Abstract：
:We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We have compared instability measured by this method with that measured by inter-(simple sequence repeat) PCR and microsatellite instability assays. Instability quantitated by fractional allelic loss rates was found to be independent of that detected by microsatellite instability analyses but was weakly associated with that measured by inter-(simple sequence repeat) PCR. A set of seven loci were identified that were most strongly associated with elevated rates of fractional allelic loss and/or inter-(simple sequence repeat) PCR instability; these seven loci were on chromosomes 3, 8, 11, 13, 14, 18, and 20. A lesser association was seen with two loci flanking p53 on chromosome 17. Coordinate loss patterns for these loci suggest that at least two separate sets of cooperating loci exist for intrachromosomal genomic instability in human colorectal cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Anderson GR,Brenner BM,Swede H,Chen N,Henry WM,Conroy JM,Karpenko MJ,Issa JP,Bartos JD,Brunelle JK,Jahreis GP,Kahlenberg MS,Basik M,Sait S,Rodriguez-Bigas MA,Nowak NJ,Petrelli NJ,Shows TB,Stoler DLsubject
Has Abstractpub_date
2001-11-15 00:00:00pages
8274-83issue
22eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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