Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell.

abstract：:Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single constitutively expressed control gene. However, in recent years, it has become...

journal_title：Cancer research

authors： Andersen CL,Jensen JL,Ørntoft TF

更新日期：2004-08-01 00:00:00

abstract：:Noscapine, a benzylisoquinoline alkaloid derived from opium, was recently reported to exhibit activity against a variety of cancers through a poorly understood mechanism. Because the transcription factor NF-kappaB has been linked with inflammation, survival, proliferation, invasion, and angiogenesis in tumors, we hypo...

journal_title：Cancer research

authors： Sung B,Ahn KS,Aggarwal BB

更新日期：2010-04-15 00:00:00

abstract：:The human checkpoint kinase 2 (Chk2) plays a central role in regulation of the cellular response to DNA damage, resulting in cell cycle arrest, DNA repair, or apoptosis depending on severity of DNA damage and the cellular context. Chk2 inhibitors are being developed as sensitizers for chemotherapeutic agents. In contr...

journal_title：Cancer research

authors： Chen CR,Wang W,Rogoff HA,Li X,Mang W,Li CJ

更新日期：2005-07-15 00:00:00

abstract：:Rational in vivo application of monoclonal antibodies for diagnosis and therapy of cancer requires an understanding of both the global and microscopic pharmacology of macromolecular ligands. Here, we introduce a new mathematical model for antibody distribution into small, prevascular, densely packed nodules (represent...

journal_title：Cancer research

authors： van Osdol W,Fujimori K,Weinstein JN

更新日期：1991-09-15 00:00:00

abstract：:Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribute to the therapeutic ...

journal_title：Cancer research

authors： Reim F,Dombrowski Y,Ritter C,Buttmann M,Häusler S,Ossadnik M,Krockenberger M,Beier D,Beier CP,Dietl J,Becker JC,Hönig A,Wischhusen J

更新日期：2009-10-15 00:00:00

abstract：:Reconstituted basement membrane matrix (Matrigel) has been utilized for in vitro assay of tumor cell invasion in recent years. In the conventional chamber for the invasion assay, however, a large number of cells passed easily through the center of the Matrigel-coated filter because the Matrigel layer could not be comp...

journal_title：Cancer research

authors： Imamura H,Takao S,Aikou T

更新日期：1994-07-01 00:00:00

abstract：:To identify methylation-mediated silencing of genes in hepatocellular carcinoma (HCC), we surveyed genes induced by treatment with 5-aza-2'-deoxycytidine (5-Aza-CdR) in six human hepatoma cell lines using cDNA microarray analysis and determined the methylation status of 5' CpG islands by bisulfite DNA sequencing or me...

journal_title：Cancer research

authors： Fukai K,Yokosuka O,Chiba T,Hirasawa Y,Tada M,Imazeki F,Kataoka H,Saisho H

更新日期：2003-12-15 00:00:00

abstract：:Despite some advances, pancreatic ductal adenocarcinoma (PDAC) remains generally refractory to current treatments. Desmoplastic stroma, a consistent hallmark of PDAC, has emerged as a major source of therapeutic resistance and thus potentially promising targets for improved treatment. The glycan-binding protein galect...

journal_title：Cancer research

authors： Martínez-Bosch N,Fernández-Barrena MG,Moreno M,Ortiz-Zapater E,Munné-Collado J,Iglesias M,André S,Gabius HJ,Hwang RF,Poirier F,Navas C,Guerra C,Fernández-Zapico ME,Navarro P

更新日期：2014-07-01 00:00:00

abstract：:Intercellular communication was compared in early passage cultures of human mammary epithelial cells (HMEC) from normal and malignant breast tissues and immortalized nontumorigenic human breast cell lines (184A1 and 184B5). A clonogenic assay for the cell-mediated transfer of toxic metabolites of 6-thioguanine (TG) be...

