Carcinogen-induced lesions in the rat pancreas: effects of varying levels of essential fatty acid.

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like cells have been assumed to have unique properties, including the capability of se...

journal_title：Cancer research

authors： Tamiro F,Weng AP,Giambra V

更新日期：2021-01-07 00:00:00

abstract：:DNA damage response (DDR) pathways maintain genomic stability. A 657del5 mutation of NBS1, a key DDR component, causing the rare cancer-predisposing Nijmegen breakage syndrome has been reported nearly exclusively in Slavic populations. In this study, we describe the first identification in a Japanese population of an ...

journal_title：Cancer research

authors： Ebi H,Matsuo K,Sugito N,Suzuki M,Osada H,Tajima K,Ueda R,Takahashi T

更新日期：2007-12-01 00:00:00

abstract：:Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine re...

journal_title：Cancer research

authors： Gattenlöhner S,Marx A,Markfort B,Pscherer S,Landmeier S,Juergens H,Müller-Hermelink HK,Matthews I,Beeson D,Vincent A,Rossig C

更新日期：2006-01-01 00:00:00

abstract：:Thirty patients with cisplatin-refractory germ cell tumor were treated with high-dose carboplatin, etoposide, and cyclophosphamide and autologous bone marrow transplantation. The total dose of carboplatin was 1500 mg/m2, etoposide 1200 mg/m2, and cyclophosphamide was increased by increments from 60 to 150 mg/kg. Twent...

journal_title：Cancer research

authors： Motzer RJ,Gulati SC,Tong WP,Menendez-Botet C,Lyn P,Mazumdar M,Vlamis V,Lin S,Bosl GJ

更新日期：1993-08-15 00:00:00

abstract：:Genomic aberrations on chromosome 8 are common in colon cancer, and are associated with lymph node and distant metastases as well as with disease susceptibility. This prompted us to generate a high-resolution map of genomic imbalances of chromosome 8 in 51 primary colon carcinomas using a custom-designed genomic array...

journal_title：Cancer research

authors： Camps J,Grade M,Nguyen QT,Hörmann P,Becker S,Hummon AB,Rodriguez V,Chandrasekharappa S,Chen Y,Difilippantonio MJ,Becker H,Ghadimi BM,Ried T

更新日期：2008-03-01 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:Major surgery impairs the cellular immune response. We have therefore studied the immunological effects of low-dose recombinant interleukin 2 given to patients undergoing surgery for colorectal cancer to determine whether this agent has potential in perioperative adjuvant immunotherapy. Patients were randomly allocate...

journal_title：Cancer research

authors： Nichols PH,Ramsden CW,Ward U,Sedman PC,Primrose JN

更新日期：1992-10-15 00:00:00

abstract：:Merbarone is a catalytic inhibitor of DNA topoisomerase (topo) II that does not stabilize DNA-topo II cleavable complexes. Although the cytotoxicity of and resistance to complex-stabilizing topo II inhibitors, such as etoposide, is thought to be mediated through stabilization of these complexes, the mechanisms of cyto...

journal_title：Cancer research

authors： Kusumoto H,Rodgers QE,Boege F,Raimondi SC,Beck WT

更新日期：1996-06-01 00:00:00

abstract：:The origin of cancer chemotherapy can be traced to the wartime discovery of the lymphotoxic action of nitrogen mustards. These and other bifunctional agents were later found to produce various types of DNA cross-links, and some of these agents continue to be mainstays of current therapy. The cellular pharmacology of t...

journal_title：Cancer research

authors： Kohn KW

更新日期：1996-12-15 00:00:00

abstract：:Control rats or rats bearing Morris hepatoma 5123C (intact), 5123C (adrenalectomized), 7794A, 7800, 8999, 9121, or 9618A were fed a purified diet either deficient or adequate for vitamin B6. The concentration of pyridoxal phosphate in the plasma, host livers, and hepatomas was determined, as well as the in vitro rate ...

journal_title：Cancer research

authors： Reynolds RD,Morris HP

更新日期：1979-08-01 00:00:00

abstract：:The antimetastatic activity of Nocardia rubra cell wall skeleton (N-CWS) with or without cyclophosphamide was examined in an experimental model of pulmonary metastasis induced by Lewis lung carcinoma in C57BL/6 mice. Lewis lung carcinoma cells were implanted into the footpads of mice, and the implanted tumors were rem...

journal_title：Cancer research

authors： Kagawa K,Yamashita T,Tsubura E,Yamamura Y

更新日期：1984-02-01 00:00:00

abstract：:We have investigated the ability of several drugs commonly used in the treatment of human cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute leukemia, lymphoma, breast cancer, and prostate cancer. The results of this analysis indicate that drugs affecting the integrity of micro...

