Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells.

abstract：:Human cancer cells maintain telomeres by telomerase activity (TA) or by alternative lengthening of telomeres (ALT). We proposed to define the prevalence of the two telomere maintenance mechanisms (TMM), to assess their association with histology, and to compare their prognostic relevance in a series of 93 patients wit...

journal_title：Cancer research

authors： Costa A,Daidone MG,Daprai L,Villa R,Cantù S,Pilotti S,Mariani L,Gronchi A,Henson JD,Reddel RR,Zaffaroni N

更新日期：2006-09-01 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:Up-regulation of vascular endothelial growth factor (VEGF) expression is a major event leading to neovascularization in malignant gliomas. Hypoxia is believed to be the crucial environmental stimulus for this up-regulation. To critically assess this hypothesis, we asked whether the mechanisms defined previously for hy...

journal_title：Cancer research

authors： Damert A,Machein M,Breier G,Fujita MQ,Hanahan D,Risau W,Plate KH

更新日期：1997-09-01 00:00:00

abstract：:2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A) is a new deoxyadenosine analogue that is resistant to phosphorolytic cleavage and deamination. Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) i...

journal_title：Cancer research

authors： Xie C,Plunkett W

更新日期：1995-07-01 00:00:00

abstract：:Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

journal_title：Cancer research

authors： Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

更新日期：2010-10-15 00:00:00

abstract：:The effects of N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)-phenylamino-4- acridinecarboxamide (CI-921; NSC 343499), a lipophilic and water-soluble derivative of amsacrine (NSC 249992), on cell viability, growth, clonogenicity, and progression through the cell cycle were investigated in suspension cultures of Frie...

journal_title：Cancer research

authors： Traganos F,Bueti C,Darzynkiewicz Z,Melamed MR

更新日期：1987-01-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed ...

journal_title：Cancer research

authors： MacFarlane M,Kohlhaas SL,Sutcliffe MJ,Dyer MJ,Cohen GM

更新日期：2005-12-15 00:00:00

abstract：:The growth of solid tumors and the formation of metastases are dependent on neoangiogenesis. One of the most important factors in inducing the formation of new blood vessels is the vascular endothelial growth factor (VEGF), which acts specifically on endothelial cells. VEGF is expressed and secreted by almost all soli...

journal_title：Cancer research

authors： Barleon B,Siemeister G,Martiny-Baron G,Weindel K,Herzog C,Marmé D

更新日期：1997-12-01 00:00:00

abstract：:An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the...

journal_title：Cancer research

authors： Kennedy BF,McLaughlin RA,Kennedy KM,Chin L,Wijesinghe P,Curatolo A,Tien A,Ronald M,Latham B,Saunders CM,Sampson DD

更新日期：2015-08-15 00:00:00

abstract：:The metastasizing MDAY-D2 tumor of DBA/2 mice disseminates in BALB/c allogeneic athymic nude (nu/nu) mice in a manner identical to that observed in the syngeneic host. Both the kinetics and organ distribution pattern of metastases from s.c. implants of MDAY-D2 are routinely predictable at any given tumor dose. BALB/c ...

journal_title：Cancer research

authors： Wiltrout RH,Frost P,Morrison MK,Kerbel RS

更新日期：1979-10-01 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and cont...

journal_title：Cancer research

authors： Serra V,Markman B,Scaltriti M,Eichhorn PJ,Valero V,Guzman M,Botero ML,Llonch E,Atzori F,Di Cosimo S,Maira M,Garcia-Echeverria C,Parra JL,Arribas J,Baselga J

更新日期：2008-10-01 00:00:00

abstract：:Members of the phosphatidylinositol 3-kinase-related kinase family, in particular the ataxia-telangiectasia mutated (ATM) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), regulate cellular responses to DNA double-strand breaks. Increased sensitivity to ionizing radiation (IR) in DNA-PKc...

journal_title：Cancer research

authors： Arlander SJ,Greene BT,Innes CL,Paules RS

更新日期：2008-01-01 00:00:00

abstract：:High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and significant chemoresistance, resulting in a recurrent phenotype that makes them impossible to eradicate in the long term. Targeting protumoral signals in the glioma microenvironment could have significant impact against tumor cell...

journal_title：Cancer research

authors： Nandhu MS,Hu B,Cole SE,Erdreich-Epstein A,Rodriguez-Gil DJ,Viapiano MS

更新日期：2014-10-01 00:00:00

abstract：:An extremely rapid blood clearance rate of murine IgG2a antibodies was found in all strains tested of outbred Swiss nu/nu mice, including mice from the major commercial suppliers. The clearance half-life was less than 5 h, in comparison to a 4-5-day half-life in BALB/c mice. Therefore, most of the IgG2a antibody injec...

journal_title：Cancer research

authors： Sharkey RM,Natale A,Goldenberg DM,Mattes MJ

更新日期：1991-06-15 00:00:00

abstract：:Tumor hypoxia is associated with resistance to antiangiogenic therapy and poor prognosis. The Siah E3 ubiquitin ligases regulate the hypoxic response pathway by modulating the turnover of the master proangiogenic transcription factor hypoxia-inducible factor-1α (Hif-1α). In this study, we show that genetic deficiency ...

journal_title：Cancer research

authors： Wong CS,Sceneay J,House CM,Halse HM,Liu MC,George J,Hunnam TC,Parker BS,Haviv I,Ronai Z,Cullinane C,Bowtell DD,Möller A

