Human lymphoblastoid cell lines as effector cells in mitogen-dependent and antibody-dependent cell-mediated lysis.

abstract：:In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances...

journal_title：Cancer research

authors： Steen RG,Tamargo RJ,McGovern KA,Rajan SS,Brem H,Wehrle JP,Glickson JD

更新日期：1988-02-01 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is found at low levels on nontransformed adult breast epithelial cells but is frequently overexpressed on aggressive breast cancer cells. Recent studies have documented an inverse relationship between EphA2 and estrogen receptor expression in breast cancer cell lines. In our present ...

journal_title：Cancer research

authors： Lu M,Miller KD,Gokmen-Polar Y,Jeng MH,Kinch MS

更新日期：2003-06-15 00:00:00

abstract：:L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into...

journal_title：Cancer research

authors： Edelstein MB,Heilbrun LK

更新日期：1988-03-15 00:00:00

abstract：:Significant changes in aldehyde dehydrogenase (ALDH) activity occur during chemically induced rat hepatocarcinogenesis. We have developed a procedure for the histochemical localization of hepatic ALDH which has proven extremely useful as an additional probe for studying changes in this enzyme during hepatocarcinogenes...

journal_title：Cancer research

authors： Lindahl R,Clark R,Evces S

更新日期：1983-12-01 00:00:00

abstract：:Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technol...

journal_title：Cancer research

authors： Maeda T,Nagano S,Ichise H,Kataoka K,Yamada D,Ogawa S,Koseki H,Kitawaki T,Kadowaki N,Takaori-Kondo A,Masuda K,Kawamoto H

更新日期：2016-12-01 00:00:00

abstract：:Glycolipids of murine lymphoma cell lines with low metastatic (Eb) and high metastatic (ESb) potentials have been investigated. The Eb cell line was characterized by a high quantity of gangliotriaosylceramide (Gg3), gangliotetraosylceramide (Gg4), GM1b, and a new type of disialoganglioside, termed GD1 alpha. In contra...

journal_title：Cancer research

authors： Murayama K,Levery SB,Schirrmacher V,Hakomori S

更新日期：1986-03-01 00:00:00

abstract：:Cell isolation via antibody-targeted magnetic beads is a powerful tool for research and clinical applications, most recently for isolating circulating tumor cells (CTC). Nonetheless fundamental features of the cell-bead interface are still unknown. Here we apply a clinically relevant antibody against the cancer target...

journal_title：Cancer research

authors： Jain J,Veggiani G,Howarth M

更新日期：2013-04-01 00:00:00

abstract：:Recently we have reported synergistic effects between glycine-extended gastrin (G-gly) and amidated gastrin-17 on acid secretion in short-term infusion studies. In the present study, we examined the long-term effect of G-gly on the atrophy-promoting effects of amidated gastrin in the mouse stomach with or without Heli...

journal_title：Cancer research

authors： Cui G,Koh TJ,Chen D,Zhao CM,Takaishi S,Dockray GJ,Varro A,Rogers AB,Fox JG,Wang TC

更新日期：2004-11-15 00:00:00

abstract：:Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitigated and uncertain. Here, we report that PACE4 pre-mRNA undergoes DNA...

journal_title：Cancer research

authors： Couture F,Sabbagh R,Kwiatkowska A,Desjardins R,Guay SP,Bouchard L,Day R

更新日期：2017-12-15 00:00:00

abstract：:Differential display is a valuable tool for the identification of differentially expressed genes in human carcinogenesis and development. The search for differentially expressed genes in gastric cancer and its premalignant lesions may help to define molecular alterations in the gastric mucosa that may precede the deve...

journal_title：Cancer research

authors： Ebert MP,Günther T,Hoffmann J,Yu J,Miehlke S,Schulz HU,Roessner A,Korc M,Malfertheiner P

更新日期：2000-04-01 00:00:00

abstract：:The main objective of the present study was to sequentially analyze growth and morphological characteristics of aberrant crypt foci (ACF) in the rat colon. Sprague-Dawley rats were given a single injection of a carcinogenic dose of 1,2-dimethylhydrazine-HCl and at varying time points ranging from 2 to 57 weeks, groups...

journal_title：Cancer research

authors： McLellan EA,Medline A,Bird RP

更新日期：1991-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:A balanced lipid metabolism is crucial for all cells. Disturbance of this homeostasis by nonphysiological intracellular accumulation of fatty acids can result in apoptosis. This was proven in animal studies and was correlated to some human diseases, like lipotoxic cardiomyopathy. Some metabolic mechanisms of lipo-apop...

journal_title：Cancer research

authors： Pohle T,Brändlein S,Ruoff N,Müller-Hermelink HK,Vollmers HP

更新日期：2004-06-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is currently being used as a target antigen in the radioimmunodetection of cancer. Circulating CEA may adversely affect the outcome of such studies by formation of intravascular immune complexes. The following studies were undertaken to expand our knowledge of the production, secretion, ...

