Abstract：
:The biological behavior of a number of nude mouse-grown human epithelial tumors of different histogenetic background was studied. They included three transitional cell carcinomas and a mucin-producing carcinoma of the urinary bladder, two pancreatic adenocarcinomas, a colon adenocarcinoma, a breast ductal carcinoma, and an epidermoid carcinoma. Microinvasion was a constant finding in all tumors examined. All but one of the tumors studied showed macroinvasion and metastases. Tumors transplanted s.c. in the anterior aspect of the lateral thoracic wall metastasized primarily to the regional and mediastinal lymph nodes. In certain cases, systemic metastases were observed affecting the submaxillary, contralateral axillary, and inguinal lymph nodes. Lung metastases occurred through the lymphatic and hematogenous routes. It is concluded that the nude mouse-grown human tumors investigated in the present study show overt malignant behavior recapitulating the biological characteristics of the tumor of origin.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kyriazis AP,Kyriazis AA,McCombs WB 3rd,Kereiakes JAsubject
Has Abstractpub_date
1981-10-01 00:00:00pages
3995-4000issue
10eissn
0008-5472issn
1538-7445journal_volume
41pub_type
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