Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis.

Abstract:

:Our previous studies have defined reactive stroma in human prostate cancer and have developed the differential reactive stroma (DRS) xenograft model to evaluate mechanisms of how reactive stroma promotes carcinoma tumorigenesis. Analysis of several normal human prostate stromal cell lines in the DRS model showed that some rapidly promoted LNCaP prostate carcinoma cell tumorigenesis and others had no effect. These differential effects were due, in part, to elevated angiogenesis and were transforming growth factor (TGF)-beta1 mediated. The present study was conducted to identify and evaluate candidate genes expressed in prostate stromal cells responsible for this differential tumor-promoting activity. Differential cDNA microarray analyses showed that connective tissue growth factor (CTGF) was expressed at low levels in nontumor-promoting prostate stromal cells and was constitutively expressed in tumor-promoting prostate stromal cells. TGF-beta1 stimulated CTGF message expression in nontumor-promoting prostate stromal cells. To evaluate the role of stromal-expressed CTGF in tumor progression, either engineered mouse prostate stromal fibroblasts expressing retroviral-introduced CTGF or 3T3 fibroblasts engineered with mifepristone-regulated CTGF were combined with LNCaP human prostate cancer cells in the DRS xenograft tumor model under different extracellular matrix conditions. Expression of CTGF in tumor-reactive stroma induced significant increases in microvessel density and xenograft tumor growth under several conditions tested. These data suggest that CTGF is a downstream mediator of TGF-beta1 action in cancer-associated reactive stroma and is likely to be one of the key regulators of angiogenesis in the tumor-reactive stromal microenvironment.

journal_name

Cancer Res

journal_title

Cancer research

authors

Yang F,Tuxhorn JA,Ressler SJ,McAlhany SJ,Dang TD,Rowley DR

doi

10.1158/0008-5472.CAN-05-1702

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

8887-95

issue

19

eissn

0008-5472

issn

1538-7445

pii

65/19/8887

journal_volume

65

pub_type

杂志文章
  • Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

    abstract::Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary and nine metastatic hum...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Vlietstra RJ,van Alewijk DC,Hermans KG,van Steenbrugge GJ,Trapman J

    更新日期:1998-07-01 00:00:00

  • Host-mediated therapeutic effects produced by appropriately timed administration of bleomycin on a rat fibrosarcoma.

    abstract::The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect was observed when BLM (5 mg/kg/day) was administered i.p. for 5 days from the eighth day after tumor inoculation (Day 8 to D...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Morikawa K,Hosokawa M,Hamada J,Sugawara M,Kobayashi H

    更新日期:1985-04-01 00:00:00

  • Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions.

    abstract::The effect of microenvironmental factors on the regulation of intracellular pH (pHi) in MGH U1 cells and EMT-6 cells was studied using the fluorescent pH probe 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein. Na+/H+ exchange and Na(+)-dependent Cl-/HCO3- exchange were found to be present in both cell types. Th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Boyer MJ,Tannock IF

    更新日期:1992-08-15 00:00:00

  • Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.

    abstract::Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of epithelial differentiation. They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positi...

    journal_title:Cancer research

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Ladanyi M,Antonescu CR,Leung DH,Woodruff JM,Kawai A,Healey JH,Brennan MF,Bridge JA,Neff JR,Barr FG,Goldsmith JD,Brooks JS,Goldblum JR,Ali SZ,Shipley J,Cooper CS,Fisher C,Skytting B,Larsson O

    更新日期:2002-01-01 00:00:00

  • Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium.

    abstract::Overexpression of cyclin D1 is believed to endow mammary epithelial cells (MEC) with a proliferative advantage by virtue of its contribution to pRB inactivation. Accordingly, abrogation of the kinase-dependent function of cyclin D1 is sufficient to render mice resistant to breast cancer initiated by ErbB2. Here, we re...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-4139

    authors: Brown NE,Jeselsohn R,Bihani T,Hu MG,Foltopoulou P,Kuperwasser C,Hinds PW

    更新日期:2012-12-15 00:00:00

  • TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.

