CCCTC-binding factor confines the distal action of estrogen receptor.

Abstract:

:Distal enhancers have recently emerged as a common mode of gene regulation for several transcription factors, including estrogen and androgen receptors, the two key regulators of breast and prostate cancer major subtypes. Despite the rapid success in genome-wide annotation of estrogen receptor-alpha (ERalpha) binding sites in cell lines, the precise mechanism governing the gene-to-enhancer association is still unknown and no quantitative model that can predict the estrogen responsiveness of genes has been hitherto proposed. This article presents an integrative genomics approach to construct a predictive model that can explain more than 70% of estrogen-induced expression profiles. The proposed method combines a recent map of the insulator protein CCCTC-binding factor (CTCF) with previous ER location studies and expression profiling in the presence of the translation inhibitor cycloheximide, providing evidence that CTCF partitions the human genome into distinct ER-regulatory blocks. It is shown that estrogen-responsive genes with a decreased transcription level (down-regulated genes) have a markedly different relative distribution of ER binding sites compared with those with an increased transcription level (up-regulated genes). Finally, Bayesian belief networks are constructed to quantify the effects of ER-binding distance from genes as well as the insulating effects of CTCF on the estrogen responsiveness of genes. This work thus represents a stride toward understanding and predicting the distal activities of steroid hormone nuclear receptors.

journal_name

Cancer Res

journal_title

Cancer research

authors

Chan CS,Song JS

doi

10.1158/0008-5472.CAN-08-2632

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

9041-9

issue

21

eissn

0008-5472

issn

1538-7445

pii

68/21/9041

journal_volume

68

pub_type

杂志文章
  • Inhibition of ribonucleotide reductase activity and nucleic acid synthesis in tumor cells by the dialdehyde derivatives of inosine (NSC 118994) and inosinic acid.

    abstract::Periodate-oxidized inosine (Inox; NSC 118994) and periodate-oxidized 5'-inosinic acid (PI-IMP) were prepared and studied for their effects on ribonucleotide reductase activity in partially purified extracts from Ehrlich tumor cells and on nucleic acid synthesis in intact tumor cells in culture. Ribonucleotide reductas...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Cory JG,Mansell MM,Whitford TW Jr

    更新日期:1976-09-01 00:00:00

  • Carcinoembryonic antigen-related cell adhesion molecule 1a-4L suppression of rat hepatocellular carcinomas.

    abstract::Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-2841

    authors: Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

    更新日期:2005-12-01 00:00:00

  • Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat.

    abstract::The relative effectiveness of either sodium selenite or selenomethionine in the inhibition of mammary carcinogenesis was studied in virgin female Sprague-Dawley rats. In one experiment, rats were given 50 mg of 1-methyl-1-nitrosourea per kg of body weight s.c. at 50 days of age. Beginning 7 days post-1-methyl-1-nitros...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Thompson HJ,Meeker LD,Kokoska S

    更新日期:1984-07-01 00:00:00

  • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion.

    abstract::Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA), strongly induced by hypoxia. CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis. An inhibitor of CAs, acetazolamide has been reported to inhibit invasion. We used RNA interference (...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-03-2224

    authors: Robertson N,Potter C,Harris AL

    更新日期:2004-09-01 00:00:00

  • Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine.

    abstract::Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue culture and in normal and neoplastic t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Chan WS,Marshall JF,Svensen R,Bedwell J,Hart IR

    更新日期:1990-08-01 00:00:00

  • Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor calyculin A.

    abstract::Effects of calyculin A, a potent inhibitor of protein phosphatases 1 and 2A, on X-ray cell killing and chromatin structure were studied using cultured mammalian cells (BHK21). Calyculin A at concentrations of 2.5-20 nM enhanced X-ray cell killing when exponentially growing BHK21 cells were treated with calyculin A for...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nakamura K,Antoku S

    更新日期:1994-04-15 00:00:00

  • Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

    abstract::To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

    更新日期:1993-11-01 00:00:00

  • Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro.

    abstract::Brain tumors are thought to originate from stem/progenitor cell populations that acquire specific genetic mutations. Although current preclinical models have relevance to human pathogenesis, most do not recapitulate the histogenesis of the human disease. Recently, a large series of human gliomas and medulloblastomas w...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-1299

    authors: Henriquez NV,Forshew T,Tatevossian R,Ellis M,Richard-Loendt A,Rogers H,Jacques TS,Reitboeck PG,Pearce K,Sheer D,Grundy RG,Brandner S

    更新日期:2013-09-15 00:00:00

  • Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis.