journal_title：Cancer research

authors： Eldridge SR,Martens TW,Sattler CA,Gould MN

更新日期：1989-08-01 00:00:00

abstract：:The ingestion of high levels of fats, especially unsaturated fats, has been shown to enhance carcinogenesis in a variety of experimental model systems. Recently attention has focused upon the unsaturated linoleic fatty acid (18:2 omega 6) as a key component for this postinitiation enhancement. We have investigated the...

journal_title：Cancer research

authors： Roebuck BD,Longnecker DS,Baumgartner KJ,Thron CD

更新日期：1985-11-01 00:00:00

abstract：:Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the proinflammatory cytokine TNFα in a set of establ...

journal_title：Cancer research

authors： Hatzikirou H,López Alfonso JC,Leschner S,Weiss S,Meyer-Hermann M

更新日期：2017-04-01 00:00:00

abstract：:We have reported previously that the PTEN COOH-terminal 33 amino acids play a role in the maintenance of PTEN protein stability (Tolkacheva and Chan, Oncogene, 19: 680-689, 2000). By site-directed mutagenesis, we identified two threonine residues within this COOH-terminal region at codon 382 and 383 that may be target...

journal_title：Cancer research

authors： Tolkacheva T,Boddapati M,Sanfiz A,Tsuchida K,Kimmelman AC,Chan AM

更新日期：2001-07-01 00:00:00

abstract：:The growth of solid tumors and the formation of metastases are dependent on neoangiogenesis. One of the most important factors in inducing the formation of new blood vessels is the vascular endothelial growth factor (VEGF), which acts specifically on endothelial cells. VEGF is expressed and secreted by almost all soli...

journal_title：Cancer research

authors： Barleon B,Siemeister G,Martiny-Baron G,Weindel K,Herzog C,Marmé D

更新日期：1997-12-01 00:00:00

abstract：:The lethal and bone marrow toxicity and antitumor activity of the cis- and trans-2-hydroxylated metabolites of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) have been correlated with their relative in vitro alkylating and carbamoylating activities. Both the isomers have considerably greater alkylating activity a...

journal_title：Cancer research

authors： Heal JM,Fox PA,Doukas D,Schein PS

更新日期：1978-04-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:Chronic exposure to UV radiation (UVR), especially in the UVA (315-400 nm) and UVB (280-315 nm) spectrum of sunlight, is the major risk factor for the development of nonmelanoma skin cancer. UVR is a complete carcinogen, which both initiates and promotes carcinogenesis. We found that protein kinase C epsilon (PKCepsil...

journal_title：Cancer research

authors： Wheeler DL,Martin KE,Ness KJ,Li Y,Dreckschmidt NE,Wartman M,Ananthaswamy HN,Mitchell DL,Verma AK

更新日期：2004-11-01 00:00:00

abstract：:Several factors which influence the sensitivity of Chinese hamster V79 cells to cyclophosphamide (CY) have been studied in vitro in both suspension and monolayer cultures. Activated CY was obtained from the blood of mice 15 to 30 min after i.p. injection of CY (400 mg/kg). At pH 7.4, hypoxia rendered the cells more se...

journal_title：Cancer research

authors： Begg AC,Shrieve DC,Smith KA,Terry NH

更新日期：1985-08-01 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinoge...

journal_title：Cancer research

authors： Delclos KB,el-Bayoumy K,Casciano DA,Walker RP,Kadlubar FF,Hecht SS,Shivapurkar N,Mandal S,Stoner GD

更新日期：1989-06-01 00:00:00

abstract：:The influence of gangliosides on tumor growth and frequency of metastasis in vivo as well as on growth and motility of neoplastic cells in vitro was tested utilizing human and rodent cell populations. In mice receiving injections of a ganglioside mixture twice daily the tumor volume, the number of spontaneous metastas...

journal_title：Cancer research

authors： Alessandri G,Filippeschi S,Sinibaldi P,Mornet F,Passera P,Spreafico F,Cappa PM,Gullino PM

更新日期：1987-08-15 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone disease. Myeloma cells express the receptor activator of nuclear factor kappaB ligand (RANKL), induce RANKL expression in the bone marrow, and down-regulate express...

