Abstract：
:Mouse polyclonal antibodies, raised against three regions of the human BRCA1 protein, were characterized and revealed BRCA1 as a 220-kDa nuclear phosphoprotein in normal cells. All three antisera recognize both in vitro-translated and recombinant, baculovirus-derived BRCA1, which co-migrate with BRCA1 from the human breast epithelia cell line, HBL100. BRCA1 expression and phosphorylation are shown to be cell cycle dependent, with greatest expression and phosphorylation occurring in S and M phases. Cyclin-dependent kinase 2 and other kinases associated with cyclins D and A are shown to bind to and phosphorylate BRCA1, suggesting that the biological activity of BRCA1 may be regulated by cyclin-dependent kinases.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Chen Y,Farmer AA,Chen CF,Jones DC,Chen PL,Lee WHsubject
Has Abstractpub_date
1996-07-15 00:00:00pages
3168-72issue
14eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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