Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy.

abstract：:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not on...

journal_title：Cancer research

authors： Hiraga T,Williams PJ,Mundy GR,Yoneda T

更新日期：2001-06-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is activated in the majority of melanomas, and its activity is essential for cell survival. In this report, we examined the effects of a novel raf inhibitor BAY 43-9006 on melanoma cell viability and intracellular signaling and found that it induces apoptosis through a caspase-i...

journal_title：Cancer research

authors： Panka DJ,Wang W,Atkins MB,Mier JW

更新日期：2006-02-01 00:00:00

abstract：:The development of mouse models with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets provides an excellent opportunity to compare the mutant frequency (Mf) and types of mutations induced in vivo in different sequence contexts. To this end, a study was...

journal_title：Cancer research

authors： Walker VE,Gorelick NJ,Andrews JL,Craft TR,deBoer JG,Glickman BW,Skopek TR

更新日期：1996-10-15 00:00:00

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:The serum levels of an adrenal sex hormone, dehydroepiandrosterone sulfate (DHEA-S), are significantly more decreased in human myelomas compared with the reduction brought by physiologic decline with age. In order to clarify the effect of DHEA on myeloma cells, we investigated whether DHEA and DHEA-S could inhibit int...

journal_title：Cancer research

authors： Liu S,Ishikawa H,Li FJ,Ma Z,Otsuyama K,Asaoku H,Abroun S,Zheng X,Tsuyama N,Obata M,Kawano MM

更新日期：2005-03-15 00:00:00

abstract：:Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype, which is implicated in age-related pathologies including cancer. Here, we report that senescent cells active...

journal_title：Cancer research

authors： Han L,Long Q,Li S,Xu Q,Zhang B,Dou X,Qian M,Jiramongkol Y,Guo J,Cao L,Chin YE,Lam EW,Jiang J,Sun Y

更新日期：2020-08-15 00:00:00

abstract：:Both gastrin and Helicobacter pylori have been shown capable of up-regulating gene expression and protein shedding of heparin-binding epidermal growth factor (HB-EGF). Furthermore, the bacteria have previously been shown to induce serum hypergastrinemia in infected individuals. The aim of this work was to assess the e...

journal_title：Cancer research

authors： Dickson JH,Grabowska A,El-Zaatari M,Atherton J,Watson SA

更新日期：2006-08-01 00:00:00

abstract：:Although initially reported as an androgen-repressed gene in the rat prostate, the functional role of testosterone-repressed prostate message-2 (TRPM-2) in apoptosis remains undefined. Inhibition of castration-induced apoptosis by calcium channel blocker treatment in androgen-dependent Shionogi tumors resulted in the ...

journal_title：Cancer research

authors： Miyake H,Nelson C,Rennie PS,Gleave ME

更新日期：2000-01-01 00:00:00

abstract：:Pancreatic ductal carcinoma is characterized by a profound chemoresistance. As we have shown previously, these tumor cells can develop chemoresistance by interleukin (IL)-1beta in an autocrine and nuclear factor-kappaB-dependent fashion. Because pancreatic ductal carcinoma contains many mesenchymal stromal cells, we f...

journal_title：Cancer research

authors： Müerköster S,Wegehenkel K,Arlt A,Witt M,Sipos B,Kruse ML,Sebens T,Klöppel G,Kalthoff H,Fölsch UR,Schäfer H

更新日期：2004-02-15 00:00:00

abstract：:A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The CYCLIN D1-TROP2 mRNA was shown to be a potent oncogene as it transforms naïve, primary cells in vitro and induces aggressive tumor growth in vivo in cooperation with activated RAS. Silencing of the chimeric mRNA inhibits the ...

journal_title：Cancer research

authors： Guerra E,Trerotola M,Dell' Arciprete R,Bonasera V,Palombo B,El-Sewedy T,Ciccimarra T,Crescenzi C,Lorenzini F,Rossi C,Vacca G,Lattanzio R,Piantelli M,Alberti S

更新日期：2008-10-01 00:00:00

abstract：:By applying a new and highly sensitive assay for measuring N-hydroxy metabolites, the biochemical properties of the microsomal N-hydroxylase from control and 3-methylcholanthrene-treated rat and hamster liver have been analyzed, and the following conclusions have been drawn. (a) Due to a difference in enzyme affinity,...

journal_title：Cancer research

authors： Razzouk C,Mercier M,Roberfroid M

更新日期：1980-10-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Hemodynamic (blood flow rate, hematocrit, hemoglobin concentration, and blood viscosity) and pH responses to glucose (6 g/kg, i.p.) injections were studied in ten Walker 256 carcinoma tumors (0.5-1.8 g) grown in the "tissue-isolated" tumor preparation. A maximum blood flow reduction of 57 +/- 19% (SD) occurred concurr...

journal_title：Cancer research

authors： Sevick EM,Jain RK

更新日期：1988-03-01 00:00:00

abstract：:Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron le...

journal_title：Cancer research

authors： Wen CP,Lee JH,Tai YP,Wen C,Wu SB,Tsai MK,Hsieh DP,Chiang HC,Hsiung CA,Hsu CY,Wu X

更新日期：2014-11-15 00:00:00

abstract：:The structure and distribution of microfilaments were examined by electron microscopy in uninfected normal rat kidney (NRK) cells, murine sarcoma virus (MSV)-transformed NRK cells, and NRK cells infected with a cold-sensitive transformation mutant of MSV, i.e., NRK (MSV-1b) cells, grown at both permissive (39 degrees)...

