Ozonation of mutagenic and carcinogenic polyaromatic amines and polyaromatic hydrocarbons in water.

Abstract:

:The Salmonella-microsome assay for mutagenesis was used to determine the effect of ozone on the mutagenesis of selected carcinogens and mutagens in water. Short periods of ozonation were shown to completely inactivate the mutagenicity of several polyaromatic amine mutagens including acriflavine, proflavine, and beta-naphthylamine. Selected polyaromatic hydrocarbons were also sensitive to ozonation. Kinetic studies revealed that the mutagenicity of benzo(a)pyrene, 3-methylcholanthrene, and 7,12-dimethylbenz(a)anthracene was destroyed after short periods of ozonation. To correlate loss of mutagenicity with loss of carcinogenicity, two polyaromatic hydrocarbons were treated with ozone, extracted from water with hexane, and tested for carcinogenicity in mice. When 7,12-dimethyl-benz(a)anthracene and 3-methyl-cholanthrene were treated with ozone, there was a substantial reduction in carcinogenicity compared to control groups treated with oxygen alone. However, a small number of tumors developed in the group of animals receiving a hexane extract of ozonated 7,12-dimethylbenz(a)anthracene. This activity may be due to breakdown products of 7,12-dimethylbenz(a)anthracene that are not mutagenic.

journal_name

Cancer Res

journal_title

Cancer research

authors

Burleson GR,Caulfield MJ,Pollard M

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

2149-54

issue

6 Pt 1

eissn

0008-5472

issn

1538-7445

journal_volume

39

pub_type

杂志文章
  • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

    abstract::The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.can-03-2522

    authors: Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

    更新日期:2004-01-01 00:00:00

  • Androgen dependency of a tumor produced by a cell line derived from androgen-responsive Shionogi carcinoma 115.

    abstract::An androgen-dependent tumor (SCC8 tumor) was obtained by inoculating an androgen-responsive cell line derived from the androgen-responsive Shionogi carcinoma 115 (SC115) into mice and then treating the mice with testosterone propionate (TP) at a pharmacological dose (400 micrograms/day). The SCC8 tumor differed in his...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Terada N,Yamamoto R,Uchida N,Takada T,Taniguchi H,Takatsuka D,Sawada M,Tsuji M,Li W,Kitamura Y

    更新日期:1989-02-01 00:00:00

  • Dose-related reduction by prenatal x-irradiation of the transplacental neurocarcinogenicity of ethylnitrosourea in rats.

    abstract::Pregnant Sprague-Dawley rats were X-irradiated on the 16th day of gestation with 5 to 250 rads and given i.p. injections 4 days later with 10 mg ethylnitrosourea per kg. The offspring were observed over their life span for the appearance of neurogenic tumors. The frequency of animals surviving beyond 4 weeks of age th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kalter H,Mandybur TI,Ormsby I,Warkany J

    更新日期:1980-11-01 00:00:00

  • Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase.

    abstract::Immunologic targeting of the oncoprotein HER2/neu with monoclonal antibodies is an important component of current therapeutic strategies for patients with locally and systemically advanced breast cancer. Engineered antibodies targeting HER2 may have agonist or antagonist effects on HER2, but little is known about whet...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Montgomery RB,Makary E,Schiffman K,Goodell V,Disis ML

    更新日期:2005-01-15 00:00:00

  • Effects of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats.

    abstract::To determine whether the kind of dietary fat affects colon carcinogenesis, male Donryu rats were fed a 5% fat diet containing linoleate, an unsaturated fat, or stearate, a saturated fat, in semipurified fat-free chow. The rats were given azoxymethane (7.4 mg/kg body weight) s.c. once a week for 11 weeks and killed 15 ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sakaguchi M,Minoura T,Hiramatsu Y,Takada H,Yamamura M,Hioki K,Yamamoto M

    更新日期:1986-01-01 00:00:00

  • The CpG island methylator phenotype is not associated with a personal or family history of cancer.

    abstract::Colorectal cancers with widespread CpG island methylation display a number of distinct clinicopathological features, and it has been suggested that the condition has an inheritable genetic component. To address this possibility, histories of cancer were obtained from 562 individuals undergoing curative surgery for uns...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-03-3978

    authors: Ward RL,Williams R,Law M,Hawkins NJ

    更新日期:2004-10-15 00:00:00

  • Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment.

    abstract::The clinical management of cutaneous melanoma would benefit significantly from a better understanding of the molecular changes that occur during melanocytic progression to a melanoma phenotype. To gain unique insights into this process, we developed a three-dimensional in vitro model that allows observations of normal...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-2497

    authors: Seftor EA,Brown KM,Chin L,Kirschmann DA,Wheaton WW,Protopopov A,Feng B,Balagurunathan Y,Trent JM,Nickoloff BJ,Seftor RE,Hendrix MJ

    更新日期:2005-11-15 00:00:00

  • Selective localization of matrix metalloproteinase 9, beta1 integrins, and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast carcinoma cells.

