Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells.

abstract：:HeLa cells were synchronized at the G1-S boundary by double thymidine block and treated for 1 hr with varying concentrations of the antibiotic anticancer protein neocarzinostatin (NCS). Cells were then released from the block and allowed to resume their cycle. Aliquots were removed at various times in order to monitor...

journal_title：Cancer research

authors： Berry DE,Collins JM

更新日期：1980-07-01 00:00:00

abstract：:The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitou...

journal_title：Cancer research

authors： Kikuchi T,Rempel SA,Rutz HP,de Tribolet N,Mulligan L,Cavenee WK,Jothy S,Leduy L,Van Meir EG

更新日期：1993-03-01 00:00:00

abstract：:N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Sub...

journal_title：Cancer research

authors： Mattammal MB,Zenser TV,Palmier MO,Davis BB

更新日期：1985-01-01 00:00:00

abstract：:Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in patients with bone cancer. Using a mouse graft model of bone sa...

journal_title：Cancer research

authors： McCaffrey G,Thompson ML,Majuta L,Fealk MN,Chartier S,Longo G,Mantyh PW

更新日期：2014-12-01 00:00:00

abstract：:Aberrant FLT3 expression and/or mutation plays a significant role in leukemogenesis. This has prompted the development of selective small molecule tyrosine kinase inhibitors against FLT3. However, like most tyrosine kinase inhibitors, those against FLT3 are not completely specific and at the doses required to complete...

journal_title：Cancer research

authors： Piloto O,Levis M,Huso D,Li Y,Li H,Wang MN,Bassi R,Balderes P,Ludwig DL,Witte L,Zhu Z,Hicklin DJ,Small D

更新日期：2005-02-15 00:00:00

abstract：:Ten aminoacyl transfer RNA's prepared from human malignant trophoblastic cells (BeWo line) were compared with the corresponding aminoacyl transfer RNA's from normal human chorionic tissue by cochromatography on a RPC-5 column. Phenylalanyl transfer RNA (Phe-tRNA) of BeWo cells had, in addition to the single species of...

journal_title：Cancer research

authors： Kuchino Y,Borek E

更新日期：1976-08-01 00:00:00

abstract：:Friend erythroleukemia cells can be induced to undergo erythroid differentiation by a variety of unrelated compounds. The fact that sodium butyrate causes reversible alterations in growth, morphology, and biochemistry in many cell systems prompted us to reexamine its pattern of induction of differentiation and to comp...

journal_title：Cancer research

authors： Friend C,Zajac-Kaye M,Holland JG,Pogo BG

更新日期：1987-01-15 00:00:00

abstract：:We have reported previously that s.c. immunization of rats with IL-4 transduced 9L gliosarcoma cells (9L-IL-4) induced a potent antitumor immunity against intracranial, parental 9L tumors. Subcutaneous implantation of 9L-IL-4 influenced the systemic humoral response, which was demonstrated by Th2-type isotype-switchin...

journal_title：Cancer research

authors： Okada H,Attanucci J,Giezeman-Smits KM,Brissette-Storkus C,Fellows WK,Gambotto A,Pollack LF,Pogue-Geile K,Lotze MT,Bozik ME,Chambers WH

更新日期：2001-03-15 00:00:00

abstract：:The Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disorder associated with immune deficiency, chromosome fragility, and increased susceptibility to lymphoid malignancies. The aim of the present study was to elucidate the potential role of the gene mutated in NBS (NBS1) in the pathogenesis and disease ...

journal_title：Cancer research

authors： Varon R,Reis A,Henze G,von Einsiedel HG,Sperling K,Seeger K

更新日期：2001-05-01 00:00:00

abstract：:Lactoperoxidase-catalyzed metabolism of N-hydroxy-N-2-fluorenylacetamide (N-OH-2-FAA) may be via one-electron oxidation to nitroxyl free radical which dismutates to equimolar N-acetoxy-N-2-fluorenylacetamide and 2-nitrosofluorene (2-NOF) and/or a Br(-)-dependent oxidative cleavage to 2-NOF. Hence, the 2-NOF:N-acetoxy-...

journal_title：Cancer research

authors： Malejka-Giganti D,Ritter CL,Decker RW,Suilman JM

更新日期：1986-12-01 00:00:00

abstract：:We have previously shown that butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis via a nonmitochondrial, Fas-mediated, extrinsic pathway. Interestingly, fermentable fiber when combined with fish oil containing docosahexaenoic acid (DHA, 22:6n-3) exhibits an enhanced ability to ...

journal_title：Cancer research

authors： Kolar SS,Barhoumi R,Lupton JR,Chapkin RS

更新日期：2007-06-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:The cell line AR230 was established from the peripheral blood mononuclear cells of a patient with chronic myeloid leukemia and t(9;22) translocation bearing a variant type of BCR/ABL rearrangement. AR230 expresses a BCR/ABL fusion protein with a molecular mass of 230 kilodaltons (kDa) due to the insertion of 180 amino...

journal_title：Cancer research

authors： Wada H,Mizutani S,Nishimura J,Usuki Y,Kohsaki M,Komai M,Kaneko H,Sakamoto S,Delia D,Kanamaru A