    abstract::Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-18-2986

    authors: Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

    更新日期:2019-07-01 00:00:00

  • Detection and partial characterization of receptors for [D-Trp6]-luteinizing hormone-releasing hormone and epidermal growth factor in human endometrial carcinoma.

    abstract::In view of advancements in treatment of certain hormone-dependent cancers with analogues of luteinizing hormone-releasing hormone (LH-RH), this study was undertaken to establish the presence and characteristics of receptors for [D-Trp6]LH-RH on the membranes of human endometrial cancer. Specific binding of [125I,D-Trp...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Srkalovic G,Wittliff JL,Schally AV

    更新日期:1990-03-15 00:00:00

  • Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement.

    abstract::Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationw...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Akre K,Signorello LB,Engstrand L,Bergström R,Larsson S,Eriksson BI,Nyrén O

    更新日期:2000-11-15 00:00:00

  • Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.

    abstract::Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

    更新日期:2002-08-15 00:00:00

  • Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.

    abstract::Epidemiological studies have shown a positive association of colon cancer with hyperlipidemia. Furthermore, signaling generated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma ligands, suggested to be candidate tumor preventive agents, has been shown to lower serum triglyceride levels. In the pres...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Niho N,Takahashi M,Kitamura T,Shoji Y,Itoh M,Noda T,Sugimura T,Wakabayashi K

    更新日期:2003-09-15 00:00:00

  • Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.

    abstract::Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-0106

    authors: Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

    更新日期:2020-08-15 00:00:00

  • Adaptive therapy.

    abstract::A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy frequently fails due to emergence of resistant populations. The latter reflects the temporal and spatial heterogeneity of the tumor microenvironment as well as the evol...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-3658

    authors: Gatenby RA,Silva AS,Gillies RJ,Frieden BR

    更新日期:2009-06-01 00:00:00

  • Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.

    abstract::Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients is restricted, such as in poorly vascularized tumor areas. We sh...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-19-0650

    authors: Kaymak I,Maier CR,Schmitz W,Campbell AD,Dankworth B,Ade CP,Walz S,Paauwe M,Kalogirou C,Marouf H,Rosenfeldt MT,Gay DM,McGregor GH,Sansom OJ,Schulze A

    更新日期:2020-01-15 00:00:00

  • Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations.

    abstract::Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asians, arguing against any of these being causative variants. This study sought to identify other varia...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-0081

    authors: Wu C,Hu Z,Yu D,Huang L,Jin G,Liang J,Guo H,Tan W,Zhang M,Qian J,Lu D,Wu T,Lin D,Shen H

    更新日期:2009-06-15 00:00:00

  • Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.

    abstract::LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development bloc...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-4774

    authors: Appert A,Nam CH,Lobato N,Priego E,Miguel RN,Blundell T,Drynan L,Sewell H,Tanaka T,Rabbitts T

    更新日期:2009-06-01 00:00:00

  • Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell.

    abstract::Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ways DK,Dodd RC,Earp HS

    更新日期:1987-07-01 00:00:00

  • CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.

    abstract::B-cell precursor acute lymphoblastic leukemia (BCP-ALL/B-precursor ALL) is characterized by a high rate of tissue infiltration. The mechanism of BCP-ALL cell extravasation is not fully understood. In the present study, we have investigated the major carrier of carbohydrate selectin ligands in the BCP-ALL cell line NAL...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-1459

    authors: Nonomura C,Kikuchi J,Kiyokawa N,Ozaki H,Mitsunaga K,Ando H,Kanamori A,Kannagi R,Fujimoto J,Muroi K,Furukawa Y,Nakamura M

    更新日期:2008-02-01 00:00:00

  • The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.

    abstract::Cell cycle arrest in G2 phase is a common response to a variety of DNA-damaging agents. The coupling between DNA damage and G2 arrest was studied in synchronized HeLa cells using camptothecin, a highly specific inhibitor of topoisomerase I that damages DNA through the formation of reversible topoisomerase I-DNA cleava...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tsao YP,D'Arpa P,Liu LF

    更新日期:1992-04-01 00:00:00

  • Pharmacokinetics of tiazofurin in the plasma and cerebrospinal fluid of rhesus monkeys.

