Medullary thyroid carcinoma arises in the absence of prolactin signaling.

abstract：:Mouse polyclonal antibodies, raised against three regions of the human BRCA1 protein, were characterized and revealed BRCA1 as a 220-kDa nuclear phosphoprotein in normal cells. All three antisera recognize both in vitro-translated and recombinant, baculovirus-derived BRCA1, which co-migrate with BRCA1 from the human b...

journal_title：Cancer research

authors： Chen Y,Farmer AA,Chen CF,Jones DC,Chen PL,Lee WH

更新日期：1996-07-15 00:00:00

abstract：:The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated with BRCA1 deficiency. Array-based expression profiling did not identi...

journal_title：Cancer research

authors： Rottenberg S,Vollebergh MA,de Hoon B,de Ronde J,Schouten PC,Kersbergen A,Zander SA,Pajic M,Jaspers JE,Jonkers M,Lodén M,Sol W,van der Burg E,Wesseling J,Gillet JP,Gottesman MM,Gribnau J,Wessels L,Linn SC,Jonkers J,

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to evaluate the promoter methylation status and loss of heterozygosity (LOH) of the SEMA3B in non-small cell lung cancers (NSCLCs). We analyzed the methylation status of semaphorin 3B (SEMA3B) promoter and LOH at 3p21.3 in eight NSCLC cell lines and 27 primary tumors. Hypermethylation of SEMA...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Yendamuri S,Matsuyama A,Alder H,Williams NN,Kaiser LR,Croce CM

更新日期：2003-06-15 00:00:00

abstract：:Exposure of mice to total body irradiation induces nuclear factor kappaB (NFkappaB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFkappaB activation now include the newly identified site of the intestinal epithelial cells. NFkappaB activated ...

journal_title：Cancer research

authors： Wang Y,Meng A,Lang H,Brown SA,Konopa JL,Kindy MS,Schmiedt RA,Thompson JS,Zhou D

更新日期：2004-09-01 00:00:00

abstract：:Tumor infiltration with effector CD8(+) T cells (T(eff)) predicts longer recurrence-free survival in many types of human cancer, illustrating the broad significance of T(eff) for effective immunosurveillance. Colorectal tumors with reduced accumulation of T(eff) express low levels of T(eff)-attracting chemokines such ...

journal_title：Cancer research

authors： Muthuswamy R,Berk E,Junecko BF,Zeh HJ,Zureikat AH,Normolle D,Luong TM,Reinhart TA,Bartlett DL,Kalinski P

更新日期：2012-08-01 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Significant efforts are being devoted toward the development of effective therapeutic vaccines against cancer. Specifically, well-characterized subunit vaccines, which are designed to generate antitumor cytotoxic CD8 T-cell responses. Because CD4 T cells participate at various stages of CD8 T-cell responses, it is imp...

journal_title：Cancer research

authors： Assudani D,Cho HI,DeVito N,Bradley N,Celis E

更新日期：2008-12-01 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00

abstract：:Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing...

journal_title：Cancer research

authors： Emmink BL,Laoukili J,Kipp AP,Koster J,Govaert KM,Fatrai S,Verheem A,Steller EJ,Brigelius-Flohé R,Jimenez CR,Borel Rinkes IH,Kranenburg O

更新日期：2014-11-15 00:00:00

abstract：:WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

journal_title：Cancer research

authors： Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

更新日期：1997-04-15 00:00:00

abstract：:Currently, no curative therapy for metastatic prostate cancer exists. Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine. Therefore, the aim of our st...

journal_title：Cancer research

authors： Spitzweg C,Zhang S,Bergert ER,Castro MR,McIver B,Heufelder AE,Tindall DJ,Young CY,Morris JC

更新日期：1999-05-01 00:00:00

abstract：:Tumor cell survival relies upon adaptation to the acidic conditions of the tumor microenvironment. To investigate potential acidosis survival mechanisms, we examined the effect of low pH (6.7) on human breast carcinoma cells. Acute low pH exposure reduced proliferation rate, induced a G1 cell cycle arrest, and increas...

journal_title：Cancer research

authors： Wojtkowiak JW,Rothberg JM,Kumar V,Schramm KJ,Haller E,Proemsey JB,Lloyd MC,Sloane BF,Gillies RJ

更新日期：2012-08-15 00:00:00

abstract：:Gene-encoded host defense peptides are used as part of the innate immunity, and many of them act by directly lysing the cell membrane of the pathogen. A few of these peptides showed anticancer activity in vitro but could not be used in vivo because of their inactivation by serum. We designed a 15-amino acid peptide, c...

journal_title：Cancer research

authors： Papo N,Braunstein A,Eshhar Z,Shai Y

更新日期：2004-08-15 00:00:00

abstract：:p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located at 9p21, which is a frequent site of allelic loss in various types of tumors. Twenty-five primary biliary tract cancers were examined for somatic mu...

