Immunohistochemical analysis of human pulmonary carcinomas using monoclonal antibody 44-3A6.

abstract：:Eighty-five antibodies recognizing breast cancer-selective antigens were conjugated to ricin toxin A-chain using a disulfide linkage. The cytotoxicities of the resulting immunotoxins were determined on breast cancer cells and normal human fibroblasts. Twenty-four antibodies formed immunotoxins that were toxic to at le...

journal_title：Cancer research

authors： Bjorn MJ,Ring D,Frankel A

更新日期：1985-03-01 00:00:00

abstract：:The amino acid fucosides of tumorigenic and nontumorigenic mouse mammary gland-derived cells were studied. The cells examined included tumorigenic cell lines derived from mammary carcinomas of the following etiologies: induction by hormone; virus; and chemical carcinogen. Also studied were cells derived from normal ma...

journal_title：Cancer research

authors： Steiner MR,Richards CS,Butel JS,Medina D

更新日期：1983-06-01 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:Maintenance of long term culture and conventional xenografting of early B-lineage acute lymphoblastic leukemia cells is most difficult. Matrigel, a solubilized attachment matrix shown to aid growth of anchorage dependent solid tumors, was studied in heterotransplantation. Material for xenografting was derived from 5 p...

journal_title：Cancer research

authors： Sterling-Levis K,White L,Trickett AE,Gramacho C,Pittman SM,Tobias V

更新日期：1993-03-15 00:00:00

abstract：:The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the intron-exon junctions....

journal_title：Cancer research

authors： Nishida N,Fukuda Y,Kokuryu H,Toguchida J,Yandell DW,Ikenega M,Imura H,Ishizaki K

更新日期：1993-01-15 00:00:00

abstract：:ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other three members of the EGFR family (i.e., EGFR, ERBB2/HER2/NEU, and ERBB3), which are associated with aggressive forms of human cancers, ERBB4 expression ...

journal_title：Cancer research

authors： Naresh A,Long W,Vidal GA,Wimley WC,Marrero L,Sartor CI,Tovey S,Cooke TG,Bartlett JM,Jones FE

更新日期：2006-06-15 00:00:00

abstract：:To identify genetic alterations underlying rectal carcinogenesis, we used global gene expression profiling of a series of 17 locally advanced rectal adenocarcinomas and 20 normal rectal mucosa biopsies on oligonucleotide arrays. A total of 351 genes were differentially expressed (P < 1.0e-7) between normal rectal muco...

journal_title：Cancer research

authors： Grade M,Ghadimi BM,Varma S,Simon R,Wangsa D,Barenboim-Stapleton L,Liersch T,Becker H,Ried T,Difilippantonio MJ

更新日期：2006-01-01 00:00:00

abstract：:CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammat...

journal_title：Cancer research

authors： Marelli G,Erreni M,Anselmo A,Taverniti V,Guglielmetti S,Mantovani A,Allavena P

更新日期：2017-08-15 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:The concentration of estrogenic, androgenic, progestational, and adrenocortical steroid hormones in body fluids of mature intact Sprague-Dawley female rats was increased by s.c. implantation of 5 to 7 mg NaCl pellets containing 1 to 20% steroid 48 hr before administration p.o. of either 7,12-dimethylbenz(a) anthracene...

journal_title：Cancer research

authors： Lemon HM

更新日期：1975-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have increased prostaglandin expression (PGE2). Many lung cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and biosynthesize 12(S)-hy...

journal_title：Cancer research

authors： Soriano AF,Helfrich B,Chan DC,Heasley LE,Bunn PA Jr,Chou TC

更新日期：1999-12-15 00:00:00

abstract：:Previous studies have documented the roles of transport via the reduced folate carrier, retention via polyglutamylation, and increased levels of the target enzyme, dihydrofolate reductase in sensitivity to methotrexate. Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, fola...

journal_title：Cancer research

authors： Vazquez A,Tedeschi PM,Bertino JR

更新日期：2013-01-15 00:00:00

abstract：:As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes to the lung, and induces a nonspecific immunosuppression in the host. Using this breast medullar adenocarcinoma model, a therapy consisting of a single moderat...

journal_title：Cancer research

authors： Ewens A,Luo L,Berleth E,Alderfer J,Wollman R,Hafeez BB,Kanter P,Mihich E,Ehrke MJ