    abstract::This report describes the development and validation of quantitative microsatellite analysis (QuMA) for rapid measurement of relative DNA sequence copy number. In QuMA, the copy number of a test locus relative to a pooled reference is assessed using quantitative, real-time PCR amplification of loci carrying simple seq...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ginzinger DG,Godfrey TE,Nigro J,Moore DH 2nd,Suzuki S,Pallavicini MG,Gray JW,Jensen RH

    更新日期:2000-10-01 00:00:00

  • Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.

    abstract::Neoplastic liver nodules and hepatocellular carcinomas (HCCs) were induced, by "resistant hepatocyte" model, 32 and 70 weeks after initiation with diethylnitrosamine, respectively, in F344 Brown Norway (BN), and (BNxF344)F1 rats. Nodule number/liver (N) did not significantly differ among rat strains, whereas nodule me...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: De Miglio MR,Canzian F,Pascale RM,Simile MM,Muroni MR,Calvisi D,Romeo G,Feo F

    更新日期:1999-09-15 00:00:00

  • Intraperitoneal immunoconjugates.

    abstract::Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athym...

    journal_title:Cancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Griffin TW,Collins J,Bokhari F,Stochl M,Brill AB,Ito T,Emond G,Sands H

    更新日期:1990-02-01 00:00:00

  • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

    abstract::The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Powis G,Seewald MJ,Gratas C,Melder D,Riebow J,Modest EJ

    更新日期:1992-05-15 00:00:00

  • Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response.

    abstract::We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human cancer cells and tumors. Survivin inhibits caspase-9, blocks apoptosis, and is associated with resistance to chemotherapy and radiation. Survivin is a client p...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-4785

    authors: Ferrario A,Rucker N,Wong S,Luna M,Gomer CJ

    更新日期:2007-05-15 00:00:00

  • Medical history and primary liver cancer.

    abstract::The relationship between selected aspects of medical history and the risk of primary liver cancer was analyzed in a hospital-based case-control study conducted in Northern Italy on 242 patients with histologically or serologically confirmed hepatocellular carcinoma and 1169 controls in hospital for acute, nonneoplasti...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: La Vecchia C,Negri E,D'Avanzo B,Boyle P,Franceschi S

    更新日期:1990-10-01 00:00:00

  • Characterization of liver-type alkaline phosphatase from human gastric carcinoma cells (KMK-2) in vitro.

    abstract::Alkaline phosphatase was extracted from human gastric carcinoma cells (KMK-2) under long-term culture, and its biochemical and biological properties were investigated. The enzyme was extremely heat labile and was inhibited significantly by L-homoarginine, but only slightly by L-phenylalanine, so that it was classified...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tokumitsu SI,Tokumitsu K,Kohnoe K,Takeuchi T

    更新日期:1979-11-01 00:00:00

  • Leukemia derived growth factors produced by human malignant T-lymphoid cell lines.

    abstract::An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

    更新日期:1986-03-01 00:00:00

  • Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.

    abstract::Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-18-0441

    authors: Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

    更新日期:2018-10-01 00:00:00

  • Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting.

    abstract::In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization as a result of increased proteolysis. Administration of the beta2-agonist formoterol to both rats and mice bearing highly cachectic tumors resulted in an important reversal of the muscle-wasting process. The anti-wasting effec...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-0425

    authors: Busquets S,Figueras MT,Fuster G,Almendro V,Moore-Carrasco R,Ametller E,Argilés JM,López-Soriano FJ

    更新日期:2004-09-15 00:00:00

  • Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.

    abstract::The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-1265

    authors: Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

    更新日期:2006-04-15 00:00:00

  • The white adipose tissue used in lipotransfer procedures is a rich reservoir of CD34+ progenitors able to promote cancer progression.

    abstract::Previous studies have suggested a "catalytic role" in neoplastic angiogenesis and cancer progression for bone marrow-derived endothelial progenitor cells (EPC). However, preclinical and clinical studies have shown that the quantitative role of marrow-derived EPCs in cancer vascularization is extremely variable. We hav...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-1739

    authors: Martin-Padura I,Gregato G,Marighetti P,Mancuso P,Calleri A,Corsini C,Pruneri G,Manzotti M,Lohsiriwat V,Rietjens M,Petit JY,Bertolini F

    更新日期:2012-01-01 00:00:00

  • Exploiting DNA Replication Stress for Cancer Treatment.

