Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.

abstract：:A unique electrophoretic form of lactate dehydrogenase (LDH-Z), formerly observed in a choriocarcinoma cell line (JEG-3) and first-trimester placenta, has been shown to be the same as that produced in hydatidiform mole and term placenta. We have also observed LDH-Z in second-trimester placenta, choriocarcinoma metasta...

journal_title：Cancer research

authors： Siciliano MJ,Bordelon-Riser ME,Freedman RS,Kohler PO

更新日期：1980-02-01 00:00:00

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:In immunodeficient mice antitumor single-chain Fv (scFv) molecules penetrate tumors rapidly and have rapid serum clearance, leading to excellent tumor:normal organ ratios. However, the absolute quantity of scFv retained in the tumor is low due to rapid serum clearance and monovalent scFv binding. We previously demonst...

journal_title：Cancer research

authors： Nielsen UB,Adams GP,Weiner LM,Marks JD

更新日期：2000-11-15 00:00:00

abstract：:Members of the INK4 family of cyclin-dependent kinase (CDK) inhibitors specifically bind and inhibit the G1-specific CDK molecules CDK4 and CDK6. One of the INK4 molecules, p16, is also known as multiple tumor suppressor and has been found to be mutated or deleted in various tumors and cell lines. We have previously i...

journal_title：Cancer research

authors： Noh SJ,Li Y,Xiong Y,Guan KL

更新日期：1999-02-01 00:00:00

abstract：:The effects of retinyl acetate and all-trans-retinoic acid on the growth rate, saturation density, and cytoplasmic underlapping of normal and carcinogen-initiated C3H/1OT1/2 cells were examined. Retinyl acetate (a) decreased the saturation density by as much as 45%, (b) had no effect on the growth rate, (c) reduced cy...

journal_title：Cancer research

authors： Mordan LJ,Bertram JS

更新日期：1983-02-01 00:00:00

abstract：:It has been postulated that the intestinal anaerobes play a role in the etiology of large bowel cancer. This study was designed to characterize and compare the fecal anaerobes of patients with large bowel cancer, patients with nonhereditary large bowel polyps, and healthy control subjects. Although some distributional...

journal_title：Cancer research

authors： Mastromarino AJ,Reddy BS,Wynder EL

更新日期：1978-12-01 00:00:00

abstract：:The basal layer of the epidermis and hair follicles is composed of actively cycling, transit-amplifying cells and quiescent cells including stem cells. To determine which population is the target of carcinogenic chemicals, we treated CD-1 female mice topically with 5-fluorouracil (5-FU), an agent known to kill cycling...

journal_title：Cancer research

authors： Morris RJ,Coulter K,Tryson K,Steinberg SR

更新日期：1997-08-15 00:00:00

abstract：:Retinoic acid inhibits the proliferation of the murine melanoma clone S91-C-2 cells, enhances the glycosylation of specific cell surface sialoglycoproteins, and stimulates sialytransferase activity. Mutant clones, selected from the S91-C-2 cells for resistance to the growth-inhibitory effect of retinoic acid, were use...

journal_title：Cancer research

authors： Lotan R,Lotan D,Meromsky L

更新日期：1984-12-01 00:00:00

abstract：:We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine kinase transmembrane receptor. Analysis of primary testicular germ cell tumors totaling 190 cases revealed 21% of the seminoma subtype with an increased copy num...

journal_title：Cancer research

authors： McIntyre A,Summersgill B,Grygalewicz B,Gillis AJ,Stoop J,van Gurp RJ,Dennis N,Fisher C,Huddart R,Cooper C,Clark J,Oosterhuis JW,Looijenga LH,Shipley J

更新日期：2005-09-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to the clinical imaging abnormality. Hypoxia, a hallmark of aggressive tumor behavior often noted in GBMs, has been associated with resistance to t...

journal_title：Cancer research

authors： Szeto MD,Chakraborty G,Hadley J,Rockne R,Muzi M,Alvord EC Jr,Krohn KA,Spence AM,Swanson KR

