Abstract：
:In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances, consistent with an increase in tumor hypoxia during untreated growth. Following chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea (10 mg/kg), tumor levels of phosphocreatine and nucleoside triphosphate rebounded while the level of inorganic phosphate in the tumor declined. Histological comparison of treated and untreated tumor sections 4 days posttreatment showed that the treated tumor had a lower proportion of necrotic cells, a higher proportion of viable cells, and a 5-fold higher level of interstitial space than the control tumor.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Steen RG,Tamargo RJ,McGovern KA,Rajan SS,Brem H,Wehrle JP,Glickson JDsubject
Has Abstractpub_date
1988-02-01 00:00:00pages
676-81issue
3eissn
0008-5472issn
1538-7445journal_volume
48pub_type
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