journal_title：Cancer research

authors： Altenburg BC,Somers K,Steiner S

更新日期：1976-01-01 00:00:00

abstract：:Glutamine supplementation has been advocated for patients requiring parenteral nutritional support. However, the direct effect of glutamine on neoplastic cells is poorly understood. We therefore investigated the effects of glutamine on the proliferation, differentiation, and cell-matrix interactions of two human colon...

journal_title：Cancer research

authors： Turowski GA,Rashid Z,Hong F,Madri JA,Basson MD

更新日期：1994-11-15 00:00:00

abstract：:This symposium was held in Trento, Italy, from June 27 to 29, 2006, and was co-chaired by Robert Weinberg and Enrico Mihich. The interactions between tumor cells and their microenvironment were discussed with particular emphasis on their molecular mechanisms. The roles of transforming growth factor beta signaling, uro...

journal_title：Cancer research

authors： Weinberg R,Mihich E

更新日期：2006-12-15 00:00:00

abstract：:Fifty-five hematopoietic cell lines, including 19 T-, 16 B-, 5 pre-B-, 5 non-T non-B-, 1 erythroid, and 9 myeloid-monocytoid cells, were screened for production of human hematopoietic survival and stem cell growth factor (SCGF) by enzyme immunoassay using anti-SCGF monoclonal antibody. The KPB-M15 myeloid cell line co...

journal_title：Cancer research

authors： Hiraoka A,Ohkubo T,Fukuda M

更新日期：1987-10-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described which allow for the rapid identification of potentially carcinogenic chemicals on a large-scale screening basis. The test is based on the biochemical quantification of [methyl-3H]thymidine incor...

journal_title：Cancer research

authors： Althaus FR,Lawrence SD,Sattler GL,Longfellow DG,Pitot HC

更新日期：1982-08-01 00:00:00

abstract：:Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

journal_title：Cancer research

authors： Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

更新日期：2008-06-15 00:00:00

abstract：:We have examined the implications of membrane-type matrix metalloproteinase (MT-MMP) for activation of the zymogen of MMP-2 (proMMP-2) in human gastric carcinoma. Northern blot analysis demonstrated exclusive expression of MT-MMP in the carcinoma tissues. Immunohistochemically, MT-MMP was colocalized in the carcinoma ...

journal_title：Cancer research

authors： Nomura H,Sato H,Seiki M,Mai M,Okada Y

更新日期：1995-08-01 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:STAT1 exists in phosphorylated (pSTAT1) and unphosphorylated (uSTAT1) forms each regulated by IFN-γ. Although STAT1 is a key mediator of the IFN-γ signaling pathway, an essential component of the host cancer immunosurveillance system, STAT1 is also overexpressed in certain human cancers where the functions of pSTAT1 a...

journal_title：Cancer research

authors： Zimmerman MA,Rahman NT,Yang D,Lahat G,Lazar AJ,Pollock RE,Lev D,Liu K

更新日期：2012-09-15 00:00:00

abstract：:This paper describes the use of the bromodeoxyuridine/propidium iodide method to assess the effects of bioactive and cytotoxic agents on the kinetic characteristics of acute myelogenous leukemia cells. By careful selection of gates, the following parameters can be measured simultaneously using only 50,000 cells: the p...

journal_title：Cancer research

authors： Preisler HD,Gopal V,Banavali SD,Finke D,Bokari SA

更新日期：1992-08-01 00:00:00

abstract：:A vitamin E derivative, vitamin E succinate (VES; RRR-alpha-tocopheryl succinate), and a vitamin E analogue, 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid (alpha-TEA), induce human breast, prostate, colon, lung, cervical, and endometrial tumor cells in culture to undergo apoptosis but ...

journal_title：Cancer research

authors： Anderson K,Simmons-Menchaca M,Lawson KA,Atkinson J,Sanders BG,Kline K

更新日期：2004-06-15 00:00:00

abstract：:Allelic loss of chromosome 18q has been noted in intestinal type gastric adenocarcinomas. Smad4 is a gene located at 18q that was recently cloned in humans and found to be significantly altered in pancreatic cancers. We sought to determine whether Smad4 genetic alterations played a significant role in gastric tumorige...

journal_title：Cancer research

authors： Powell SM,Harper JC,Hamilton SR,Robinson CR,Cummings OW

更新日期：1997-10-01 00:00:00

abstract：:The toxicity to mice of combinations of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine was investigated. The drugs were administered daily i.p. on Days 1 to 5, each drug at 10 mg/kg body weight; these dosages are small fractions of the dosages at which 10% of the treated animals died when either drug was adminis...

journal_title：Cancer research

authors： Paterson AR,Jakobs ES,Lauzon GJ,Weinstein WM

更新日期：1979-06-01 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:The human melanoma cell line NEL-M1 proliferates in Ham's F-12 medium in the absence of serum, hormones, and growth factors. Culturing NEL-M1 cells in defined medium supplemented with insulin (5 micrograms/ml) and transferrin (5 micrograms/ml) results in a 94% increase in [3H]thymidine incorporation after 24 h and a 6...

journal_title：Cancer research

authors： DiSorbo DM

更新日期：1986-08-01 00:00:00