Bcl2 is the guardian of microtubule integrity.

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:We have previously shown that N-cadherin expression is associated with tumor invasion, and that some cancer cells respond to specific extracellular matrix molecules by up-regulating N-cadherin. Pancreatic cancer is characterized by excessive deposition of type I collagen. Here, we show that human pancreatic cancer cel...

journal_title：Cancer research

authors： Shintani Y,Hollingsworth MA,Wheelock MJ,Johnson KR

更新日期：2006-12-15 00:00:00

abstract：:In a preceding paper (D. B. Alexander et al., Cancer Res., 53: 1808-1815, 1993), we demonstrated that the in vitro glucocorticoid inhibition of Con8 mammary tumor cell growth is accompanied by the disruption of a transforming growth factor alpha (TGF-alpha) autocrine loop. This growth suppression response functions in...

journal_title：Cancer research

authors： Goya L,Alexander DB,Webster MK,Kern FG,Guzman RC,Nandi S,Firestone GL

更新日期：1993-04-15 00:00:00

abstract：:Nerve growth factor-like substance(s) were identified in both conditioned media of a human prostatic tumor epithelial cell line (TSU-pr1) and a human prostatic stromal cell line (HPS) by Western blot analysis and bioassay of neurite outgrowth of PC12 cells. Nerve growth factor-beta (NGF) immunofluorescence was also lo...

journal_title：Cancer research

authors： Djakiew D,Delsite R,Pflug B,Wrathall J,Lynch JH,Onoda M

更新日期：1991-06-15 00:00:00

abstract：:The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, bu...

journal_title：Cancer research

authors： Katagiri YU,Sleeman J,Fujii H,Herrlich P,Hotta H,Tanaka K,Chikuma S,Yagita H,Okumura K,Murakami M,Saiki I,Chambers AF,Uede T

更新日期：1999-01-01 00:00:00

abstract：:Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach. It has been implicated in tumor growth, sensitivity to standard chemotherapy, prognosis of patients, and disease-free survival. Although the clinical use of tra...

journal_title：Cancer research

authors： Jani JP,Finn RS,Campbell M,Coleman KG,Connell RD,Currier N,Emerson EO,Floyd E,Harriman S,Kath JC,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Ralston S,Rossi AM,Steyn SJ,Wagner L,Winter SM,Bhattacharya SK

更新日期：2007-10-15 00:00:00

abstract：:A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. In lung SCC, one of the most frequently altered receptor tyrosine kinase families is the fibroblast...

journal_title：Cancer research

authors： Liao RG,Jung J,Tchaicha J,Wilkerson MD,Sivachenko A,Beauchamp EM,Liu Q,Pugh TJ,Pedamallu CS,Hayes DN,Gray NS,Getz G,Wong KK,Haddad RI,Meyerson M,Hammerman PS

更新日期：2013-08-15 00:00:00

abstract：:Experimental studies using murine tumor models have demonstrated that potent systemic immunity can be generated using tumor vaccines engineered by gene transfer to secrete certain cytokines. The underlying physiological principle behind these strategies involves the sustained release of high doses of cytokine at the s...

journal_title：Cancer research

authors： Golumbek PT,Azhari R,Jaffee EM,Levitsky HI,Lazenby A,Leong K,Pardoll DM

更新日期：1993-12-15 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in 235 specimens of lung cancer show the tightest inverse association between the histological grading in the most aggressive tum...

journal_title：Cancer research

authors： Claudio PP,Howard CM,Pacilio C,Cinti C,Romano G,Minimo C,Maraldi NM,Minna JD,Gelbert L,Leoncini L,Tosi GM,Hicheli P,Caputi M,Giordano GG,Giordano A

更新日期：2000-01-15 00:00:00

abstract：:The mechanisms by which estrogens and antiestrogens modulate breast cancer growth have not been totally defined. We have examined the cell cycle kinetic effects of estrogens and antiestrogens in cultured human breast cancer cell lines. In a previous study, we showed that tamoxifen induces a transition delay in early t...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Estrada P

更新日期：1984-04-01 00:00:00

abstract：:In order to improve local control of tumors over that achievable with local hyperthermia and radiation, we are testing the use of systemic cis-diamminedichloroplatinum(II) (CDDP) in conjunction with the other two modalities. In the FSaIIC fibrosarcoma, growth delay experiments indicated that the use of any two modalit...

journal_title：Cancer research

authors： Herman TS,Teicher BA

更新日期：1988-05-15 00:00:00

abstract：:The candidate tumor suppressor gene RASSF1A is inactivated in many types of adult and childhood cancers. However, the mechanisms by which RASSF1A exerts its tumor suppressive functions have yet to be elucidated. To this end, we performed a yeast two-hybrid screen to identify novel RASSF1A-interacting proteins in a hum...

journal_title：Cancer research

authors： Dallol A,Agathanggelou A,Fenton SL,Ahmed-Choudhury J,Hesson L,Vos MD,Clark GJ,Downward J,Maher ER,Latif F

更新日期：2004-06-15 00:00:00

abstract：:Recent in vitro studies of the epidermal growth factor receptor (EGFR) family have revealed complex signaling interactions involving the production of ligand-mediated heterodimers synergistic for the transformation of cells in vitro. In a series of 70 patients with childhood medulloblastoma, we have used immunohistoch...