更新日期：2009-05-15 00:00:00

abstract：:NGR-TNF is a derivative of TNF-α that targets tumor blood vessels and enhances penetration of chemotherapeutic drugs. Because of this property, NGR-TNF is being tested in combination with chemotherapy in various phase II and III clinical trials. Here we report that chromogranin A (CgA), a protein present in variable a...

journal_title：Cancer research

authors： Dondossola E,Gasparri AM,Colombo B,Sacchi A,Curnis F,Corti A

更新日期：2011-09-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:The human ether-a-go-go-related gene (herg) encodes a K+ current (IHERG) that plays a fundamental role in heart excitability by regulating the action potential repolarization (IKr); mutations of this gene are responsible for the chromosome 7-linked long QT syndrome (LQT2). In this report, we show that in a variety (n ...

journal_title：Cancer research

authors： Bianchi L,Wible B,Arcangeli A,Taglialatela M,Morra F,Castaldo P,Crociani O,Rosati B,Faravelli L,Olivotto M,Wanke E

更新日期：1998-02-15 00:00:00

abstract：:S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of radiation-induced leg contractures in C3Hf/Kam mice whose legs were exposed to single doses of gamma-radiation. The radiation doses ranged from 3300 to 6200 rads delivered to the right hind thighs ...

journal_title：Cancer research

authors： Hunter N,Milas L

更新日期：1983-04-01 00:00:00

abstract：:Mutational synergism was examined in Chinese hamster V79 cells exposed to methyl methanesulfonate followed by N-acetoxy-2-acetylaminofluorene (AcAAF) at different time intervals. Treatment with 500 micron methyl methanesulfonate resulted in 95% survival of cloning ability and induced approximately 4 azaguanine-resista...

journal_title：Cancer research

authors： Myhr BC,DiPaolo JA

更新日期：1978-08-01 00:00:00

abstract：:Interleukin 2 (IL-2) is a secreted glycoprotein which acts as an activation and proliferative signal for lymphocytes expressing membrane-bound glycoprotein IL-2 receptors. We have recently established that swainsonine (SW), an inhibitor of mannosidase II during N-linked glycoprotein processing, augmented mitogen-induc...

journal_title：Cancer research

authors： Bowlin TL,McKown BJ,Kang MS,Sunkara PS

更新日期：1989-08-01 00:00:00

abstract：:Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-beta can act as a drug sensiti...

journal_title：Cancer research

authors： Natsume A,Ishii D,Wakabayashi T,Tsuno T,Hatano H,Mizuno M,Yoshida J

更新日期：2005-09-01 00:00:00

abstract：:The biosynthesis, structure, and topology of a melanoma-associated antigen, previously defined with the monoclonal antibody NKI/C-3 was studied. A polyclonal rabbit antiserum was raised against the antigen with a broader reactivity than the previously used monoclonal antibody NKI/C-3. The antigen was shown to consist ...

journal_title：Cancer research

authors： Gruters RA,Calafat J,Vennegoor CJ,Jansen H,Ploegh HL

更新日期：1989-01-15 00:00:00

abstract：:To determine the role of the transcription factor signal transducer and activator of transcription (STAT) 1 on endothelial cell function, human umbilical vein endothelial cells (HUVEC) were treated with IFN-gamma, a potent activator of STAT1. IFN-gamma inhibited cell growth and tube formation of HUVECs. Although the p...

journal_title：Cancer research

authors： Battle TE,Lynch RA,Frank DA

更新日期：2006-04-01 00:00:00

abstract：:A human colony-stimulating factor (CSF) producing cell line, T3M-1, has been established from explant cultures of a human squamous cell carcinoma of the oral cavity that secretes human CSF. It has been continously propagated during the past 15 months. The cells grew in a monolayered sheet with about 17 hr of populatio...