    abstract::The shedding of membrane vesicles from the cell surface is a vital process considered to be involved in cell-cell and cell-matrix interactions and in tumor progression. By immunoelectron microscopic analysis of surface replicas of 8701-BC human breast carcinoma cells, we observed that membrane vesicles shed from plasm...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dolo V,Ginestra A,Cassarà D,Violini S,Lucania G,Torrisi MR,Nagase H,Canevari S,Pavan A,Vittorelli ML

    更新日期:1998-10-01 00:00:00

  • Microvessel origin and distribution in pulmonary metastases of B16 melanoma: implication for adoptive immunotherapy.

    abstract::To elucidate the role of tumor vascularization on the localization of adoptively transferred, interleukin 2-activated natural killer (A-NK) cells, pulmonary B16 melanoma metastases were analyzed with respect to location, morphological appearance, origin and density of microvessels, and infiltration by A-NK cells. The ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nannmark U,Johansson BR,Bryant JL,Unger ML,Hokland ME,Goldfarb RH,Basse PH

    更新日期:1995-10-15 00:00:00

  • Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor.

    abstract::3,4-Dihydro-2,2-dimethyl-2H-naptho[1,2,-b]pyran-5,6-dione (beta-lapachone) is a novel DNA repair inhibitor. It was tested for synergistic X-ray-induced lethality in combination with several halogenated pyrimidine radiosensitizers. Logarithmic-phase growing human epidermoid laryngeal carcinoma (HEp-2) cells were allowe...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Boothman DA,Greer S,Pardee AB

    更新日期:1987-10-15 00:00:00

  • Solubilization and developmental distribution of embryonic antigen of the chick red blood cell plasma membrane.

    abstract::An antigen(s) on the surface of embryonic and newly hatched chick red blood cells was studied with antiserum absorbed with adult red blood cells. Because of the reappearance of the antigen or some cross-reactive antigen during myeloblastosis, attempts at solubilization and characterization of the antigen were pursued....

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: O'Brien TJ,Teplitz RL

    更新日期:1978-04-01 00:00:00

  • Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.

    abstract::[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4- butane-diamine-N,N')platinum (CI-973) is a cisplatin analogue that is currently in clinical trial. Preclinically, CI-973 retained activity against L1210, P388, K562, and human ovarian carcinoma sublines resistant to cisplatin in vitro. CI-973 also retained ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Elliott WL,Roberts BJ,Howard CT,Leopold WR 3rd

    更新日期:1994-08-15 00:00:00

  • Quantitative prediction of drug toxicity in humans from toxicology in small and large animals.

    abstract::The mouse, dog, and monkey toxicity data on 30 drugs was retrospectively analyzed in comparison with the actual clinical dose schedules used in man. Animal dose schedules were converted to the human schedule and comparisons were made of the human dose versus the large animal toxic dose low, toxic dose high, and lethal...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Goldsmith MA,Slavik M,Carter SK

    更新日期:1975-05-01 00:00:00

  • 67Ga-labeled antibodies for immunoscintigraphy and evaluation of tumor targeting of drug-antibody conjugates in mice.

    abstract::To assess the in vivo behavior of cytotoxic agents linked to antibodies, deferoxamine, known to form stable chelates with 67Ga, was conjugated with monoclonal antibodies using three different methods. One method used a homocoupling reagent, glutaraldehyde, whereas two other methods used heterocoupling reagents, N-succ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Koizumi M,Endo K,Kunimatsu M,Sakahara H,Nakashima T,Kawamura Y,Watanabe Y,Saga T,Konishi J,Yamamuro T

    更新日期:1988-03-01 00:00:00

  • Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.

    abstract::The MRP (multidrug resistance protein) gene, a member of the ubiquitous superfamily of ATP-binding cassette transporters, is associated with the multidrug resistance of mammalian cells to natural product anticancer agents. We have previously shown that abrogation of MRP expression by gene targeting leads to hypersensi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rappa G,Lorico A,Flavell RA,Sartorelli AC

    更新日期:1997-12-01 00:00:00

  • Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

    abstract::This paper describes the laboratory discovery and clinical testing of the first nonsteroidal antiestrogen, MER-25 (ethamoxytriphetol). The compound blocks estrogen action in all species tested and has only slight but transient estrogenic effects. No other antisteroidal actions are noted. MER-25 is antiestrogenic in pr...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Lerner LJ,Jordan VC

    更新日期:1990-07-15 00:00:00

  • A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

    abstract::Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-2841

    authors: Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

    更新日期:2016-07-01 00:00:00

  • In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

    abstract::Aberrant signal transduction has been implicated in malignant transformation, growth, and progression. This has led to the proposal to use inhibitors of signal transduction pathways to treat cancer. One approach to circumventing potential toxicity and improving efficacy would be to target pathways upon which cancer ce...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kohn EC,Sandeen MA,Liotta LA

    更新日期:1992-06-01 00:00:00

  • Cell surface changes in HeLa cells as an indication of cell cycle events.

    abstract::A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Lundgren E,Roos G

