Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:It is anticipated that this report will serve as a nucleus for stimulating meaningful studies of the biology of prostate cancer. Such studies will be essential for the control and ultimately the prevention of prostate cancer. The present focus was arrived at by consensus of an expert panel on prostate cancer. It is no...

journal_title：Cancer research

authors： Chiarodo A

更新日期：1991-05-01 00:00:00

abstract：:MUC1 is a heterodimeric transmembrane glycoprotein that is overexpressed and aberrantly glycosylated in ductal adenocarcinomas. Differential phosphorylation of the MUC1 cytoplasmic tail (MUC1CT) has been associated with signaling events that influence the proliferation and metastasis of cancer cells. We identified a n...

journal_title：Cancer research

authors： Singh PK,Wen Y,Swanson BJ,Shanmugam K,Kazlauskas A,Cerny RL,Gendler SJ,Hollingsworth MA

更新日期：2007-06-01 00:00:00

abstract：:RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, bladder, breast, ovary, uterus, and prostate. Efficient targeting and therapy by radiolabeled RS7 has been demonstrated previously in anima...

journal_title：Cancer research

authors： Shih LB,Xuan H,Aninipot R,Stein R,Goldenberg DM

更新日期：1995-12-01 00:00:00

abstract：:Mouse bladder tumor (MBT-2), derived from a carcinogen-induced transitional cell carcinoma of the bladder, has proven a useful model for study of pathogenesis and prediction of cytotoxic drug sensitivity of human bladder carcinoma. To define optimal conditions for activity of the potent interferon inducer polyriboinos...

journal_title：Cancer research

authors： Borden EC,Sidky YA,Groveman DS,Bryan GT

更新日期：1985-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) are effective in suppressing the formation of colorectal tumors. However, the mechanisms underlying the antineoplastic effects of NSAIDs remain unclear. The effects of NSAIDs are incomplete, and resistance to NSAIDs is often developed. Growing evidence has indicated that th...

journal_title：Cancer research

authors： Bank A,Wang P,Du C,Yu J,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is activated in the majority of melanomas, and its activity is essential for cell survival. In this report, we examined the effects of a novel raf inhibitor BAY 43-9006 on melanoma cell viability and intracellular signaling and found that it induces apoptosis through a caspase-i...

journal_title：Cancer research

authors： Panka DJ,Wang W,Atkins MB,Mier JW

更新日期：2006-02-01 00:00:00

abstract：:The lymphoid tissue in the omentum, at the so-called milky spots, is known as an initial place for disseminated cancer cells to develop into solid tumors. In the present study, i.p. macrophages significantly took up oligomannose-coated liposomes (OMLs) that were injected into the peritoneal cavity, and then gradually ...

journal_title：Cancer research

authors： Ikehara Y,Niwa T,Biao L,Ikehara SK,Ohashi N,Kobayashi T,Shimizu Y,Kojima N,Nakanishi H

更新日期：2006-09-01 00:00:00

abstract：:Aberrant promoter hypermethylation and associated gene silencing are epigenetic hallmarks of tumorigenesis. It has been suggested that aberrant DNA methylation can affect the sensitivity of cancers to antineoplastic agents by altering expression of genes critical to drug response. To study this issue, we used bisulfit...

journal_title：Cancer research

authors： Shen L,Kondo Y,Ahmed S,Boumber Y,Konishi K,Guo Y,Chen X,Vilaythong JN,Issa JP

更新日期：2007-12-01 00:00:00

abstract：:Patients receiving cytotoxic drugs are at an increased risk of bacterial infection. Drug-induced leukopenia may be responsible for depression of host defenses; however, there is little information concerning the qualitative effects, if any, of cytotoxic agents on granulocyte antibacterial activity. Since methotrexate ...

journal_title：Cancer research

authors： Hyams JS,Donaldson MH,Metcalf JA,Root RK

更新日期：1978-03-01 00:00:00

abstract：:Bone marrow cells freshly aspirated from the 10 consecutive untreated adult patients with acute nonlymphocytic leukemia were cultured by 2 different methods: the conventional agar culture method for myeloid colony formation and its modification by daily feeding with culture medium. In 5 patients, colonies grew in much...

journal_title：Cancer research

authors： Park CH,Savin MA,Hoogstraten B,Amare M,Hathaway P

更新日期：1977-12-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region o...

journal_title：Cancer research

authors： Numata S,Claudio PP,Dean C,Giordano A,Croce CM

更新日期：1999-08-01 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:Melanoma differentiation associated gene-7/interleukin-24 (Mda-7/IL-24), a novel member of the IL-10 family of cytokines, uniquely displays cancer-specific apoptosis-inducing activity. Positive results in ongoing phase I/II clinical trials have strengthened the possibility of its utilization as a cancer gene therapeut...

journal_title：Cancer research

authors： Sauane M,Lebedeva IV,Su ZZ,Choo HT,Randolph A,Valerie K,Dent P,Gopalkrishnan RV,Fisher PB

更新日期：2004-05-01 00:00:00

abstract：:Exposure of Chinese hamster ovary cells to the enzyme inhibitors methylglyoxal bis(guanylhydrazone and alpha-difluoromethylornithine (DFMO) results in increased sensitivity to hyperthermia. While methylglyoxal bis(guanylhydrazone) demonstrates pronounced cytotoxicity at moderate extracellular concentrations, DFMO is t...

