Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action is unclear. Treatment with PS-341 induces apoptosis in SUDHL6 (DHL6), but not SUDHL4 (DHL4), lymphoma cells. Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4...

journal_title：Cancer research

authors： Chauhan D,Li G,Shringarpure R,Podar K,Ohtake Y,Hideshima T,Anderson KC

更新日期：2003-10-01 00:00:00

abstract：:The cytoskeleton, the shape, and the adhesion complexes of MCF-7 breast carcinoma cells have been studied by fluorescence, phase contrast, and interference reflection microscopy. Cells have been grown in media containing different concentrations of estrogen and with or without the addition of the antiestrogen tamoxife...

journal_title：Cancer research

authors： Sapino A,Pietribiasi F,Bussolati G,Marchisio PC

更新日期：1986-05-01 00:00:00

abstract：:Dickkopf3 (DKK3) is a secretory protein that belongs to the DKK family, but exhibits structural divergence from other family members, and its corresponding receptors remain to be identified. Although DKK3 has been shown to have oncogenic functions in certain cancer types, the underlying mechanism by which DKK3 promote...

journal_title：Cancer research

authors： Kajiwara C,Fumoto K,Kimura H,Nojima S,Asano K,Odagiri K,Yamasaki M,Hikita H,Takehara T,Doki Y,Morii E,Kikuchi A

更新日期：2018-11-01 00:00:00

abstract：:The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is...

journal_title：Cancer research

authors： Kuzu OF,Noory MA,Robertson GP

更新日期：2016-04-15 00:00:00

abstract：:Chronic myelogenous leukemia is characterized by a specific chromosomal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chimeric BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, whi...

journal_title：Cancer research

authors： ten Hoeve J,Kaartinen V,Fioretos T,Haataja L,Voncken JW,Heisterkamp N,Groffen J

更新日期：1994-05-15 00:00:00

abstract：:Malignant and uninvolved human breast tissues were maintained in organ culture for 3 to 6 days. Under these conditions, the three-dimensional glandular architecture is maintained with the least disruption of tissue integrity. The biosynthesis and release of glycoproteins were studied by using the incorporation of [14C...

journal_title：Cancer research

authors： Gendler SJ,Dermer GB,Silverman LM,Tökés ZA

更新日期：1982-11-01 00:00:00

abstract：:It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in the etiology of pancreatic cancer, we have analyzed samples from patients with pancreatic cancer enrolled in the NFPTR for mutations...

journal_title：Cancer research

authors： Murphy KM,Brune KA,Griffin C,Sollenberger JE,Petersen GM,Bansal R,Hruban RH,Kern SE

更新日期：2002-07-01 00:00:00

abstract：:Proper implementation of direct injection clearance techniques to measure tumor blood flow (TBF) requires knowledge of the tracer distribution because TBF distribution is often inhomogeneous. Therefore, deuterium nuclear magnetic resonance imaging was used to follow tracer (HOD) distribution after direct injection of ...

journal_title：Cancer research

authors： Larcombe McDouall JB,Evelhoch JL

更新日期：1990-01-15 00:00:00

abstract：:The effect of 0.0001 to 10 muM 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1 muM dexamethasone on cell proliferation was studied by measuring cell densities in control and drug-treated rat glioma (strain C6) monolayer cultures. When C6 cultures were exposed to 0.01 to 10 muM BCNU, the growth rates decreased for 2 ...

journal_title：Cancer research

authors： Grasso RJ,Johnson CE,Boler RK,Moore NA

更新日期：1977-02-01 00:00:00

abstract：:We recently reported on the pharmacokinetics in 14 cancer patients of the 19-9 antibody radiolabeled with 111In. We have now repeated this investigation in 18 cancer patients using the OC-125 antibody, in part to compare the in vivo behavior of two murine monoclonal antibodies of the same subclass administered as the ...

journal_title：Cancer research

authors： Hnatowich DJ,Gionet M,Rusckowski M,Siebecker DA,Roche J,Shealy D,Mattis JA,Wilson J,McGann J,Hunter RE

更新日期：1987-11-15 00:00:00

abstract：:The motuporamines are macrocyclic alkaloids that inhibit tumor cell invasion by an, as yet, unknown mechanism. A structure-activity study recently identified dihydromotuporamine C (dhMotC) as a highly active and readily synthesized analogue. Here, we show that dhMotC causes subtle cytoskeletal alterations in highly in...

journal_title：Cancer research

authors： McHardy LM,Sinotte R,Troussard A,Sheldon C,Church J,Williams DE,Andersen RJ,Dedhar S,Roberge M,Roskelley CD

更新日期：2004-02-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown to be the essential mediator of most Smad-dependent TGF-beta responses, including control...

journal_title：Cancer research

authors： Yang J,Wahdan-Alaswad R,Danielpour D

更新日期：2009-03-15 00:00:00

abstract：:The effect of a number of steroids, growth factors, and peptides on aromatase activity in two estrogen receptor positive breast cancer cell lines (MCF7 and T47D) was investigated. The cells were incubated in Dulbecco's minimum essential medium containing phenol red and 10% fetal calf serum. Pronounced differences in b...

journal_title：Cancer research

authors： Ryde CM,Nicholls JE,Dowsett M

更新日期：1992-03-15 00:00:00

abstract：:About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 c...

journal_title：Cancer research

authors： Kemp ZE,Carvajal-Carmona LG,Barclay E,Gorman M,Martin L,Wood W,Rowan A,Donohue C,Spain S,Jaeger E,Evans DG,Maher ER,Bishop T,Thomas H,Houlston R,Tomlinson I,Colorectal Tumour Gene Identification Study Consortium.

