Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer.

abstract：:Histone deacetylase (HDAC) inhibitors are known to exert antimetastatic and antiangiogenic activity in vitro and in vivo. RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. In this study, we test the possibility that HDAC ...

journal_title：Cancer research

authors： Liu LT,Chang HC,Chiang LC,Hung WC

更新日期：2003-06-15 00:00:00

abstract：:Bropirimine (ABPP), a pyrimidinone, is currently under clinical trial for its antitumor potential. Bropirimine alone was marginally active against some experimental tumors such as B16 melanoma but was ineffective against others such as P388 or L1210 leukemia. However, it produced statistically significant synergistic ...

journal_title：Cancer research

authors： Li LH,DeKoning TF,Wallace TL

更新日期：1987-11-15 00:00:00

abstract：:Prostate cancer (PCa) is the most common male cancer in the United States. A major challenge that remains is to predict the clinical outcome in managing PCa patients. The prolyl isomerase Pin1 has been shown to be overexpressed in some human cancer tissues and thought to be an important player in several oncogenic pat...

journal_title：Cancer research

authors： Ayala G,Wang D,Wulf G,Frolov A,Li R,Sowadski J,Wheeler TM,Lu KP,Bao L

更新日期：2003-10-01 00:00:00

abstract：:The intranuclear mitosis of the plasmodial nuclei of myxomycetes permits the observation of defects in chromosomal repartition which would probably be lethal in other eukaryotic cells with open mitosis. We found that antitumoral platinum-amine compounds perturbed late mitotic events and induced the formation of giant ...

journal_title：Cancer research

authors： Wright M,Lacorre-Arescaldino I,Macquet JP,Daffé M

更新日期：1984-02-01 00:00:00

abstract：:The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals followi...

journal_title：Cancer research

authors： Duckworth-Rysiecki G,Taylor AM

更新日期：1985-01-01 00:00:00

abstract：:Aflatoxicol, R0, was isolated from Mt. Shasta strain rainbow trout (Salmo gairdneri), and liver homogenates were incubated with aflatoxin B1. Its identity was confirmed by mass, infrared, and ultraviolet spectrometry. The structure was identical to one of the diastereomers prepared by chemical reduction of aflatoxin B...

journal_title：Cancer research

authors： Schoenhard GL,Lee DJ,Howell SE,Pawlowski NE,Libbey LM,Sinnhuber RO

更新日期：1976-06-01 00:00:00

abstract：:An androgen-dependent tumor (SCC8 tumor) was obtained by inoculating an androgen-responsive cell line derived from the androgen-responsive Shionogi carcinoma 115 (SC115) into mice and then treating the mice with testosterone propionate (TP) at a pharmacological dose (400 micrograms/day). The SCC8 tumor differed in his...

journal_title：Cancer research

authors： Terada N,Yamamoto R,Uchida N,Takada T,Taniguchi H,Takatsuka D,Sawada M,Tsuji M,Li W,Kitamura Y

更新日期：1989-02-01 00:00:00

abstract：:Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene. In this report, we explored the molecular basis for p53-mediated down-regulation of bcl-2 gene expression using a cotransfection approach involving p53 expression plasmids and chloramphenicol acetyltransferase ...

journal_title：Cancer research

authors： Miyashita T,Harigai M,Hanada M,Reed JC

更新日期：1994-06-15 00:00:00

abstract：:Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignan...

journal_title：Cancer research

authors： Fava G,Alpini G,Rychlicki C,Saccomanno S,DeMorrow S,Trozzi L,Candelaresi C,Venter J,Di Sario A,Marzioni M,Bearzi I,Glaser S,Alvaro D,Marucci L,Francis H,Svegliati-Baroni G,Benedetti A

更新日期：2008-08-15 00:00:00

abstract：:Phorbol ester tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) alter the morphology and differentiated states of numerous cell types in vitro. It is likely that these molecules are teratogenic for vertebrate embryos in which cytodifferentiation, cell-tissue interactions, and cellular motility are pro...

journal_title：Cancer research

authors： Ellinger MS

更新日期：1982-07-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 through somatic mutations, observed in 50% of human cancers, is one of the leading causes of tumorigenesis. Clinical and experimental evidence also reveals that p53 mutations sometimes occur in tumor-associated fibroblasts, which correlate with an increased rate of metastases a...

journal_title：Cancer research

authors： Guo G,Marrero L,Rodriguez P,Del Valle L,Ochoa A,Cui Y

更新日期：2013-03-15 00:00:00

abstract：:Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity....

journal_title：Cancer research

authors： Dai J,Kitagawa Y,Zhang J,Yao Z,Mizokami A,Cheng S,Nör J,McCauley LK,Taichman RS,Keller ET

更新日期：2004-02-01 00:00:00

abstract：:We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We have compared instability measured by this method with that measured by inter-(simple sequence repeat) PCR...

journal_title：Cancer research

authors： Anderson GR,Brenner BM,Swede H,Chen N,Henry WM,Conroy JM,Karpenko MJ,Issa JP,Bartos JD,Brunelle JK,Jahreis GP,Kahlenberg MS,Basik M,Sait S,Rodriguez-Bigas MA,Nowak NJ,Petrelli NJ,Shows TB,Stoler DL

