Abstract:
:The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Chen F,Castranova Vdoi
10.1158/0008-5472.CAN-07-1576subject
Has Abstractpub_date
2007-12-01 00:00:00pages
11093-8issue
23eissn
0008-5472issn
1538-7445pii
67/23/11093journal_volume
67pub_type
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