journal_title：Cancer research

authors： Haldar S,Basu A,Croce CM

更新日期：1997-01-15 00:00:00

abstract：:Erythrocytes containing micronuclei serve as an indicator of genotoxic exposure in splenectomized individuals. Micronucleated erythrocytes, derived from cytogenetically damaged RBC precursors, are not selectively removed from peripheral blood in individuals who lack splenic function. The relationship between micronucl...

journal_title：Cancer research

authors： Smith DF,MacGregor JT,Hiatt RA,Hooper NK,Wehr CM,Peters B,Goldman LR,Yuan LA,Smith PA,Becker CE

更新日期：1990-08-15 00:00:00

abstract：:Protein kinase C delta (PKCdelta), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is among the novel PKCs (delta, epsilon, and eta) expressed in mouse epidermis. We reported that FVB/N transgenic mice that overexpress ( approximately 8-fold) PKCdelta protein in basal epidermal cells and cells of...

journal_title：Cancer research

authors： Aziz MH,Wheeler DL,Bhamb B,Verma AK

更新日期：2006-01-15 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:Hollow organs lined by columnar epithelial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen. These heterogeneously O-glycosylated molecules are known to aberrantly enter the bloodstream in the setting of epithelial carcinomas and possibly during injury or inflammation. We have r...

journal_title：Cancer research

authors： Wahrenbrock MG,Varki A

更新日期：2006-02-15 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) regulates growth of various cells, and inactivation of the TGF-beta signaling pathway contributes to tumor progression. Smad2 is phosphorylated and activated by TGF-beta, resulting in the antiproliferative effects of TGF-beta signaling. Smurf2 (Smad ubiquitination regulatory ...

journal_title：Cancer research

authors： Fukuchi M,Fukai Y,Masuda N,Miyazaki T,Nakajima M,Sohda M,Manda R,Tsukada K,Kato H,Kuwano H

更新日期：2002-12-15 00:00:00

abstract：:Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms responsible for tumor regression occurring in these patients remain unclear. Preclinical insight into these mechanisms is limited by a paucity of orthotopic animal m...

journal_title：Cancer research

authors： Gruys ME,Back TC,Subleski J,Wiltrout TA,Lee JK,Schmidt L,Watanabe M,Stanyon R,Ward JM,Wigginton JM,Wiltrout RH

更新日期：2001-08-15 00:00:00

abstract：:Previous studies have shown that treatment of rats with gonadotropin-releasing hormone (GnRH) analogues or steroids either before exposure to procarbazine or radiation or after irradiation enhances subsequent levels of spermatogenesis. We demonstrate here that giving a GnRH agonist after procarbazine injection also en...

journal_title：Cancer research

authors： Meistrich ML,Wilson G,Huhtaniemi I

更新日期：1999-08-01 00:00:00

abstract：:We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LK...

journal_title：Cancer research

authors： Upadhyay S,Liu C,Chatterjee A,Hoque MO,Kim MS,Engles J,Westra W,Trink B,Ratovitski E,Sidransky D

更新日期：2006-08-15 00:00:00

abstract：:The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alte...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Shiraishi T,Alder H,Mimori K,Mori M,Croce CM

更新日期：2002-04-15 00:00:00

abstract：:The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b(+)CD11c(+)Ly6C(high)Ly6G(-)MHCII(+) dendritic cell-like an...

journal_title：Cancer research

authors： Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G

更新日期：2014-01-15 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the United States. The deoxynucleoside analogue gemcitabine is among the most effective therapies to treat PDAC, however, nearly all patients treated with gemcitabine either fail to respond or rapidly develop resistance. One hallmark of PDA...

journal_title：Cancer research

authors： Dalin S,Sullivan MR,Lau AN,Grauman-Boss B,Mueller HS,Kreidl E,Fenoglio S,Luengo A,Lees JA,Vander Heiden MG,Lauffenburger DA,Hemann MT

更新日期：2019-11-15 00:00:00

abstract：:This study investigates the effect of variations in dietary vitamin E on the incidence of dimethylhydrazine-induced colonic tumors in mice. Two groups of 65 LACA mice were given 28 weekly s.c. injections of dimethylhydrazine. The only difference in the management of the two groups was the dietary content of vitamin E;...

journal_title：Cancer research

authors： Cook MG,McNamara P

更新日期：1980-04-01 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases th...

journal_title：Cancer research

authors： Aldaz CM,Gollahon LS,Chen A

更新日期：1993-11-15 00:00:00

abstract：:Treatment of male rats with the anticancer drug cisplatin leads to feminization of the profile of cytochrome P-450 and other microsomal enzymes involved in steroid hormone and drug metabolism (G.A. LeBlanc, and D.J. Waxman, J. Biol. Chem., 263: 15732-15739, 1988). The present study uses the rat model to evaluate the d...

journal_title：Cancer research

authors： LeBlanc GA,Sundseth SS,Weber GF,Waxman DJ

更新日期：1992-02-01 00:00:00