    abstract::Complete and accurate DNA replication is fundamental to cellular proliferation and genome stability. Obstacles that delay, prevent, or terminate DNA replication cause the phenomena termed DNA replication stress. Cancer cells exhibit chronic replication stress due to the loss of proteins that protect or repair stressed...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-18-3631

    authors: Ubhi T,Brown GW

    更新日期:2019-04-15 00:00:00

  • Survival differences exhibited by normal and transformed rat liver epithelial cell lines in the aggregate form.

    abstract::Normal and transformed rat liver epithelial cell lines exhibited differences in the ability to survive in the aggregate form. Normal rat liver epithelial cells in the aggregate form underwent a rapid decline in the number of viable cells, while counterpart transformed epithelial cells exhibited an ability to survive a...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Steuer AF,Hentosh PM,Diamond L,Ting RC

    更新日期:1977-06-01 00:00:00

  • Integration of somatic deletion analysis of prostate cancers and germline linkage analysis of prostate cancer families reveals two small consensus regions for prostate cancer genes at 8p.

    abstract::The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated region...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-4570

    authors: Chang BL,Liu W,Sun J,Dimitrov L,Li T,Turner AR,Zheng SL,Isaacs WB,Xu J

    更新日期:2007-05-01 00:00:00

  • SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.

    abstract::The capacity for tumor cells to metastasize efficiently is directly linked to their ability to colonize secondary sites. Here we identify Six2, a developmental transcription factor, as a critical regulator of a breast cancer stem cell program that enables metastatic colonization. In several triple-negative breast canc...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-18-1791

    authors: Oliphant MUJ,Vincent MY,Galbraith MD,Pandey A,Zaberezhnyy V,Rudra P,Johnson KR,Costello JC,Ghosh D,DeGregori J,Espinosa JM,Ford HL

    更新日期:2019-02-15 00:00:00

  • Cryptic epitopes on alpha-fetoprotein induce spontaneous immune responses in hepatocellular carcinoma, liver cirrhosis, and chronic hepatitis patients.

    abstract::To determine alpha-fetoprotein (AFP) immunogenicity in vivo, the presence of antibodies in sera of 60 hepatocellular carcinoma, 15 liver cirrhosis, and 15 chronic hepatitis patients was evaluated by Western blotting and immunoprecipitation analyses using purified human AFP. High titers of anti-AFP immunoglobulins were...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bei R,Budillon A,Reale MG,Capuano G,Pomponi D,Budillon G,Frati L,Muraro R

    更新日期:1999-11-01 00:00:00

  • Anti-BA46 monoclonal antibody Mc3: humanization using a novel positional consensus and in vivo and in vitro characterization.

    abstract::Mc3 is a murine mAb that is highly effective in treating breast tumors in experimental radioimmunotherapy. Mc3 binds to BA46, a 46-kDa glycoprotein of the human milk fat globule membrane that is also expressed in breast carcinoma cells. We cloned and sequenced cDNAs encoding the variable regions of Mc3 and constructed...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Couto JR,Blank EW,Peterson JA,Ceriani RL

    更新日期:1995-04-15 00:00:00

  • Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.

    abstract::A structure-activity relationship study was carried out to identify structural features in arylalkyl and alkyl isothiocyanates that are associated with the inhibitory potency of these compounds against lung tumorigenesis induced in A/J mice by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Jiao D,Eklind KI,Choi CI,Desai DH,Amin SG,Chung FL

    更新日期:1994-08-15 00:00:00

  • Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

    abstract::Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-4213

    authors: Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

    更新日期:2013-05-01 00:00:00

  • In vivo radiolocalization of antiosteogenic sarcoma monoclonal antibodies in osteogenic sarcoma xenografts.

    abstract::Monoclonal antibodies Ost6 and Ost7 (mouse Immunoglobulin G1) to human osteogenic sarcoma were isolated from ascitic fluid and labeled with radioiodine. After injection into athymic nu/nu mice with s.c. xenografts of human osteogenic sarcoma, the uptake of radioactivity in tumors, visceral organs, and blood was determ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nakamura T,Sakahara H,Hosoi S,Yamamuro T,Higashi S,Mikawa H,Endo K,Toyama S

    更新日期:1984-05-01 00:00:00

  • Preclinical study of sequential tumor necrosis factor and interleukin 2 in the treatment of spontaneous canine neoplasms.

    abstract::Recombinant human tumor necrosis factor and recombinant human interleukin 2 were administered in a sequential schedule to 30 dogs with a variety of spontaneous neoplasms. Dose escalation of both drugs was performed, and a maximally tolerated dose of recombinant human tumor necrosis factor of 125 mg/m2 i.v. for 3 days,...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Moore AS,Theilen GH,Newell AD,Madewell BR,Rudolf AR

    更新日期:1991-01-01 00:00:00