更新日期：1995-07-15 00:00:00

abstract：:The calcium channel blocker verapamil has been shown to reverse multidrug resistance (T. Tsuruo et al., Cancer Res. 41: 1967-1972, 1981), but the mechanism of action of this agent has not been fully elucidated. A radioactive photoactive analogue of verapamil, N-[benzoyl-3,5-3H-(+/-)-5-[(3,4-dimethoxyphenetyl)methylami...

journal_title：Cancer research

authors： Yusa K,Tsuruo T

更新日期：1989-09-15 00:00:00

abstract：:Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multip...

journal_title：Cancer research

authors： Judge SM,Deyhle MR,Neyroud D,Nosacka RL,D'Lugos AC,Cameron ME,Vohra RS,Smuder AJ,Roberts BM,Callaway CS,Underwood PW,Chrzanowski SM,Batra A,Murphy ME,Heaven JD,Walter GA,Trevino JG,Judge AR

更新日期：2020-05-01 00:00:00

abstract：:Prolactin, a pituitary hormone, exerts pleiotropic effects in various cells. These effects are mediated by a membrane receptor highly expressed in many tissues. To analyze prolactin effects on the thyroid gland, we first identified prolactin receptor (PRLR) mRNAs by in situ hybridization. To further evaluate the physi...

journal_title：Cancer research

authors： Kedzia C,Lacroix L,Ameur N,Ragot T,Kelly PA,Caillou B,Binart N

更新日期：2005-09-15 00:00:00

abstract：:The effects of cholera toxin (CT) on transforming growth factor beta 1-stimulated protooncogene expression, [gamma-35S]GTP binding, GTPase activity and growth under anchorage-independent and -dependent conditions were studied in AKR-2B fibroblast cells. CT was shown to inhibit TGF beta 1-stimulated c-sis and c-myc mRN...

journal_title：Cancer research

authors： Howe PH,Bascom CC,Cunningham MR,Leof EB

更新日期：1989-11-01 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Beta-adrenoceptors are highly expressed on SW 480 colon carcinoma cells as was assessed by flow cytometry. We investigated the influence of norepinephrine on the migration of these cells using time-lapse videomicroscopy. Norepinephrine-treatment increased the locomotor activity within the population from 25% spontaneo...

journal_title：Cancer research

authors： Masur K,Niggemann B,Zanker KS,Entschladen F

更新日期：2001-04-01 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:The pharmacological properties of garlic and its derivatives are long known, and their underling mechanisms are being extensively investigated. In this study we have addressed the effects of diallyl disulfide (DADS), an oil-soluble garlic molecule, on cell growth of neuroblastoma cell SH-SY5Y, focusing on the redox ev...

journal_title：Cancer research

authors： Filomeni G,Aquilano K,Rotilio G,Ciriolo MR

更新日期：2003-09-15 00:00:00

abstract：:miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ec...

journal_title：Cancer research

authors： Valastyan S,Chang A,Benaich N,Reinhardt F,Weinberg RA

更新日期：2010-06-15 00:00:00

abstract：:The levels of serum thymic factor(s) (STF), of Thy-1.2 positivity of splenocytes [as measured by their azathioprine (AZ) sensitivity], and of Thy-1.2-positive "spontaneous" spleen rosette-forming cells (SSRFCs), as well as the presence of infectious virus in the thymus, were assessed as a function of time after virus ...

journal_title：Cancer research

authors： Tonietti G,Rossi GB,Del Gobbo V,Accinni L,Ranucci A,Titti F,Premrov MG,Garaci E

更新日期：1983-09-01 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:DAB486IL-2, a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with interleukin-2 (IL-2), has displayed significant activity in patients with chemotherapy refractory hematological cancers. To further investigate the safety and antitumor effect of this agent, we...

journal_title：Cancer research

authors： LeMaistre CF,Craig FE,Meneghetti C,McMullin B,Parker K,Reuben J,Boldt DH,Rosenblum M,Woodworth T

更新日期：1993-09-01 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:Recent studies have proposed that tumor necrosis factor alpha (TNF-alpha) and ionizing radiation induce apoptosis by activating hydrolysis of sphingomyelin to ceramide. Bcl-2 and a related gene, Bcl-X, inhibit several forms of apoptosis. Herein, we report that internucleosomal DNA fragmentation, characteristic of apop...

journal_title：Cancer research

authors： Chen M,Quintans J,Fuks Z,Thompson C,Kufe DW,Weichselbaum RR

更新日期：1995-03-01 00:00:00

abstract：:Pregnancy, parity, and circulating steroid hormone levels are associated with risk of breast cancer, but little is known about hormone concentrations during pregnancy and subsequent breast cancer risk. We evaluated early pregnancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breas...

journal_title：Cancer research

authors： Fortner RT,Schock H,Kaaks R,Lehtinen M,Pukkala E,Lakso HÅ,Tanner M,Kallio R,Joensuu H,Grankvist K,Zeleniuch-Jacquotte A,Toniolo P,Lundin E,Surcel HM

更新日期：2014-12-01 00:00:00

abstract：:MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a β-catenin- and FRA-1-dependent ...

journal_title：Cancer research

authors： Duong HQ,Nemazanyy I,Rambow F,Tang SC,Delaunay S,Tharun L,Florin A,Büttner R,Vandaele D,Close P,Marine JC,Shostak K,Chariot A

更新日期：2018-08-15 00:00:00