In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.

abstract：:Identification of proteins that are involved in the sensitivity of radiotherapy of cancers is important to enhance the response to cancer treatment. Expression of TAp73 is associated with the sensitivity of radiotherapy in cervical cancer patients, suggesting it plays an important role in controlling radiosensitivity....

journal_title：Cancer research

authors： Leung TH,Ngan HY

更新日期：2010-08-15 00:00:00

abstract：:Distal enhancers have recently emerged as a common mode of gene regulation for several transcription factors, including estrogen and androgen receptors, the two key regulators of breast and prostate cancer major subtypes. Despite the rapid success in genome-wide annotation of estrogen receptor-alpha (ERalpha) binding ...

journal_title：Cancer research

authors： Chan CS,Song JS

更新日期：2008-11-01 00:00:00

abstract：:We demonstrated previously elevated caveolin-1 expression in metastatic mouse and human prostate cancer cells both in vitro and in vivo. In this study, we analyzed its prognostic value for progression of clinically confined human prostate cancer. Immunohistochemical staining with a caveolin-1-specific antibody was per...

journal_title：Cancer research

authors： Yang G,Truong LD,Wheeler TM,Thompson TC

更新日期：1999-11-15 00:00:00

abstract：:The antitumor activity of IFN-alpha is well established. However, the role of the plasmacytoid dendritic cell (PDC), the major producer of IFN-alpha upon viral infection, in tumor biology is unknown. We sought to study the presence and function of PDC in a human solid tumor. Here, we demonstrate that PDCs infiltrate t...

journal_title：Cancer research

authors： Hartmann E,Wollenberg B,Rothenfusser S,Wagner M,Wellisch D,Mack B,Giese T,Gires O,Endres S,Hartmann G

更新日期：2003-10-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer is associated with inherited defects in DNA mismatch repair. Clinical variation even in cases with identical predisposing mutations suggests the existence of other factors contributing to the phenotype. We addressed the modifying role of the common A/G polymorphism in exon 4 a...

journal_title：Cancer research

authors： Bala S,Peltomäki P

更新日期：2001-08-15 00:00:00

abstract：:Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibiti...

journal_title：Cancer research

authors： Mestre-Farrera A,Bruch-Oms M,Peña R,Rodríguez-Morató J,Alba-Castellón L,Comerma L,Quintela-Fandino M,Duñach M,Baulida J,Pozo ÓJ,García de Herreros A

更新日期：2021-01-15 00:00:00

abstract：:Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in the global genome repair subpathway of NER, CS patients do not have an elevated cancer incidence. To determine t...

journal_title：Cancer research

authors： Wijnhoven SW,Kool HJ,van Oostrom CT,Beems RB,Mullenders LH,van Zeeland AA,van der Horst GT,Vrieling H,van Steeg H

更新日期：2000-10-15 00:00:00

abstract：:L1210 murine leukemia cells were treated in vitro with the novel antineoplastic agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one (M&B 39565), and its interaction with cellular DNA was assessed by alkaline elution. DNA interstrand cross-link and DNA-protein cross-link formation was quantifi...

journal_title：Cancer research

authors： Gibson NW,Erickson LC,Hickman JA

更新日期：1984-05-01 00:00:00

abstract：:This position paper summarizes the overwhelming evidence that tobacco smoking is the cause of 30 to 40% of deaths from cancer. The focus is on lung cancer because of the sheer magnitude of this disease in males and the likelihood of a similar epidemic in females. There are two categories of evidence that indicate smok...

journal_title：Cancer research

authors： Loeb LA,Ernster VL,Warner KE,Abbotts J,Laszlo J

更新日期：1984-12-01 00:00:00

abstract：:The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on Notch signaling in tumor cells expressing Notch receptors remain, however, largely unknown. Here, we report that escape of human T-c...

journal_title：Cancer research

authors： Indraccolo S,Minuzzo S,Masiero M,Pusceddu I,Persano L,Moserle L,Reboldi A,Favaro E,Mecarozzi M,Di Mario G,Screpanti I,Ponzoni M,Doglioni C,Amadori A

更新日期：2009-02-15 00:00:00

abstract：:The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. The hybrid cells were produced by fusion of a normal and tumor cell. The parental lines...

journal_title：Cancer research

authors： Sanford KK,Parshad R,Stanbridge EJ,Frost JK,Jones GM,Wilkinson JE,Tarone RE

更新日期：1986-04-01 00:00:00

abstract：:Previous studies from our laboratory have shown that the activation of G(2)-M checkpoint after exposure of MCF-7 breast cancer cells to gamma-irradiation (IR) is dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Studies presented in this report indicate that IR exposure of MC...

journal_title：Cancer research

authors： Yan Y,Black CP,Cao PT,Haferbier JL,Kolb RH,Spieker RS,Ristow AM,Cowan KH

更新日期：2008-07-01 00:00:00

abstract：:Clinical trials have utilized intermittent diethylstilbestrol diphosphate (DES) therapy in advanced symptomatic prostatic carcinoma to diminish the morbidity of standard endocrine therapy. To determine the effect of intermittent DES administration on the Dunning R3327 rat prostatic adenocarcinoma 60 days following tum...

journal_title：Cancer research

authors： Russo P,Liguori G,Heston WD,Huryk R,Yang CR,Fair WR,Whitmore WF,Herr HW

更新日期：1987-11-15 00:00:00

abstract：:WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

journal_title：Cancer research

authors： Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

更新日期：1997-04-15 00:00:00

abstract：:Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expressi...

