p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4.

abstract：:GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like conformation of EGFR that is ver...

journal_title：Cancer research

authors： Wood ER,Truesdale AT,McDonald OB,Yuan D,Hassell A,Dickerson SH,Ellis B,Pennisi C,Horne E,Lackey K,Alligood KJ,Rusnak DW,Gilmer TM,Shewchuk L

更新日期：2004-09-15 00:00:00

abstract：:In 1956, Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the Pasteur effect (i.e., the inhibition of anaerobic fermentation by oxygen). Since then, permanent defects in oxygen consumption that could explain the dependence of cancer cells on aerob...

journal_title：Cancer research

authors： Samudio I,Fiegl M,McQueen T,Clise-Dwyer K,Andreeff M

更新日期：2008-07-01 00:00:00

abstract：:We have investigated the ability of several drugs commonly used in the treatment of human cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute leukemia, lymphoma, breast cancer, and prostate cancer. The results of this analysis indicate that drugs affecting the integrity of micro...

journal_title：Cancer research

authors： Haldar S,Basu A,Croce CM

更新日期：1997-01-15 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublin...

journal_title：Cancer research

authors： Kondo A,Safaei R,Mishima M,Niedner H,Lin X,Howell SB

更新日期：2001-10-15 00:00:00

abstract：:Aberrant promoter hypermethylation and associated gene silencing are epigenetic hallmarks of tumorigenesis. It has been suggested that aberrant DNA methylation can affect the sensitivity of cancers to antineoplastic agents by altering expression of genes critical to drug response. To study this issue, we used bisulfit...

journal_title：Cancer research

authors： Shen L,Kondo Y,Ahmed S,Boumber Y,Konishi K,Guo Y,Chen X,Vilaythong JN,Issa JP

更新日期：2007-12-01 00:00:00

abstract：:Our previous studies have defined reactive stroma in human prostate cancer and have developed the differential reactive stroma (DRS) xenograft model to evaluate mechanisms of how reactive stroma promotes carcinoma tumorigenesis. Analysis of several normal human prostate stromal cell lines in the DRS model showed that ...

journal_title：Cancer research

authors： Yang F,Tuxhorn JA,Ressler SJ,McAlhany SJ,Dang TD,Rowley DR

更新日期：2005-10-01 00:00:00

abstract：:In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer types. However, whereas some studies have identified elevated NEDD9 expression as prometastatic, other work has suggested a negative role in tumor progression. We here...

journal_title：Cancer research

authors： Izumchenko E,Singh MK,Plotnikova OV,Tikhmyanova N,Little JL,Serebriiskii IG,Seo S,Kurokawa M,Egleston BL,Klein-Szanto A,Pugacheva EN,Hardy RR,Wolfson M,Connolly DC,Golemis EA

更新日期：2009-09-15 00:00:00

abstract：:The acute hemorrhagic necrosis of tumor nodules caused by the systemic administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) has been partially attributed to changes in tumor neovascularity. In this study, the effects of rhTNF-alpha were tested on primary autochthonous sarcomas induced in C57BL...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Travis WD,Rosenberg SA

更新日期：1990-04-15 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00

abstract：:Meningiomas constitute the second most common central nervous system tumor, and yet relatively little is known about the molecular events that are important for the pathogenesis and malignant progression of these tumors. We have used serial analysis of gene expression to compare the transcriptomes of nonneoplastic men...

journal_title：Cancer research

authors： Cuevas IC,Slocum AL,Jun P,Costello JF,Bollen AW,Riggins GJ,McDermott MW,Lal A

更新日期：2005-06-15 00:00:00

abstract：:Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we util...

journal_title：Cancer research

authors： Kather JN,Poleszczuk J,Suarez-Carmona M,Krisam J,Charoentong P,Valous NA,Weis CA,Tavernar L,Leiss F,Herpel E,Klupp F,Ulrich A,Schneider M,Marx A,Jäger D,Halama N

更新日期：2017-11-15 00:00:00

abstract：:Human glandular kallikrein (hK2) and prostate-specific antigen (PSA) are related members of the human kallikrein gene family. The genes for hK2 and PSA are expressed predominately in the prostate, are transcriptionally up-regulated by androgens, and share 78% homology. Previously, one functional androgen response elem...