更新日期：2006-05-15 00:00:00

abstract：:Two sublines, SCLC-MOA1 (MOA1) and SCLC-MOA2 (MOA2), were established from the SCLC-MO cell line, which was originally derived from an oat cell type of small cell lung carcinoma (SCLC). SCLC-MO showed typical culture morphology of SCLC, growing as tightly packed floating aggregates, while both MOA1 and MOA2 grew as a ...

journal_title：Cancer research

authors： Watanabe H,Takahashi T,Ueda R,Utsumi KR,Sato T,Ariyoshi Y,Ota K,Obata Y,Takahashi T

更新日期：1988-05-01 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:Mice were treated with several different potentially carcinogenic components of tobacco smoke. The chemicals used were: 4-aminobiphenyl and aniline-HCl, which are found in high concentrations in sidestream tobacco smoke; hydrazine sulfate, which is found in high concentrations in mainstream tobacco smoke; and 2-methyl...

journal_title：Cancer research

authors： Sonnenfeld G,Hudgens RW

更新日期：1983-10-01 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A...

journal_title：Cancer research

authors： Fukumoto T,Fatkhutdinov N,Zundell JA,Tcyganov EN,Nacarelli T,Karakashev S,Wu S,Liu Q,Gabrilovich DI,Zhang R

更新日期：2019-11-01 00:00:00

abstract：:Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysin...

journal_title：Cancer research

authors： Chiang YC,Park IY,Terzo EA,Tripathi DN,Mason FM,Fahey CC,Karki M,Shuster CB,Sohn BH,Chowdhury P,Powell RT,Ohi R,Tsai YS,de Cubas AA,Khan A,Davis IJ,Strahl BD,Parker JS,Dere R,Walker CL,Rathmell WK

更新日期：2018-06-15 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins,...

journal_title：Cancer research

authors： Tome ME,Baker AF,Powis G,Payne CM,Briehl MM

更新日期：2001-03-15 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage-activated signaling pathway, which regulates cellular resistance to DNA cross-linking agen...

journal_title：Cancer research

authors： Jacquemont C,Taniguchi T

更新日期：2007-08-01 00:00:00

abstract：:Methyl methanesulfonate (MMS), a direct-acting alkylating agent, is a strong brain carcinogen but a poor hepatocarcinogen in rats. To elucidate the mechanism(s) leading to tissue-specific carcinogenesis in response to MMS, we compared the activation of the stress-activated protein kinases (SAPKs), the c-Jun NH2-termin...

journal_title：Cancer research

authors： Suh Y,Kang UG,Kim YS,Kim WH,Park SC,Park JB

更新日期：2000-09-15 00:00:00

abstract：:The expressions of albumin and alpha-fetoprotein (AFP) genes were studied in early preneoplastic liver lesions produced by the Solt-Farber protocol using "in situ" hybridization with single stranded RNA probes. In normal rat liver, albumin was expressed at a lower level in the centrilobular than in the periportal area...

journal_title：Cancer research

authors： Evarts RP,Nagy P,Marsden E,Thorgeirsson SS

更新日期：1987-10-15 00:00:00

abstract：:Loss of chromosome 19p is one of the most frequent allelic imbalances in esophageal squamous cell carcinoma (ESCC), suggesting the existence of one or more tumor suppressor genes within this region. In this study, we investigated a role in ESCCs for a candidate tumor suppressor gene located at 19p13.3, the Ras-like sm...

journal_title：Cancer research

authors： Zhu YH,Fu L,Chen L,Qin YR,Liu H,Xie F,Zeng T,Dong SS,Li J,Li Y,Dai Y,Xie D,Guan XY

更新日期：2013-04-01 00:00:00

abstract：:We have studied the effects of tamoxifen on the cell cycle kinetics of the endocrine-responsive MCF-7 human breast cancer cells. Tamoxifen inhibits proliferation of MCF-7 cells. The tritiated thymidine labeling index is markedly reduced by tamoxifen, indicating a reduction in the fraction of cells in S phase. Flow cyt...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Clark GM,Trent JM

更新日期：1983-08-01 00:00:00

abstract：:Dissemination of tumor to the leptomeninges and cerebrospinal fluid represents a common pattern of metastasis for many cancers; however, few chemotherapeutic agents are available for intrathecal (i.t.) use and treatment results are often poor. We studied the neurotoxicity and pharmacokinetics of i.t. 4-hydroperoxycycl...

journal_title：Cancer research

authors： Phillips PC,Than TT,Cork LC,Hilton J,Carson BS,Colvin OM,Grochow LB

更新日期：1992-11-15 00:00:00

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00