更新日期：2006-05-15 00:00:00

abstract：:The PDLIM2 protein regulates stability of transcription factors including NF-κB and STATs in epithelial and hemopoietic cells. PDLIM2 is strongly expressed in certain cancer cell lines that exhibit an epithelial-to-mesenchymal phenotype, and its suppression is sufficient to reverse this phenotype. PDLIM2 supports the ...

journal_title：Cancer research

authors： Cox OT,Edmunds SJ,Simon-Keller K,Li B,Moran B,Buckley NE,Bustamante-Garrido M,Healy N,O'Flanagan CH,Gallagher WM,Kennedy RD,Bernards R,Caldas C,Chin SF,Marx A,O'Connor R

更新日期：2019-05-15 00:00:00

abstract：:Shorter alleles of a polymorphic [CAG](n) repeat in exon 1 of the androgen receptor (AR) have been associated with increased risk of prostate cancer and decreased risk of breast cancer. We prospectively assessed the association between the [CAG](n) repeat polymorphism in the androgen receptor and breast cancer risk am...

journal_title：Cancer research

authors： Haiman CA,Brown M,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Kantoff PW,Hunter DJ

更新日期：2002-02-15 00:00:00

abstract：:The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity and DNA synthesis were examined in human CCRF-CEM leukemic cells following a continuous exposure to these agents. In logarithmically growing control tumor cells, the rate of in situ thymidy...

journal_title：Cancer research

authors： Fernandes DJ,Cranford SK

更新日期：1986-04-01 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:Hollow organs lined by columnar epithelial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen. These heterogeneously O-glycosylated molecules are known to aberrantly enter the bloodstream in the setting of epithelial carcinomas and possibly during injury or inflammation. We have r...

journal_title：Cancer research

authors： Wahrenbrock MG,Varki A

更新日期：2006-02-15 00:00:00

abstract：:The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 a...

journal_title：Cancer research

authors： Nedelcheva Kristensen V,Haraldsen EK,Anderson KB,Lønning PE,Erikstein B,Kåresen R,Gabrielsen OS,Børresen-Dale AL

更新日期：1999-06-15 00:00:00

abstract：:N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Sub...

journal_title：Cancer research

authors： Mattammal MB,Zenser TV,Palmier MO,Davis BB

更新日期：1985-01-01 00:00:00

abstract：:The addition of B-cell lymphoma 2 (Bcl-2) antisense to dacarbazine in the treatment of metastatic melanoma demonstrates improved response rates and progression-free survival when compared with dacarbazine alone. Studies on small cohorts of melanoma patients have shown variability in Bcl-2 expression (60%-96% positive)...

journal_title：Cancer research

authors： Divito KA,Berger AJ,Camp RL,Dolled-Filhart M,Rimm DL,Kluger HM

更新日期：2004-12-01 00:00:00

abstract：:Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) on cancer cells in vitro and in vivo. Surface plasmon resonance re...

journal_title：Cancer research

authors： Pavet V,Beyrath J,Pardin C,Morizot A,Lechner MC,Briand JP,Wendland M,Maison W,Fournel S,Micheau O,Guichard G,Gronemeyer H

更新日期：2010-02-01 00:00:00

abstract：:Cancer cell motility has been associated with metastatic potential of sublines of the Dunning R-3227 rat prostatic adenocarcinoma model. However, three sublines of high motility lacked the capacity for metastasis. In all previous works, motility has been studied upon plastic and only upon attached cells at least 18 h ...

journal_title：Cancer research

authors： Mohler JL,Levy F,Sharief Y

更新日期：1991-12-15 00:00:00

abstract：:Death receptor Fas-mediated apoptosis not only eliminates nonspecific and autoreactive B cells but also plays a major role in antitumor immunity. However, the possible mechanisms underlying impairment of Fas-mediated induction of apoptosis during lymphomagenesis remain unknown. In this study, we employed our developed...

journal_title：Cancer research

authors： Sugihara E,Hashimoto N,Osuka S,Shimizu T,Ueno S,Okazaki S,Yaguchi T,Kawakami Y,Kosaki K,Sato TA,Okamoto S,Saya H

更新日期：2020-10-15 00:00:00

abstract：:We investigated the relationship between DNA cytosine methylation and the expression of two genes associated with resistance to DNA methylation damage. Variants of RajiMex- cells acquired resistance to N-methyl-N-nitrosourea by either reactivating a previously silent O6-methylguanine-DNA methyltransferase (MGMT) gene ...

journal_title：Cancer research

authors： Bearzatto A,Szadkowski M,Macpherson P,Jiricny J,Karran P

更新日期：2000-06-15 00:00:00

abstract：:Fusion proteins consisting of the extracellular region of murine B7.1 or B7.2 and the Fc portion of murine IgG2a (B7-IgG) were evaluated for their ability to promote antitumor responses. Therapeutic administration of soluble B7-IgG in mice with established tumors induced complete regression of the tumor and increased ...

journal_title：Cancer research

authors： Sturmhoefel K,Lee K,Gray GS,Thomas J,Zollner R,O'Toole M,Swiniarski H,Dorner A,Wolf SF

更新日期：1999-10-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression. We have tested the hypothesis that progressive cell clustering controls the proteolytic cascad...

journal_title：Cancer research

authors： Lunter PC,van Kilsdonk JW,van Beek H,Cornelissen IM,Bergers M,Willems PH,van Muijen GN,Swart GW

更新日期：2005-10-01 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local X-irradiation, or combined local hyperthermia and X-irradiation. Twenty-four hr posttreatment, the animals were inoculated with the metastatic Lewis lung carci...

journal_title：Cancer research

authors： Yerushalmi A,Weinstein Y

更新日期：1979-03-01 00:00:00