journal_title：Cancer research

authors： Okabe T,Sato N,Kondo Y,Asano S,Ohsawa N,Kosaka K,Ueyama Y

更新日期：1978-11-01 00:00:00

abstract：:Melanomas harboring BRAF mutations can be treated with BRAF inhibitors (BRAFi), but responses are varied and tumor recurrence is inevitable. Here we used an integrative approach of experimentation and mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxidant capacity is li...

journal_title：Cancer research

authors： Paudel BB,Lewis JE,Hardeman KN,Hayford CE,Robbins CJ,Stauffer PE,Codreanu SG,Sherrod SD,McLean JA,Kemp ML,Quaranta V

更新日期：2020-10-15 00:00:00

abstract：:The shedding of membrane vesicles from the cell surface is a vital process considered to be involved in cell-cell and cell-matrix interactions and in tumor progression. By immunoelectron microscopic analysis of surface replicas of 8701-BC human breast carcinoma cells, we observed that membrane vesicles shed from plasm...

journal_title：Cancer research

authors： Dolo V,Ginestra A,Cassarà D,Violini S,Lucania G,Torrisi MR,Nagase H,Canevari S,Pavan A,Vittorelli ML

更新日期：1998-10-01 00:00:00

abstract：:Eleven patients with advanced breast cancer and four with astrocytoma were treated with plasma perfused over columns containing staphylococcal Protein A (SPA). Doses of 5 to 20 mg of SPA were bound to collodion charcoal particles, and this treatment resulted in partial remissions in one patient with astrocytoma and in...

journal_title：Cancer research

authors： Bertram JH,Grunberg SM,Shulman I,Apuzzo ML,Boquiren D,Kunkel L,Hengst JC,Nelson J,Waugh WJ,Plotkin D

更新日期：1985-09-01 00:00:00

abstract：:We demonstrate here that paclitaxel exposure to RPMI-1788 B lymphoblasts caused a dose- and time-dependent increase in nuclear factor activator protein 1 (AP-1) DNA binding activity. The basal DNA binding activities of nuclear factors NF-kappaB and Ets were not affected by paclitaxel. Consistent with these biochemical...

journal_title：Cancer research

authors： Amato SF,Swart JM,Berg M,Wanebo HJ,Mehta SR,Chiles TC

更新日期：1998-01-15 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00

abstract：:Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to produce durable clinical responses due to the emergence of acquired drug...

journal_title：Cancer research

authors： Wang H,Daouti S,Li WH,Wen Y,Rizzo C,Higgins B,Packman K,Rosen N,Boylan JF,Heimbrook D,Niu H

更新日期：2011-08-15 00:00:00

abstract：:The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified in its regulators, including CARD11/CARMA1 (caspase recruitment domain-co...

journal_title：Cancer research

authors： Naylor TL,Tang H,Ratsch BA,Enns A,Loo A,Chen L,Lenz P,Waters NJ,Schuler W,Dörken B,Yao YM,Warmuth M,Lenz G,Stegmeier F

更新日期：2011-04-01 00:00:00

abstract：:As previously reported for natural killer (NK) cells of normal individuals, prior incubation of peripheral blood lymphocytes from cancer patients with human normal serum or monomeric immunoglobulin G reduced their subsequent capacity to kill K562 target cells in a 4-h 51Cr release assay. The NK activity of such treate...

journal_title：Cancer research

authors： Pislarasu M,Oproiu A,Taranu D,Herberman RB,Sulica A

更新日期：1988-05-01 00:00:00

abstract：:BALB/cJ X C57BL/10Sn F1 (hereafter called B10F1) hybrids resist challenge with the BALB/c plasmacytoma, MPC-11, by a radiation-sensitive, silica-insensitive mechanism, whereas BALB/cJ X BALB.B F1 (hereafter called BALB.BF1) hybrids are as susceptible to MPC-11 as are homozygous BALB/c mice themselves. To investigate t...

journal_title：Cancer research

authors： Marsili MA,Walker MC,Phillips-Quagliata JM

更新日期：1986-01-01 00:00:00