The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes.

abstract：:Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC). Nonsteroidal anti-inflammatory agents (NSAIDS) inhibit growth of various CRC cell lines by both COX-dependent and COX-independent pathways. To spec...

journal_title：Cancer research

authors： Chinery R,Coffey RJ,Graves-Deal R,Kirkland SC,Sanchez SC,Zackert WE,Oates JA,Morrow JD

更新日期：1999-06-01 00:00:00

abstract：:Mutations in the ret proto-oncogene constitute the germ line defect in patients with inherited forms of medullary thyroid carcinoma (MTC) and are also present in tumor DNA from a subset of patients with sporadic forms of MTC. We now show that the TT cell line of human MTC can be induced within 48 h to resemble mature ...

journal_title：Cancer research

authors： Carson EB,McMahon M,Baylin SB,Nelkin BD

更新日期：1995-05-15 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:The influence of methotrexate (MTX), dibutyryl cyclic AMP, and actinomycin D on production of human chorionic gonadotropin (HCG) in normal first trimester human placental organ cultures was compared. Actinomycin D (10(-8) to 10(-6) M) elevated HCG production by as much as 3.5-fold in normal placenta, and a 2-fold incr...

journal_title：Cancer research

authors： Huot RI,Nardone RM,Stromberg K

更新日期：1987-01-15 00:00:00

abstract：:DDX3 is a DEAD box RNA helicase with diverse biological functions. Using colony formation assay, our results revealed that DDX3 inhibited the colony formation ability of various tumor cells, and this inhibition might be due to a reduced growth rate caused by DDX3. Additionally, we identified p21(waf1/cip1), a cyclin-d...

journal_title：Cancer research

authors： Chao CH,Chen CM,Cheng PL,Shih JW,Tsou AP,Lee YH

更新日期：2006-07-01 00:00:00

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00

abstract：:The response to Photofrin II-induced photosensitization on the activities of mitochondrial monoamine oxidase (MAO) and adenylate kinase (AK) were studied in order to gain further insight into site specific effects. Utilizing intact mitochondria in vitro, both MAO, located on the cytoplasmic side of the outer mitochond...

journal_title：Cancer research

authors： Murant RS,Gibson SL,Hilf R

更新日期：1987-08-15 00:00:00

abstract：:Therapeutic inhibition of mammalian target of rapamycin (mTOR) in cancer is complicated by the existence of a negative feedback loop linking mTOR to the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. Thus, mTOR inhibition by rapamycin or TSC1/2 results in increased PI3K-Akt activation. The death domain kinase recep...

journal_title：Cancer research

authors： Park S,Zhao D,Hatanpaa KJ,Mickey BE,Saha D,Boothman DA,Story MD,Wong ET,Burma S,Georgescu MM,Rangnekar VM,Chauncey SS,Habib AA

更新日期：2009-05-15 00:00:00

abstract：:There is an unmet need for pharmacodynamic and predictive biomarkers for antiangiogenic agents. Recent studies have shown that soluble vascular endothelial growth factor receptor 2 (sVEGFR2), VEGF, and several other soluble factors may be modulated by VEGF pathway inhibitors. We conducted a broad profiling of cytokine...

journal_title：Cancer research

authors： Nikolinakos PG,Altorki N,Yankelevitz D,Tran HT,Yan S,Rajagopalan D,Bordogna W,Ottesen LH,Heymach JV

更新日期：2010-03-15 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:Metastatic nonseminomatous testicular germ cell tumors are curable using combination chemotherapy in approximately 80% of patients. In contrast, most other patients with other types of cancer either present with or acquire drug-resistant disease following chemotherapy. Cell lines derived from testis tumors retain hype...

journal_title：Cancer research

authors： Parris CN,Walker MC,Masters JR,Arlett CF

更新日期：1990-12-01 00:00:00

abstract：:Solid tumors often contain poorly vascularized necrotic regions. In order to determine how such regions are formed within tumors and to identify substances which affect their formation, we have transformed nontumorigenic BALB/c 3T3 cells with an activated Ha-ras oncogene. Cells that were derived from independent clone...

journal_title：Cancer research

authors： Peretz D,Kimel N,Fujii DK,Neufeld G

更新日期：1993-01-01 00:00:00

abstract：:Emerging evidence supporting the activation of the Akt-mammalian target of rapamycin (mTOR) signaling network in head and neck squamous cell carcinoma (HNSCC) progression has provided the rationale for exploring the therapeutic potential of inhibiting this pathway for HNSCC treatment. Indeed, rapamycin, a clinically r...

journal_title：Cancer research

authors： Amornphimoltham P,Patel V,Leelahavanichkul K,Abraham RT,Gutkind JS

更新日期：2008-02-15 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming growth factor beta (TGF-beta) isoforms. These important growth-regulating polypeptides bind to a number of proteins, including the type I TGF-beta receptor (T beta R-I), type II TGF-beta rece...

journal_title：Cancer research

authors： Friess H,Yamanaka Y,Büchler M,Berger HG,Kobrin MS,Baldwin RL,Korc M

更新日期：1993-06-15 00:00:00

abstract：:The issue of resistance to targeted drug therapy is of pressing concern, as it constitutes a major barrier to progress in managing cancer. One important aspect is the role of stochasticity in determining the nature of the patient response. We examine two particular experiments. The first measured the maximal response ...