journal_title：Cancer research

authors： Yu DC,Sakamoto GT,Henderson DR

更新日期：1999-04-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:A translationally regulated, dominant-negative isoform of CCAAT/enhancer-binding protein beta is expressed in transplantable and primary mouse mammary tumors of different etiologies but is not expressed in preneoplastic mammary hyperplasias or in primary prostate, lung, lens, ovary or lymphoid tumors. The eukaryotic i...

journal_title：Cancer research

authors： Raught B,Gingras AC,James A,Medina D,Sonenberg N,Rosen JM

更新日期：1996-10-01 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:The in vivo activation of aflatoxin B1 (AFB1) was assessed by using two transgenic mouse lines, M2 and M10, in which the human fetus-specific CYP3A7 was expressed in the kidney (M2) and the liver (M10), respectively. Male mice of 8 weeks old from these two lines were treated with a single i.p. injection of AFB1 (4 mg/...

journal_title：Cancer research

authors： Li Y,Yokoi T,Katsuki M,Wang JS,Groopman JD,Kamataki T

更新日期：1997-02-15 00:00:00

abstract：:It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinoge...

journal_title：Cancer research

authors： Delclos KB,el-Bayoumy K,Casciano DA,Walker RP,Kadlubar FF,Hecht SS,Shivapurkar N,Mandal S,Stoner GD

更新日期：1989-06-01 00:00:00

abstract：:Huggins and Morii (J. Exp. Med., 114: 741, 1961) reported that massive adrenal necrosis occurs in 79 and 100% of female Sprague-Dawley rats receiving 20 and 30 mg, respectively, of the mammary carcinogen 7,12-dimethylbenz(a)anthracene (DMBA). Here, adrenal necrosis and regeneration were studied in 158 rats for up to 2...

journal_title：Cancer research

authors： Carter JH,Carter HW,Meade J

更新日期：1988-07-01 00:00:00

abstract：:By molecular genetic approach using polymorphic DNA markers which detect allelic deletion at specific chromosomal loci, we analyzed 30 human stomach cancers for possible loss of chromosomal heterozygosity. We analyzed 25 loci on 18 different chromosomes covering regions frequently deleted in several types of cancers. ...

journal_title：Cancer research

authors： Wada M,Yokota J,Mizoguchi H,Sugimura T,Terada M

更新日期：1988-06-01 00:00:00

abstract：:Galectin-3 (Gal-3), a pleiotropic carbohydrate-binding protein, is a selective binding partner of activated K-Ras-GTP. Because both proteins are antiapoptotic and associated with cancer progression, we questioned the possible functional role of Gal-3 in K-Ras activation. We found that overexpression of Gal-3 in human ...

journal_title：Cancer research

authors： Shalom-Feuerstein R,Cooks T,Raz A,Kloog Y

更新日期：2005-08-15 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic ina...

journal_title：Cancer research

authors： Ragazzon B,Libé R,Gaujoux S,Assié G,Fratticci A,Launay P,Clauser E,Bertagna X,Tissier F,de Reyniès A,Bertherat J

更新日期：2010-11-01 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:Gli signaling is critical for central nervous system development and is implicated in tumorigenesis. To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor-induced gliomas in a Gli-luciferase reporter mouse. We find that Gli activation is found in gliomas and correlates with grade. In a...

journal_title：Cancer research

authors： Becher OJ,Hambardzumyan D,Fomchenko EI,Momota H,Mainwaring L,Bleau AM,Katz AM,Edgar M,Kenney AM,Cordon-Cardo C,Blasberg RG,Holland EC

更新日期：2008-04-01 00:00:00

abstract：:In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggestin...

journal_title：Cancer research

authors： Rivest RS,Irwin D,Mandel HG

更新日期：1982-10-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose. Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleo...

journal_title：Cancer research

authors： Merski JA,Daskal I,Busch H

更新日期：1976-05-01 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb and related proteins p107 and pRb2/p130. Ectopic expression of pRb and p107 results in a growth arrest of sensitive cells in the G1 phase of the cell cycle. We demonstrated here that the growth-suppressive properties of pRb2/p130 were also specific fo...

journal_title：Cancer research

authors： Claudio PP,De Luca A,Howard CM,Baldi A,Firpo EJ,Koff A,Paggi MG,Giordano A

更新日期：1996-05-01 00:00:00