journal_title：Cancer research

authors： Fuller DJ,Gerner EW

更新日期：1982-12-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:Our goal is to develop peptide vaccines that stimulate tumor antigen-specific T-cell responses against frequently found cancers. Previous work has shown that to generate effective T-cell responses, peptides have to be administered in combination with strong adjuvants such as Toll-like receptor agonists. However, most ...

journal_title：Cancer research

authors： Nava-Parada P,Forni G,Knutson KL,Pease LR,Celis E

更新日期：2007-02-01 00:00:00

abstract：:The role of hereditary polymorphisms of the arylamine N-acetyltransferase 1 (NAT1) gene in the etiology of urinary bladder cancer is controversial. NAT1 is expressed in the urothelium and may O-acetylate hydroxyl amines, particularly in subjects with low NAT2 activity. Thus, NAT1 polymorphisms may affect the individua...

journal_title：Cancer research

authors： Cascorbi I,Roots I,Brockmöller J

更新日期：2001-07-01 00:00:00

abstract：:Anti-VEGF therapy prolongs recurrence-free survival in patients with glioblastoma but does not improve overall survival. To address this discrepancy, we investigated immunologic resistance mechanisms to anti-VEGF therapy in glioma models. A screening of immune-associated alterations in tumors after anti-VEGF treatment...

journal_title：Cancer research

authors： Long Y,Tao H,Karachi A,Grippin AJ,Jin L,Chang YE,Zhang W,Dyson KA,Hou AY,Na M,Deleyrolle LP,Sayour EJ,Rahman M,Mitchell DA,Lin Z,Huang J

更新日期：2020-02-01 00:00:00

abstract：:Loss of imprinting (LOI) of the insulin-like growth factor II (IGFII) gene is a frequent phenomenon in colorectal tumor tissues. Previous reports indicated that subjects with colorectal neoplasias show LOI of IGFII in circulating lymphocytes. Furthermore, LOI of IGFII is strongly related to the methylation of a differ...

journal_title：Cancer research

authors： Kaaks R,Stattin P,Villar S,Poetsch AR,Dossus L,Nieters A,Riboli E,Palmqvist R,Hallmans G,Plass C,Friesen MD

更新日期：2009-07-01 00:00:00

abstract：:Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, in...

journal_title：Cancer research

authors： Bussard KM,Siracusa LD

更新日期：2017-11-15 00:00:00

abstract：:Successive B16 melanoma tumor lines were selected for their ability to form pulmonary tumor nodules. This was accomplished by injecting tumor cells i.v. into syngeneic C57BL/6 mice and 2 to 3 weeks later collecting the secondary tumor growths and placing them into tissue culture. These tumor cells were then injected i...

journal_title：Cancer research

authors： Fidler IJ

更新日期：1975-01-01 00:00:00

abstract：:High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins t...

journal_title：Cancer research

authors： Gao Q,Kumar A,Singh L,Huibregtse JM,Beaudenon S,Srinivasan S,Wazer DE,Band H,Band V

更新日期：2002-06-01 00:00:00

abstract：:Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclita...

journal_title：Cancer research

authors： Shi J,Zhou Y,Huang HC,Mitchison TJ

更新日期：2011-07-01 00:00:00

abstract：:Genes encoding the four principal polypeptide domains (N, A1-B1, A2-B2, and A3-B3) of carcinoembryonic antigen (CEA) were synthesized and expressed in Escherichia coli as fusion products with bacterial CMP-KDO synthetase (CKS). The four synthetic fusion proteins were purified in high yield and used as targets in Weste...

journal_title：Cancer research

authors： Hass GM,Bolling TJ,Kinders RJ,Henslee JG,Mandecki W,Dorwin SA,Shively JE

更新日期：1991-04-01 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:Inbred rodent strains with differing sensitivity to experimental tumor induction provide model systems for the detection of genes that either are responsible for cancer predisposition or modify the process of carcinogenesis. Rats of the inbred BD strains differ in their susceptibility to the induction of neural tumors...

journal_title：Cancer research

authors： Kindler-Röhrborn A,Kölsch BU,Fischer C,Held S,Rajewsky MF

更新日期：1999-03-01 00:00:00

abstract：:Squamous cell carcinoma of the head and neck (SCCHN) metastasizes predictably to cervical lymph nodes, with low rates of distant metastases. Tumor cells can express various receptors that facilitate such metastatic spread to lymph nodes and other nonlymphoid organs. Chemokine receptors (CCR), normally expressed on lym...

journal_title：Cancer research

authors： Wang J,Xi L,Hunt JL,Gooding W,Whiteside TL,Chen Z,Godfrey TE,Ferris RL

更新日期：2004-03-01 00:00:00

abstract：:The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect was observed when BLM (5 mg/kg/day) was administered i.p. for 5 days from the eighth day after tumor inoculation (Day 8 to D...

journal_title：Cancer research

authors： Morikawa K,Hosokawa M,Hamada J,Sugawara M,Kobayashi H

更新日期：1985-04-01 00:00:00