Abstract:
:Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose. Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleoli of rat myocardial cells did not recover but underwent further fragmentation, segragation, and conversion to ring-shaped structures. The ultrastructural alterations of myocardial cell nucleoli may represent an important aspect of adriamycin toxicity.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Merski JA,Daskal I,Busch Hsubject
Has Abstractpub_date
1976-05-01 00:00:00pages
1580-4issue
5eissn
0008-5472issn
1538-7445journal_volume
36pub_type
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