    abstract::The pharmacokinetic disposition of tiazofurin in plasma and cerebrospinal fluid was examined in rhesus monkeys. Tiazofurin was readily detectable in both plasma and cerebrospinal fluid within 20 min of commencement and for 24 h after a short i.v. infusion of the drug. The mean clearance of tiazofurin from plasma was 7...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Grygiel JJ,Balis FM,Collins JM,Lester CM,Poplack DG

    更新日期:1985-05-01 00:00:00

  • The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.

    abstract::Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP is expressed at higher levels in a wide variety of solid tumors than in the adjacent nonneoplastic tissues. Patients with...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Matsushita S,Nitanda T,Furukawa T,Sumizawa T,Tani A,Nishimoto K,Akiba S,Miyadera K,Fukushima M,Yamada Y,Yoshida H,Kanzaki T,Akiyama S

    更新日期:1999-04-15 00:00:00

  • Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer.

    abstract::TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-2637

    authors: Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

    更新日期:2015-02-15 00:00:00

  • Population-based case-control study of ovarian cancer in Shanghai.

    abstract::A case-control study of 229 ovarian cancer cases (including 172 epithelial tumors) and an equal number of population-based controls was conducted during 1984 to 1986 in Shanghai, China, a low-risk area for ovarian cancer. Similar to studies in high-risk areas, the risk of epithelial tumors was high for nulliparous wom...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Shu XO,Brinton LA,Gao YT,Yuan JM

    更新日期:1989-07-01 00:00:00

  • Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.

    abstract::ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice varian...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-4766

    authors: Maretzky T,Le Gall SM,Worpenberg-Pietruk S,Eder J,Overall CM,Huang XY,Poghosyan Z,Edwards DR,Blobel CP

    更新日期:2009-06-01 00:00:00

  • Interferon effect on collagen and fibronectin distribution in the extracellular matrix of murine sarcoma virus-transformed cells.

    abstract::The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gerfaux J,Rousset S,Chany-Fournier F,Chany C

    更新日期:1981-09-01 00:00:00

  • Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota.

    abstract::Mortality surveys and death certificate studies have suggested an association between leukemia and farming. To investigate whether exposure to carcinogens in an agricultural setting is related to risk of leukemia, the authors conducted a population-based case-control interview study of 578 white men with leukemia and ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Brown LM,Blair A,Gibson R,Everett GD,Cantor KP,Schuman LM,Burmeister LF,Van Lier SF,Dick F

    更新日期:1990-10-15 00:00:00

  • Lipid-mediated protein delivery of suicide nucleoside kinases.

    abstract::Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Zheng X,Lundberg M,Karlsson A,Johansson M

    更新日期:2003-10-15 00:00:00

  • Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice.

    abstract::The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has inc...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-04-1918

    authors: Schimmer AD

    更新日期:2004-10-15 00:00:00

  • Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.

    abstract::The enhancer pioneer transcription factor FoxA1 is a global mediator of steroid receptor (SR) action in hormone-dependent cancers. In castration-resistant prostate cancer (CRPC), FoxA1 acts as an androgen receptor cofactor to drive G₂ to M-phase cell-cycle transit. Here, we describe a mechanistically distinct SR-indep...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-1882

    authors: Zhang C,Wang L,Wu D,Chen H,Chen Z,Thomas-Ahner JM,Zynger DL,Eeckhoute J,Yu J,Luo J,Brown M,Clinton SK,Nephew KP,Huang TH,Li W,Wang Q

    更新日期:2011-11-01 00:00:00

  • herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

    abstract::The human ether-a-go-go-related gene (herg) encodes a K+ current (IHERG) that plays a fundamental role in heart excitability by regulating the action potential repolarization (IKr); mutations of this gene are responsible for the chromosome 7-linked long QT syndrome (LQT2). In this report, we show that in a variety (n ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bianchi L,Wible B,Arcangeli A,Taglialatela M,Morra F,Castaldo P,Crociani O,Rosati B,Faravelli L,Olivotto M,Wanke E

    更新日期:1998-02-15 00:00:00

  • The oncogene qin codes for a transcriptional repressor.

    abstract::The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Li J,Chang HW,Lai E,Parker EJ,Vogt PK

    更新日期:1995-12-01 00:00:00