG) has revealed that abnormal biantennary structures appear specifically on hCG in the urine of choriocarcinoma patients. However, the enzymatic and molecular mechanisms of the biosynthesis of abnormal biantennary sugar chains have not yet been...

journal_title：Cancer research

authors： Takamatsu S,Oguri S,Minowa MT,Yoshida A,Nakamura K,Takeuchi M,Kobata A

更新日期：1999-08-15 00:00:00

abstract：:The effect of caerulein on the incidence and histology of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine was investigated in inbred Wistar rats. Prolonged alternate-day administration of caerulein at 10 micrograms/kg body weight after treatment with the carcinogen for 20 weeks significantly in...

journal_title：Cancer research

authors： Tatsuta M,Iishi H,Baba M,Yamamura H,Taniguchi H

更新日期：1988-11-15 00:00:00

abstract：:Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or 2'-f...

journal_title：Cancer research

authors： Tang B,Lee HO,An SS,Cai KQ,Kruger WD

更新日期：2018-08-01 00:00:00

abstract：:In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then esta...

journal_title：Cancer research

authors： Man J,Pajic M,Joshua AM

更新日期：2020-11-15 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this ...

journal_title：Cancer research

authors： Lee HS,Lee NC,Kouprina N,Kim JH,Kagansky A,Bates S,Trepel JB,Pommier Y,Sackett D,Larionov V

更新日期：2016-02-15 00:00:00

abstract：:The presence of a non-small cell lung carcinoma (NSCLC)-related gene or genes on chromosome band 11p15.5 is of particular interest, given the specific loss of heterozygosity (LOH) measured in this region for lung as well as many other pediatric and adult neoplasms. We have undertaken high-density polymorphic marker an...

journal_title：Cancer research

authors： Tran YK,Newsham IF

更新日期：1996-07-01 00:00:00

abstract：:The effects of combined administration of cimetidine and tetragastrin on gastric acid secretion, the labeling index of the gastric mucosa, and the incidence of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine were investigated in inbred Wistar rats. Prolonged administration of tetragastrin in de...

journal_title：Cancer research

authors： Tatsuta M,Iishi H,Yamamura H,Baba M,Yamamoto R,Taniguchi H

更新日期：1988-03-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors are undergoing clinical evaluation for cancer therapy. Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we have investigated the effects of the HDAC inhibitor MS-275 on the radiosensitivity of two human tumor cell li...

journal_title：Cancer research

authors： Camphausen K,Burgan W,Cerra M,Oswald KA,Trepel JB,Lee MJ,Tofilon PJ

更新日期：2004-01-01 00:00:00

abstract：:Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

journal_title：Cancer research

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1990-05-15 00:00:00

abstract：:Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood but only a few cell lines and animal models of this primitive neuroectodermal tumor (PNET) have thus far been established. Using specific cell culture conditions, we were able to derive four human MB cell lines (MHH-MED-1-4) as well a...

journal_title：Cancer research

authors： Pietsch T,Scharmann T,Fonatsch C,Schmidt D,Ockler R,Freihoff D,Albrecht S,Wiestler OD,Zeltzer P,Riehm H

更新日期：1994-06-15 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a common soft-tissue sarcoma of childhood in need of more effective therapeutic options. The expression of p53 in RMS is heterogeneous such that some tumors are wild-type whereas others are p53 mutant. The small molecule CP-31398 modulates both the wild-type and the mutant p53 proteins. Here,...

journal_title：Cancer research

authors： Xu J,Timares L,Heilpern C,Weng Z,Li C,Xu H,Pressey JG,Elmets CA,Kopelovich L,Athar M

更新日期：2010-08-15 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:We have recently reported a simple and reproducible technique for the purification and rapid expansion of homogeneous populations of large granular lymphocytes expressing a natural killer cell phenotype and high levels of broad antitumor cytotoxic activity [lymphokine-activated killer (LAK) activity]. This technique e...

journal_title：Cancer research

authors： Schwarz RE,Vujanovic NL,Hiserodt JC

更新日期：1989-03-15 00:00:00

abstract：:To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis, 7 CpG islands [methylated in carcinoma of the pancreas (MICP)] w...

journal_title：Cancer research

authors： Ueki T,Toyota M,Skinner H,Walter KM,Yeo CJ,Issa JP,Hruban RH,Goggins M

更新日期：2001-12-01 00:00:00

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:Recently, we developed a nutritionally optimal medium for rapid clonal growth (greater than 1 population doubling/day) of normal human bronchial epithelial (NHBE) cells. Adding fetal bovine or adult human blood-derived serum to this medium depresses the clonal growth rate of NHBE cells in a dose-dependent fashion. In ...

journal_title：Cancer research

authors： Lechner JF,McClendon IA,LaVeck MA,Shamsuddin AM,Harris CC

更新日期：1983-12-01 00:00:00

abstract：:Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationw...

journal_title：Cancer research

authors： Akre K,Signorello LB,Engstrand L,Bergström R,Larsson S,Eriksson BI,Nyrén O

更新日期：2000-11-15 00:00:00

abstract：:We examined in vivo DNA repair synthesis in liver and lung of A/HeJ mice treated with benzo(a)pyrene (BP) or 4-nitroquinoline 1-oxide. To differentiate between the removal of carcinogen metabolite:DNA adducts due to cell turnover and DNA repair, we measured unscheduled DNA synthesis (UDS) in the nonreplicating DNA fra...

journal_title：Cancer research

authors： Kulkarni MS,Angerman-Stewart J,Anderson MW

更新日期：1984-04-01 00:00:00

abstract：:Using the principle of functional polarization of dendritic cells (DCs), we have developed a novel protocol to generate human DCs combining the three features critical for the induction of type-1 immunity: (a) fully mature status; (b) responsiveness to secondary lymphoid organ chemokines; and (c) high interleukin-12p7...

journal_title：Cancer research

authors： Mailliard RB,Wankowicz-Kalinska A,Cai Q,Wesa A,Hilkens CM,Kapsenberg ML,Kirkwood JM,Storkus WJ,Kalinski P

更新日期：2004-09-01 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00