journal_title：Cancer research

authors： Beckmann PJ,Larson JD,Larsson AT,Ostergaard JP,Wagner S,Rahrmann EP,Shamsan GA,Otto GM,Williams RL,Wang J,Lee C,Tschida BR,Das P,Dubuc AM,Moriarity BS,Picard D,Wu X,Rodriguez FJ,Rosemarie Q,Krebs RD,Molan AM,Dem

更新日期：2019-03-01 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and subsequent poly(ADP-ribose)-dependent DNA repair. PARP-1 inhibition is a promising new way to sel...

journal_title：Cancer research

authors： Steffen JD,Tholey RM,Langelier MF,Planck JL,Schiewer MJ,Lal S,Bildzukewicz NA,Yeo CJ,Knudsen KE,Brody JR,Pascal JM

更新日期：2014-01-01 00:00:00

abstract：:Given that there are millions of single-nucleotide polymorphisms (SNPs) in the entire human genome, a major difficulty faced by scientists in planning costly population-based genotyping is to choose target SNPs that are most likely to affect phenotypic functions and ultimately contribute to disease development. Althou...

journal_title：Cancer research

authors： Zhu Y,Spitz MR,Amos CI,Lin J,Schabath MB,Wu X

更新日期：2004-03-15 00:00:00

abstract：:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

journal_title：Cancer research

authors： Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

更新日期：1993-11-01 00:00:00

abstract：:The thiopurines 6-thioguanine (6TG) and 6-mercaptopurine (6MP) are cytotoxic to proliferating cells by a mechanism involving incorporation into DNA via the purine salvage pathway, and resistance to these agents can be conferred by lack of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase. Howev...

journal_title：Cancer research

authors： Morgan CJ,Chawdry RN,Smith AR,Siravo-Sagraves G,Trewyn RW

更新日期：1994-10-15 00:00:00

abstract：:O6-Alkylguanine, a DNA adduct formed by nitrosoureas, becomes the site of a point mutation during DNA synthesis by preferentially base mispairing with thymine rather than correctly base pairing with cytosine. To repair this adduct, cells contain a limited amount of O6-alkylguanine-DNA alkyltransferase (alkyltransferas...

journal_title：Cancer research

authors： Gerson SL,Trey JE,Miller K,Benjamin E

更新日期：1987-01-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:The urokinase-type plasminogen activator (u-PA) was used to study 96 cases of lung adenocarcinoma and 49 cases of lymph node metastatic adenocarcinoma. We made use of the immunohistochemistry of paraffinized samples. u-PA was detected in the cytoplasm of tumor cells, and the number of positive cells was higher in pati...

journal_title：Cancer research

authors： Oka T,Ishida T,Nishino T,Sugimachi K

更新日期：1991-07-01 00:00:00

abstract：:We have previously shown that interleukin 2 (IL-2) synergizes with interferon alpha (IFN-alpha) in mediating the regression of established pulmonary and hepatic metastases and the reduction of intradermal tumor in various murine tumor models. To understand the mechanism of synergy, we have examined lymphoid cell proli...

journal_title：Cancer research

authors： Puri RK,Travis WD,Rosenberg SA

更新日期：1990-09-01 00:00:00

abstract：:Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignan...

journal_title：Cancer research

authors： Fava G,Alpini G,Rychlicki C,Saccomanno S,DeMorrow S,Trozzi L,Candelaresi C,Venter J,Di Sario A,Marzioni M,Bearzi I,Glaser S,Alvaro D,Marucci L,Francis H,Svegliati-Baroni G,Benedetti A

更新日期：2008-08-15 00:00:00

abstract：:The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We hypothesize that tum...

journal_title：Cancer research

authors： Nannuru KC,Futakuchi M,Varney ML,Vincent TM,Marcusson EG,Singh RK

更新日期：2010-05-01 00:00:00

abstract：:We studied N-myc RNA by in situ hybridization and S1 nuclease protection analysis in human fetal cerebrum, retina, lung, liver, and placenta during the second trimester. High levels of N-myc RNA were found in the early fetal cerebral germinal layer and the primordial cortex, with lower levels in the intermediate layer...

journal_title：Cancer research

authors： Grady EF,Schwab M,Rosenau W

更新日期：1987-06-01 00:00:00

abstract：:Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

journal_title：Cancer research

authors： Ways DK,Dodd RC,Earp HS

更新日期：1987-07-01 00:00:00

abstract：:TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study, we evaluate the ability of the Evolutionary Action score...

journal_title：Cancer research

authors： Osman AA,Neskey DM,Katsonis P,Patel AA,Ward AM,Hsu TK,Hicks SC,McDonald TO,Ow TJ,Alves MO,Pickering CR,Skinner HD,Zhao M,Sturgis EM,Kies MS,El-Naggar A,Perrone F,Licitra L,Bossi P,Kimmel M,Frederick MJ,Lichtarge

更新日期：2015-04-01 00:00:00

abstract：:Invasive lobular and ductal breast tumors have distinct histologies and clinical presentation. Other than altered expression of E-cadherin, little is known about the underlying biology that distinguishes the tumor subtypes. We used cDNA microarrays to identify genes differentially expressed between lobular and ductal ...

journal_title：Cancer research

authors： Korkola JE,DeVries S,Fridlyand J,Hwang ES,Estep AL,Chen YY,Chew KL,Dairkee SH,Jensen RM,Waldman FM

更新日期：2003-11-01 00:00:00