journal_title：Cancer research

authors： Yoshida S,Todoroki T,Ichikawa Y,Hanai S,Suzuki H,Hori M,Fukao K,Miwa M,Uchida K

更新日期：1995-07-01 00:00:00

abstract：:Melanoma incidence is increasing worldwide, and metastatic melanoma is almost completely resistant to every known therapy. New approaches to treating melanoma are urgently needed, and a greater understanding of the biology of melanoma invasion and metastasis will aid in their creation. A high proportion of invasive me...

journal_title：Cancer research

authors： Blackburn JS,Rhodes CH,Coon CI,Brinckerhoff CE

更新日期：2007-11-15 00:00:00

abstract：:L1210 murine leukemia cells were treated in vitro with the novel antineoplastic agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one (M&B 39565), and its interaction with cellular DNA was assessed by alkaline elution. DNA interstrand cross-link and DNA-protein cross-link formation was quantifi...

journal_title：Cancer research

authors： Gibson NW,Erickson LC,Hickman JA

更新日期：1984-05-01 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:Feeding efficiency (amount of food ingested per unit of feeding activity) was chronically depressed in male Sprague-Dawley rats recovered from the acute aphagia or hypophagia of lateral hypothalamic damage. The extent of depression varied with the severity of the acute feeding response to hypothalamic damage. Growth o...

journal_title：Cancer research

authors： Morrison SD

更新日期：1981-05-01 00:00:00

abstract：:The interleukin-11 receptor alpha (IL-11Ralpha) is a functional target in bone metastasis. However, its role in primary bone tumors has not been established. As such, here, we evaluated IL-11Ralpha as a candidate target in primary and metastatic human osteosarcoma. First, in an orthotopic mouse model, we showed that I...

journal_title：Cancer research

authors： Lewis VO,Ozawa MG,Deavers MT,Wang G,Shintani T,Arap W,Pasqualini R

更新日期：2009-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) clinical results are promising; however, tumor recurrences can occur and, therefore, methods for improving treatment efficacy are needed. PDT elicits direct tumor cell death and microvascular injury as well as expression of angiogenic, inflammatory, and prosurvival molecules. Preclinical stu...

journal_title：Cancer research

authors： Ferrario A,Chantrain CF,von Tiehl K,Buckley S,Rucker N,Shalinsky DR,Shimada H,DeClerck YA,Gomer CJ

更新日期：2004-04-01 00:00:00

abstract：:Primary melanocytes attach poorly to collagen type IV and laminin, in contrast to their firm attachment to collagen type I/III and fibronectin [Gilchrest et al., In vitro (Rockville), 21: 114-120, 1985]. We have now found that metastatic B16 melanoma cells attach well to collagen type IV, laminin, vitronectin, and fib...

journal_title：Cancer research

authors： Rieber M,Gross A,Rieber MS

更新日期：1987-10-01 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00

abstract：:Cancer cells often fail to respond to stimuli that normally activate their intrinsic apoptotic machinery. Moreover, they are able to adapt to hypoxia by changing their glycolytic rate. Pyruvate kinase (PK) is a rate-limiting enzyme in glycolysis that is converted to a less active dimer form of PKM2 isoenzyme during on...

journal_title：Cancer research

authors： Steták A,Veress R,Ovádi J,Csermely P,Kéri G,Ullrich A

更新日期：2007-02-15 00:00:00

abstract：:The metabolism and mutagenic activation of the model carcinogens benzo(a)pyrene [B(a)P] and 2-acetylaminofluorene (AAF) by human and rat kidney cells were measured. A slicing technique followed by enzyme digestion was utilized to obtain the kidney cells. Although levels of total metabolism of B(a)P by rat and human ki...

journal_title：Cancer research

authors： Rudo KM,Dauterman WC,Langenbach R

更新日期：1989-03-01 00:00:00

abstract：:In a study of human breast carcinomas in short-term organ culture, in which plasminogen activator modulation by estrogen was used as a test of estrogen sensitivity (R. Mira-y-Lopez and L. Ossowski, Cancer Res., 47: 3558-3564, 1987), we found that the number of estrogen and progesterone receptor-positive cancers showin...

journal_title：Cancer research

authors： Mira-y-Lopez R,Ossowski L

更新日期：1990-01-01 00:00:00

abstract：:Cigarette smoke contains low levels of agonists for the aryl hydrocarbon receptor (AhR; also called the dioxin receptor). However, little is understood about the whole potential of cigarette smoke for activating AhR. In this report, we evaluated the total "dioxin-like" activity of cigarette smoke using in vitro and in...

journal_title：Cancer research

authors： Kasai A,Hiramatsu N,Hayakawa K,Yao J,Maeda S,Kitamura M

更新日期：2006-07-15 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been stu...

journal_title：Cancer research

authors： Townsend PA,Cutress RI,Sharp A,Brimmell M,Packham G

更新日期：2003-07-15 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00