journal_title：Cancer research

authors： Kessler DA,Austin RH,Levine H

更新日期：2014-09-01 00:00:00

abstract：:Pancreatic cancer is a disease with limited therapeutic options. Resistance to chemotherapies poses a significant clinical challenge for patients with pancreatic cancer and contributes to a high rate of recurrence. Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic reprogramming and upregulates...

journal_title：Cancer research

authors： Mukhopadhyay S,Goswami D,Adiseshaiah PP,Burgan W,Yi M,Guerin TM,Kozlov SV,Nissley DV,McCormick F

更新日期：2020-04-15 00:00:00

abstract：:Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt th...

journal_title：Cancer research

authors： Shiftan L,Israely T,Cohen M,Frydman V,Dafni H,Stern R,Neeman M

更新日期：2005-11-15 00:00:00

abstract：:Retinoic acid inhibits the proliferation of the murine melanoma clone S91-C-2 cells, enhances the glycosylation of specific cell surface sialoglycoproteins, and stimulates sialytransferase activity. Mutant clones, selected from the S91-C-2 cells for resistance to the growth-inhibitory effect of retinoic acid, were use...

journal_title：Cancer research

authors： Lotan R,Lotan D,Meromsky L

更新日期：1984-12-01 00:00:00

abstract：:The initiation-promotion model for the production of skin tumors in mice has proven useful for studying the influence of nutritional variations on stages in neoplasia. Specifically, restriction in caloric intake or fat level in the diet as well as a supplemental retinoid protect against tumor promotion. In contrast, t...

journal_title：Cancer research

authors： Boutwell RK

更新日期：1983-05-01 00:00:00

abstract：:The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on Notch signaling in tumor cells expressing Notch receptors remain, however, largely unknown. Here, we report that escape of human T-c...

journal_title：Cancer research

authors： Indraccolo S,Minuzzo S,Masiero M,Pusceddu I,Persano L,Moserle L,Reboldi A,Favaro E,Mecarozzi M,Di Mario G,Screpanti I,Ponzoni M,Doglioni C,Amadori A

更新日期：2009-02-15 00:00:00

abstract：:The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

journal_title：Cancer research

authors： Howard RA,Spring TG,Bear JL

更新日期：1976-12-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a promising cancer treatment involving the administration of a tumor-localizing photosensitizer followed by the photochemical generation of cytotoxic singlet oxygen. PDT elicits strong transcriptional activation of a variety of genes including stress response genes belonging to the glucos...

journal_title：Cancer research

authors： Luna MC,Chen X,Wong S,Tsui J,Rucker N,Lee AS,Gomer CJ

更新日期：2002-03-01 00:00:00

abstract：:Methotrexate (MTX) is one of the most commonly used agents in the treatment of solid malignancies; however, the toxicities of MTX to bone marrow and gastrointestinal tract complicate this therapy. We, therefore, propose a gene-dependent enzyme prodrug therapy to limit these toxicities by localizing the production of M...

journal_title：Cancer research

authors： Hamstra DA,Pagé M,Maybaum J,Rehemtulla A

更新日期：2000-02-01 00:00:00

abstract：:Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation...

journal_title：Cancer research

authors： Brooks GD,McLeod L,Alhayyani S,Miller A,Russell PA,Ferlin W,Rose-John S,Ruwanpura S,Jenkins BJ

更新日期：2016-02-15 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation, and apoptosis, including acting as a switch for Bcl-2 function. We previously reported that the octaketide cytosporone B (Csn-B) is a natural agonist for Nur77. In this study, we synthesized a series of Csn-B an...

journal_title：Cancer research

authors： Liu JJ,Zeng HN,Zhang LR,Zhan YY,Chen Y,Wang Y,Wang J,Xiang SH,Liu WJ,Wang WJ,Chen HZ,Shen YM,Su WJ,Huang PQ,Zhang HK,Wu Q

更新日期：2010-05-01 00:00:00

abstract：:AS1411 is a first-in-class anticancer agent, currently in phase II clinical trials. It is a quadruplex-forming oligodeoxynucleotide that binds to nucleolin as an aptamer, but its mechanism of action is not completely understood. Mechanistic insights could lead to clinically useful markers for AS1411 response and to no...

journal_title：Cancer research

authors： Reyes-Reyes EM,Teng Y,Bates PJ

更新日期：2010-11-01 00:00:00

abstract：:The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and vitamin D. Activati...

journal_title：Cancer research

authors： Dreijerink KM,Mulder KW,Winkler GS,Höppener JW,Lips CJ,Timmers HT

更新日期：2006-05-01 00:00:00

abstract：:Hypoxia within solid tumors decreases therapeutic efficacy, and identification of hypoxia markers may influence the choice of therapeutic modality. Here, we used a proteomic approach to identify hypoxia-regulated proteins and validated their use as endogenous indicators of tumor hypoxia. Using two-dimensional gel elec...

journal_title：Cancer research

authors： Chen Y,Shi G,Xia W,Kong C,Zhao S,Gaw AF,Chen EY,Yang GP,Giaccia AJ,Le QT,Koong AC

更新日期：2004-10-15 00:00:00