journal_title：Cancer research

authors： Martin KW,Halpern SE

更新日期：1984-12-01 00:00:00

abstract：:The transcription factor activating transcription factor 2 (ATF2) has been shown to be associated with melanocytic oncogenesis and melanoma tumor proliferation in preclinical models. The clinical significance of ATF2 expression is unknown. To determine the prognostic value of ATF2 in melanoma, we evaluated the pattern...

journal_title：Cancer research

authors： Berger AJ,Kluger HM,Li N,Kielhorn E,Halaban R,Ronai Z,Rimm DL

更新日期：2003-12-01 00:00:00

abstract：:For patients with solid tumors, the tolerance of surrounding tissues often limits the dose of radiation that can be delivered. Thus, agents that preferentially increase the cytotoxic effects of radiation toward tumor cells would significantly alter the therapeutic ratio and improve patient survival. Using a high-throu...

journal_title：Cancer research

authors： Lally BE,Geiger GA,Kridel S,Arcury-Quandt AE,Robbins ME,Kock ND,Wheeler K,Peddi P,Georgakilas A,Kao GD,Koumenis C

更新日期：2007-09-15 00:00:00

abstract：:We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits proliferation of cancer cell lines from various organs and tissues at nanomolar concentrations. Its IC(50) value ranges from 4.1 to 50 nmol/L. The...

journal_title：Cancer research

authors： Zhang LH,Wu L,Raymon HK,Chen RS,Corral L,Shirley MA,Narla RK,Gamez J,Muller GW,Stirling DI,Bartlett JB,Schafer PH,Payvandi F

更新日期：2006-01-15 00:00:00

abstract：:We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassocia...

journal_title：Cancer research

authors： Sumi Y,Nagura H,Miyakawa M

更新日期：1990-01-15 00:00:00

abstract：:In a separate study (F. Courjal et al., Cancer Res., 57: 4360-4367, 1997), we have analyzed by Southern blotting the relationship between DNA amplification and clinicopathological features of breast cancer. Six regions of recurrent amplifications were tested (8p12, 8q24, 11q13, 12q13, 17q12, and 20q13), and the result...

journal_title：Cancer research

authors： Courjal F,Theillet C

更新日期：1997-10-01 00:00:00

abstract：:The effects of in vivo administration of a pharmacologically toxic dose of the lipophilic cationic compound, MKT-077, were investigated in selected vital organs of the rat. MKT-077 (15 mg/kg body weight), administered by bolus i.v. injection every day for 5 days, did not detectably influence rat heart and kidney mitoc...

journal_title：Cancer research

authors： Weisberg EL,Koya K,Modica-Napolitano J,Li Y,Chen LB

更新日期：1996-02-01 00:00:00

abstract：:Transduction of malignant cells with toxin genes provides a novel means to promote tumor cell destruction. The efficacy of a toxin gene is dependent on the cell type targeted, the quantity of exogenous protein synthesized, and the mechanisms of growth inhibition and bystander killing. To develop gene therapy for targe...

journal_title：Cancer research

authors： Hoganson DK,Batra RK,Olsen JC,Boucher RC

更新日期：1996-03-15 00:00:00

abstract：:Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the...

journal_title：Cancer research

authors： Li Y,Nichols MA,Shay JW,Xiong Y

更新日期：1994-12-01 00:00:00

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:We investigated the relationship between age-related changes in natural resistance and antitumor effects using a spontaneously hypertensive rat (SHR rat) strain which shows a progressive decline of the number of T-cells and their functions as a result of aging. The growth of a weakly antigenic mammary adenocarcinoma S...

journal_title：Cancer research

authors： Matsuoka T,Takeichi N,Kobayashi H

更新日期：1987-07-01 00:00:00

abstract：:c-myc expression, amplification, and rearrangement were studied in neoplastic hepatic nodules of rats after diethylnitrosamine treatment, in hepatocellular carcinomas induced by N-methyl-N-nitrosourea, and in tumorigenic liver cell lines derived from rat hepatocytes transformed by diethylnitrosamine in vivo. Steady-st...

journal_title：Cancer research

authors： Suchy BK,Sarafoff M,Kerler R,Rabes HM

更新日期：1989-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:Sera from 91 adult acute nonlymphocytic leukemia patients were tested for circulating immune complexes by the C1q binding test. In 42 patients tested prior to the initiation of therapy, C1q binding activity was inversely correlated with leukemic infiltrate of the bone marrow (rs = -0.34, p less than 0.02), but it was ...

journal_title：Cancer research

authors： Crane MM,Rossen RD,McCredie KB,Trujillo JM

更新日期：1984-07-01 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:A large body of clinical, genetic, and biochemical evidence indicates that cyclooxygenase-2 (COX-2), a key enzyme for prostanoid biosynthesis, contributes to the promotion of colorectal cancer. COX-2-derived prostaglandin E2 (PGE2) is the most abundant prostaglandin found in several gastrointestinal malignancies. Alth...

journal_title：Cancer research

authors： Wang D,Buchanan FG,Wang H,Dey SK,DuBois RN

更新日期：2005-03-01 00:00:00