更新日期：2012-04-01 00:00:00

abstract：:A putative tumor suppressor gene, p53, has been shown to be altered in a variety of human tumor types. The primary mechanism of p53 inactivation is believed to be mutation of one allele followed by loss of the second allele. Malignant mesothelioma is a tumor that has been highly associated with exposure to asbestos fi...

journal_title：Cancer research

authors： Cote RJ,Jhanwar SC,Novick S,Pellicer A

更新日期：1991-10-01 00:00:00

abstract：:Human hepatoma cells, HuH-6 Cl-5, were treated with 12-O-tetradecanoylphorbol-13-acetate at concentrations of 1 ng/ml to 10 micrograms/ml for 6 h in the presence of [35S]methionine. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the labeled proteins secreted into the medium showed that this t...

journal_title：Cancer research

authors： Yoneda Y,Fujiki H,Moore RE,Uchida T

更新日期：1985-05-01 00:00:00

abstract：:We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucida...

journal_title：Cancer research

authors： Harrison H,Farnie G,Brennan KR,Clarke RB

更新日期：2010-11-15 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:We studied N-myc RNA by in situ hybridization and S1 nuclease protection analysis in human fetal cerebrum, retina, lung, liver, and placenta during the second trimester. High levels of N-myc RNA were found in the early fetal cerebral germinal layer and the primordial cortex, with lower levels in the intermediate layer...

journal_title：Cancer research

authors： Grady EF,Schwab M,Rosenau W

更新日期：1987-06-01 00:00:00

abstract：:We have evaluated immunohistochemical characteristics of tumors and the infiltrating cells in patients treated with various immunotherapy regimens. Forty-eight patients with advanced malignancies were treated with high dose i.v. recombinant interleukin-2 alone or in combination with cyclophosphamide, recombinant tumor...

journal_title：Cancer research

authors： Rubin JT,Elwood LJ,Rosenberg SA,Lotze MT

更新日期：1989-12-15 00:00:00

abstract：:Some of the possible mechanisms by which polyethylene glycol (PEG) augments the ability of MOPC-315 tumor bearer spleen cells to mediate in vitro antitumor cytotoxicity were evaluated. The level of antitumor cytotoxicity obtained in 5-day cultures of tumor bearer spleen cell suspensions correlated inversely with the p...

journal_title：Cancer research

authors： Mokyr MB,Przepiorka D,Dray S

更新日期：1982-07-01 00:00:00

abstract：:The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorous...

journal_title：Cancer research

authors： Chen F,Castranova V

更新日期：2007-12-01 00:00:00

abstract：:Chemotherapy is an important treatment for ovarian cancer. However, conventional chemotherapy has inevitable drawbacks due to side effects from nonspecific biodistribution of the chemotherapeutic drugs. To solve such problem, targeted delivery approaches were developed. The targeted delivery approaches combine drug ca...

journal_title：Cancer research

authors： Zhang XY,Chen J,Zheng YF,Gao XL,Kang Y,Liu JC,Cheng MJ,Sun H,Xu CJ

更新日期：2009-08-15 00:00:00

abstract：:Serially cultivated keratinocytes of human and rat epidermis and esophagus were compared with respect to their sensitivity to toxic effects of 3-methylcholanthrene and ability to metabolize benzo(a)pyrene. 3-Methylcholanthrene was highly toxic to the human keratinocytes and to early-passage rat epidermal keratinocytes...

journal_title：Cancer research

authors： Heimann R,Rice RH

更新日期：1983-10-01 00:00:00

abstract：:To test the hypothesis that genetic instability correlates with malignant potential, we compared the rate of generation of marker chromosomal abnormalities in clones of B16 F1 and B16 F10 murine melanoma. These rates were estimated through an adaptation of fluctuation analysis of Luria and Delbruck (S. E. Luria and M....

journal_title：Cancer research

authors： Kendal WS,Wang RY,Hsu TC,Frost P

更新日期：1987-07-15 00:00:00

abstract：:Despite considerable efforts to improve early detection of ovarian cancer, the majority of women at time of diagnosis will have metastatic disease. Understanding and targeting the molecular underpinnings of metastasis continues to be the principal challenge in the clinical management of ovarian cancer. Whereas the mul...

journal_title：Cancer research

authors： Hickson JA,Huo D,Vander Griend DJ,Lin A,Rinker-Schaeffer CW,Yamada SD

更新日期：2006-02-15 00:00:00

abstract：:Treatment of male rats with the anticancer drug cisplatin leads to feminization of the profile of cytochrome P-450 and other microsomal enzymes involved in steroid hormone and drug metabolism (G.A. LeBlanc, and D.J. Waxman, J. Biol. Chem., 263: 15732-15739, 1988). The present study uses the rat model to evaluate the d...

journal_title：Cancer research

authors： LeBlanc GA,Sundseth SS,Weber GF,Waxman DJ

更新日期：1992-02-01 00:00:00

abstract：:Certain human tumors are extensively infiltrated by eosinophils and contain extracellular deposits of eosinophil peroxidase, which uses hydrogen peroxide as a substrate to produce highly toxic hypohalous acids. We hypothesized that J558L HI, an interleukin 5-transfected murine plasmacytoma that is infiltrated by numer...

journal_title：Cancer research

authors： Samoszuk MK,Wimley WC,Nguyen V

更新日期：1996-01-01 00:00:00