    更新日期:1976-11-01 00:00:00

  • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

    abstract::In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as correlations between the integrity of this pathway and the growth-inhibitory potency of 123 anticancer agents in this screen. Assessmen...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: O'Connor PM,Jackman J,Bae I,Myers TG,Fan S,Mutoh M,Scudiero DA,Monks A,Sausville EA,Weinstein JN,Friend S,Fornace AJ Jr,Kohn KW

    更新日期:1997-10-01 00:00:00

  • Ras oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosine.

    abstract::Human tumor cells containing ras oncogenes display enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine (Ara-C) and other deoxycytidine analogues (H-M. Koo, et al., Cancer Res., 56: 5211-5216, 1996). Human tumor cell lines with or without a ras oncogene as well as a pair of isogenic cell lines with one containing...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Koo HM,McWilliams MJ,Alvord WG,Vande Woude GF

    更新日期:1999-12-15 00:00:00

  • High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors.

    abstract::Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targeted mass spectrometry-based methods used to monitor pTyr networks invol...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-3804

    authors: Stopfer LE,Flower CT,Gajadhar AS,Patel B,Gallien S,Lopez-Ferrer D,White FM

    更新日期:2021-01-28 00:00:00

  • Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer.

    abstract::The ErbB2 receptor tyrosine kinase is overexpressed in approximately 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer. We observe that LRIG1 protein levels are signific...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-6316

    authors: Miller JK,Shattuck DL,Ingalla EQ,Yen L,Borowsky AD,Young LJ,Cardiff RD,Carraway KL 3rd,Sweeney C

    更新日期:2008-10-15 00:00:00

  • A randomized trial of dietary intervention for breast cancer prevention.

    abstract::Epidemiologic data and animal experiments suggest that dietary fat may influence risk of breast cancer. To determine whether intervention with a low-fat, high-carbohydrate diet would reduce breast cancer incidence in women at increased risk of the disease, we carried out a randomized controlled trial in Canada. We rec...

    journal_title:Cancer research

    pub_type: 杂志文章,随机对照试验

    doi:10.1158/0008-5472.CAN-10-1436

    authors: Martin LJ,Li Q,Melnichouk O,Greenberg C,Minkin S,Hislop G,Boyd NF

    更新日期:2011-01-01 00:00:00

  • Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.

    abstract::SPARC is an extracellular matrix protein that exerts pleiotropic effects on extracellular matrix organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer. Chronic myelogenous leukemia (CML) cells resistant to the BCR-ABL inhibitor imatinib (IM-R cells) were found to overexpress ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-2034

    authors: Fenouille N,Puissant A,Dufies M,Robert G,Jacquel A,Ohanna M,Deckert M,Pasquet JM,Mahon FX,Cassuto JP,Raynaud S,Tartare-Deckert S,Auberger P

    更新日期:2010-12-01 00:00:00

  • Antagonist of phorbol ester receptor-mediated chemotaxis in mouse peritoneal macrophages.

    abstract::Biologically active phorbol ester derivatives displace [3H]phorbol-12, 13-dibutyrate from thioglycollate-elicited mouse peritoneal macrophages in a time-, temperature-, and concentration-dependent manner. Scatchard analysis revealed an apparent Kd of 54.1 nM and 8.0 X 10(5) sites/cell, indicating that these macrophage...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sturm RJ,Smith BM,Lane RW,Laskin DL,Harris LS,Carchman RA

    更新日期:1983-10-01 00:00:00

  • Structure and expression of the c-sis gene and its relationship to sporadic meningiomas.

    abstract::A deletion in an Alu repetitive sequence in the fifth intron of the c-sis gene of meningioma patients was previously described (M. Smidt et al., J. Clin. Invest., 86:1151-1157, 1990). The authors analyzed the structure of this intron in DNA from peripheral blood leukocytes and tumor samples of 86 patients with sporadi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Smidt M,Dumanski JP,Collins VP,Ratner L

    更新日期:1991-08-15 00:00:00

  • Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.

    abstract::Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumo...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-3060

    authors: Yeo CW,Ng FS,Chai C,Tan JM,Koh GR,Chong YK,Koh LW,Foong CS,Sandanaraj E,Holbrook JD,Ang BT,Takahashi R,Tang C,Lim KL

    更新日期:2012-05-15 00:00:00

  • The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.

    abstract::The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of gene...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-2487

    authors: Maussang D,Langemeijer E,Fitzsimons CP,Stigter-van Walsum M,Dijkman R,Borg MK,Slinger E,Schreiber A,Michel D,Tensen CP,van Dongen GA,Leurs R,Smit MJ

    更新日期:2009-04-01 00:00:00

  • Ascorbic acid and cancer: a review.

    abstract::Host resistance to neoplastic growth and invasiveness is recognized to be an important factor in determining the occurrence, the progress, and the eventual outcome of every cancer illness. The factors involved in host resistance are briefly reviewed, and the relationship between these factors and ascorbic acid metabol...

    journal_title:Cancer research

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Cameron E,Pauling L,Leibovitz B

    更新日期:1979-03-01 00:00:00