journal_title：Cancer research

authors： Heath DJ,Vanderkerken K,Cheng X,Gallagher O,Prideaux M,Murali R,Croucher PI

更新日期：2007-01-01 00:00:00

abstract：:Breast cancers expressing estrogen receptor-alpha (ERalpha) are associated with a favorable biology and are more likely to respond to hormonal therapy. In addition to ERalpha, other pathways of estrogen response have been identified including ERbeta and GPR30, a membrane receptor for estrogen, and the key mechanisms r...

journal_title：Cancer research

authors： Woodfield GW,Horan AD,Chen Y,Weigel RJ

更新日期：2007-09-15 00:00:00

abstract：:Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the pancreas recapitulate the stepwise progression of the human disease. The inflammatory cytokine interleukin (IL)-6 is often expressed by multi...

journal_title：Cancer research

authors： Zhang Y,Yan W,Collins MA,Bednar F,Rakshit S,Zetter BR,Stanger BZ,Chung I,Rhim AD,di Magliano MP

更新日期：2013-10-15 00:00:00

abstract：:Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene...

journal_title：Cancer research

authors： Suh N,Glasebrook AL,Palkowitz AD,Bryant HU,Burris LL,Starling JJ,Pearce HL,Williams C,Peer C,Wang Y,Sporn MB

更新日期：2001-12-01 00:00:00

abstract：:Exposure of rats to a standard four-cycle feeding regimen of 0.06% 2-acetylaminofluorene (AAF) results in the formation of putatively premalignant hepatic nodules, but the types and magnitude of DNA adducts formed in these nodules has not been previously examined. By using a sensitive 32P-adduct assay (R. C. Gupta, Ca...

journal_title：Cancer research

authors： Gupta RC,Earley K,Becker FF

更新日期：1988-09-15 00:00:00

abstract：:Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP is expressed at higher levels in a wide variety of solid tumors than in the adjacent nonneoplastic tissues. Patients with...

journal_title：Cancer research

authors： Matsushita S,Nitanda T,Furukawa T,Sumizawa T,Tani A,Nishimoto K,Akiba S,Miyadera K,Fukushima M,Yamada Y,Yoshida H,Kanzaki T,Akiyama S

更新日期：1999-04-15 00:00:00

abstract：:In November 1974, in response to a mandate in the revised National Cancer Act of 1974, a plan was introduced for the formation of a Diet, Nutrition, and Cancer Program. Dr. Frank J. Rauscher, Director of the National Cancer Institute, selected a group of scientists who defined the goals of the program and recommended ...

journal_title：Cancer research

authors： Gori GB

更新日期：1975-11-01 00:00:00

abstract：:Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. However, the contribution of proline metabolism to tumorigenesis in hypoxic microenvironments has not...

journal_title：Cancer research

authors： Liu W,Glunde K,Bhujwalla ZM,Raman V,Sharma A,Phang JM

更新日期：2012-07-15 00:00:00

abstract：:Human breast epithelial cells cultured from milk have been transformed with SV40. Indirect immunofluorescence tests using monoclonal antibodies show that cells from clones grown in soft agar have SV40 large T-antigen in their nuclei and epithelia-specific tonofilament antigens on their intermediate filaments. In prima...

journal_title：Cancer research

authors： Chang SE,Keen J,Lane EB,Taylor-Papadimitriou J

更新日期：1982-05-01 00:00:00

abstract：:Fischer X Copenhagen rats bearing Dunning R3327-AT tumors were treated with hematoporphyrin derivative and red light (630 nm from an argon-driven dye laser) alone or in combination with the hypoxic cell radiosensitizer, misonidazole (MISO). In vitro studies had suggested that hypoxia might significantly decrease the c...

journal_title：Cancer research

authors： Gonzalez S,Arnfield MR,Meeker BE,Tulip J,Lakey WH,Chapman JD,McPhee MS

更新日期：1986-06-01 00:00:00