更新日期：2001-11-15 00:00:00

abstract：:We have investigated the behavior of dissociated cells of a moderately differentiated Longnecker transplantable pancreatic acinar carcinoma (Longnecker et al., Cancer Lett., 7: 197-202, 1979) maintained in vitro on acellular seminiferous tubular basement membranes of rat testis. The tumor cells, which grow as solid ma...

journal_title：Cancer research

authors： Reddy JK,Kanwar YS,Rao MS,Watanabe TK,Reddy MK,Parsa I,Longnecker DS,Tafuri S

更新日期：1986-01-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. V...

journal_title：Cancer research

authors： Platica M,Bojko C,Steiner G,Hollander VP

更新日期：1980-07-01 00:00:00

abstract：:The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have fo...

journal_title：Cancer research

authors： Giurisato E,Lonardi S,Telfer B,Lussoso S,Risa-Ebrí B,Zhang J,Russo I,Wang J,Santucci A,Finegan KG,Gray NS,Vermi W,Tournier C

更新日期：2020-08-15 00:00:00

abstract：:Normal human cells can be transformed to anchorage-independent growth by transfection with DNA from MOLT-4 lymphoblasts, derived from a patient with acute lymphocytic leukemia. Cells were treated with polyethylene glycol 6000, and DNA was administered as a calcium phosphate coprecipitate . The transforming activity of...

journal_title：Cancer research

authors： Sutherland BM,Bennett PV

更新日期：1984-07-01 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation after myelosuppressive chemotherapy is used for the treatment of high-risk breast cancer and other solid tumors. However, contamination of the autologous graft with tumor cells may adversely affect outcomes. Human hematopoietic bone marrow cells are resistant to herpe...

journal_title：Cancer research

authors： Wu A,Mazumder A,Martuza RL,Liu X,Thein M,Meehan KR,Rabkin SD

更新日期：2001-04-01 00:00:00

abstract：:In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine. Anti-idiotype 3H1 mimics a distinct and speci...

journal_title：Cancer research

authors： Saha A,Chatterjee SK,Foon KA,Primus FJ,Bhattacharya-Chatterjee M

更新日期：2003-06-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:The study of DNA tumor viruses has been invaluable in uncovering the cellular nodes and pathways that contribute to oncogenesis. Perhaps one of the best-studied oncoproteins encoded by a DNA tumor virus is adenovirus E1A, which modifies the function of key regulatory proteins such as retinoblastoma (Rb) and the chroma...

journal_title：Cancer research

authors： Chakraborty AA,Tansey WP

更新日期：2009-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors are approved for treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a very long-acting PARP inhibitor. Synthesis of a macromolecular prodrug of talazoparib (TLZ) was achieved by covalent conjugation to a PEG40kDa carrier via a β-...

journal_title：Cancer research

authors： Fontaine SD,Ashley GW,Houghton PJ,Kurmasheva RT,Diolaiti M,Ashworth A,Peer CJ,Nguyen R,Figg WD,Beckford-Vera DR,Santi DV

更新日期：2020-12-15 00:00:00

abstract：:Dicer1 functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults, and patients with DICER1 syndrome with DICER1 germline mutations are susceptible to childhood cancers. Dicer is phosphorylated by the ERK-MAP kinase pathway and because this pathway is activ...

journal_title：Cancer research

authors： Aryal NK,Pant V,Wasylishen AR,Rimel BJ,Baseler L,El-Naggar AK,Mutch DG,Goodfellow PJ,Arur S,Lozano G

更新日期：2019-05-15 00:00:00

abstract：:Blood coagulation factor VII (fVII) is physiologically synthesized in the liver and released into the blood. Binding of fVII to tissue factor (TF) at sites of vascular injury triggers coagulation and hemostasis. TF/fVIIa complex formation on the surface of cancer cells plays important roles in cancer biology. Although...

journal_title：Cancer research

authors： Koizume S,Jin MS,Miyagi E,Hirahara F,Nakamura Y,Piao JH,Asai A,Yoshida A,Tsuchiya E,Ruf W,Miyagi Y

更新日期：2006-10-01 00:00:00

abstract：:Transcription factor oncogenes such as GLI and c-MYC are central to the pathogenesis of human tumors. GLI encodes a zinc finger protein that is activated by Sonic Hedgehog signaling. Mutations in this pathway induce GLI expression in basal cell carcinoma, and expression of GLI in mice is sufficient to induce these ski...

journal_title：Cancer research

authors： Louro ID,Bailey EC,Li X,South LS,McKie-Bell PR,Yoder BK,Huang CC,Johnson MR,Hill AE,Johnson RL,Ruppert JM

更新日期：2002-10-15 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00

abstract：:In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model. To ascertain these data, 5-FUra (30 mg/kg) was given as a bolus into either a systemic vein (femoral vei...

journal_title：Cancer research

authors： Didolkar MS,Covell DG,Jackson AJ,Walker AP,Kalidindi SR

更新日期：1984-11-01 00:00:00

abstract：:Human breast epithelial cells cultured from milk have been transformed with SV40. Indirect immunofluorescence tests using monoclonal antibodies show that cells from clones grown in soft agar have SV40 large T-antigen in their nuclei and epithelia-specific tonofilament antigens on their intermediate filaments. In prima...

journal_title：Cancer research

authors： Chang SE,Keen J,Lane EB,Taylor-Papadimitriou J

更新日期：1982-05-01 00:00:00