journal_title：Cancer research

authors： Gilbertson RJ,Perry RH,Kelly PJ,Pearson AD,Lunec J

更新日期：1997-08-01 00:00:00

abstract：:Both Src kinase and membrane type 1 matrix metalloproteinase (MT1-MMP) play critical roles in cancer invasion and metastasis. It is not clear, however, how the spatiotemporal activation of these two critical enzymes is coordinated in response to an oncogenic epithelial growth factor (EGF) stimulation. Here, we have vi...

journal_title：Cancer research

authors： Ouyang M,Huang H,Shaner NC,Remacle AG,Shiryaev SA,Strongin AY,Tsien RY,Wang Y

更新日期：2010-03-15 00:00:00

abstract：:A large proportion of human tumor-derived cell lines and primary tumor cells show methionine-dependent growth. This phenomenon refers to the ability of cells to grow in media containing methionine and the inability of cells to grow in media supplemented with methionine's precursor, homocysteine (Hcy). Methionine can b...

journal_title：Cancer research

authors： Tang B,Li YN,Kruger WD

更新日期：2000-10-01 00:00:00

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A...

journal_title：Cancer research

authors： Fukumoto T,Fatkhutdinov N,Zundell JA,Tcyganov EN,Nacarelli T,Karakashev S,Wu S,Liu Q,Gabrilovich DI,Zhang R

更新日期：2019-11-01 00:00:00

abstract：:A cell line (NCE-G28) was established from the biopsy material of a human gliosarcoma of low histological differentiation. The initial cultures showed a mixed population of cells which in later stages became more uniform due to loss of slower growing constituents. The cells have been growing steadily for 20 months. A ...

journal_title：Cancer research

authors： Westphal M,Haensel M,Mueller D,Laas R,Kunzmann R,Rohde E,Koenig A,Hoelzel F,Herrmann HD

更新日期：1988-02-01 00:00:00

abstract：:We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human cancer cells and tumors. Survivin inhibits caspase-9, blocks apoptosis, and is associated with resistance to chemotherapy and radiation. Survivin is a client p...

journal_title：Cancer research

authors： Ferrario A,Rucker N,Wong S,Luna M,Gomer CJ

更新日期：2007-05-15 00:00:00

abstract：:The homologous proteins p68 and p72 are members of the DEAD box family of RNA helicases. Here, we show that expression of both of these helicases strongly increases during the polyp-->adenoma-->adenocarcinoma transition in the colon. Furthermore, p68 and p72 form complexes with beta-catenin and promote the ability of ...

journal_title：Cancer research

authors： Shin S,Rossow KL,Grande JP,Janknecht R

更新日期：2007-08-15 00:00:00

abstract：:Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively expressed in the tumor cells and a nontoxic prodrug is then given, whi...

journal_title：Cancer research

authors： Schepelmann S,Hallenbeck P,Ogilvie LM,Hedley D,Friedlos F,Martin J,Scanlon I,Hay C,Hawkins LK,Marais R,Springer CJ

更新日期：2005-06-15 00:00:00

abstract：:Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

journal_title：Cancer research

authors： Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

更新日期：1995-11-01 00:00:00

abstract：:Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multipl...

journal_title：Cancer research

authors： Jiang Y,Pan Y,Rhea PR,Tan L,Gagea M,Cohen L,Fischer SM,Yang P

更新日期：2016-01-01 00:00:00

abstract：:Oncogenic transformation has been induced in vitro in the C3H/10T1/2 clone 8 line of mouse cells by exposure to 5-fluoro-2'-deoxyuridine (FUdR) or 5-fluorouracil. This transformation is both dose and time dependent and can be markedly decreased by simultaneous exposure of the cells to thymidine. The transformation ind...

journal_title：Cancer research

authors： Jones PA,Benedict WF,Baker MS,Mondal S,Rapp U,Heidelberger C

更新日期：1976-01-01 00:00:00

abstract：:Several responses of 10T 1/2 cells and of cells from strains transformed by X-irradiation or by methylcholanthrene exposure were examined. Malignant potential, as determined by the ability of the cells to initiate tumors in syngeneic hosts, either normal or rendered immunodeficient, varied by a factor of 10(6). The gr...

journal_title：Cancer research

authors： Hahn GM

更新日期：1980-10-01 00:00:00

abstract：:Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success la...

journal_title：Cancer research

authors： Siddiqui IA,Adhami VM,Bharali DJ,Hafeez BB,Asim M,Khwaja SI,Ahmad N,Cui H,Mousa SA,Mukhtar H

更新日期：2009-03-01 00:00:00

abstract：:The interaction of dietary fat and the thymus in the induction of mammary tumors by dimethylbenz(a)anthracene has been examined in female Sprague-Dawley rats. In these experiments, rats fed diets of 0.5% (low fat), 5% (normal fat), or 20% (high fat) corn oil from weaning (21 days of age) were thymectomized or sham thy...

journal_title：Cancer research

authors： Wagner DA,Naylor PH,Kim U,Shea W,Ip C,Ip MM

更新日期：1982-04-01 00:00:00

abstract：:Athymic mice infected with pinworms or carrying human tumor xenografts frequently develop a lymphoproliferative disorder which eventually leads to lymphoma. By immunofluorescent analysis of involved tissues, the lymphomas appear to be mixtures of null cells, B-cells, and T-cells. When each lymphoma is established in t...

journal_title：Cancer research

authors： Baird SM,Beattie GM,Lannom RA,Lipsick JS,Jensen FC,Kaplan NO

更新日期：1982-01-01 00:00:00

abstract：:Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

journal_title：Cancer research

authors： Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

更新日期：2002-11-15 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00