Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression.

abstract：:Identification of human melanoma-associated peptide antigens for CTLs has opened unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide. We have shown that immunization with a MAGE-1 gene encoded nonapeptide (EADPT-GHSY)-pulsed autologous antigen presenting cell-based vaccine...

journal_title：Cancer research

authors： Hu X,Chakraborty NG,Sporn JR,Kurtzman SH,Ergin MT,Mukherji B

更新日期：1996-06-01 00:00:00

abstract：:A novel metastasis-associated gene was identified with a differential display system in murine carcinoma cells showing a high rate of metastasis to the liver. A human homologue was also identified using a PCR-based strategy. The protein coded by this gene was named cystatin-like metastasis-associated protein (CMAP) an...

journal_title：Cancer research

authors： Morita M,Yoshiuchi N,Arakawa H,Nishimura S

更新日期：1999-01-01 00:00:00

abstract：:The Salmonella-microsome assay for mutagenesis was used to determine the effect of ozone on the mutagenesis of selected carcinogens and mutagens in water. Short periods of ozonation were shown to completely inactivate the mutagenicity of several polyaromatic amine mutagens including acriflavine, proflavine, and beta-n...

journal_title：Cancer research

authors： Burleson GR,Caulfield MJ,Pollard M

更新日期：1979-06-01 00:00:00

abstract：:Cancer stem-like cells (CSC) may be critical to maintain the malignant behavior of solid and hematopoietic cancers. Recently, patients with endometrial cancer whose tumors expressed high levels of aldehyde dehydrogenase (ALDH), a detoxifying enzyme characteristic of many progenitor and stem cells, exhibited a relative...

journal_title：Cancer research

authors： van der Zee M,Sacchetti A,Cansoy M,Joosten R,Teeuwssen M,Heijmans-Antonissen C,Ewing-Graham PC,Burger CW,Blok LJ,Fodde R

更新日期：2015-09-01 00:00:00

abstract：:Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alteration in follicular lymphoma. The result is the deregulated expression of bcl-2 and increased resistance to cell death. Regulation of the immunoglobulin heavy chain gene is controlled in part by four DNase I-hypersensitive r...

journal_title：Cancer research

authors： Heckman CA,Cao T,Somsouk L,Duan H,Mehew JW,Zhang CY,Boxer LM

更新日期：2003-10-15 00:00:00

abstract：:Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic...

journal_title：Cancer research

authors： Shintani S,Matsuo K,Crohin CC,McBride J,Tsuji T,Donoff RB,Posner M,Todd R,Wong DT

更新日期：1999-08-15 00:00:00

abstract：:Batracylin (8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one; NSC320846) is an investigational clinical anticancer agent. Previous animal studies showed activity against solid tumors and Adriamycin-resistant leukemia. We initially sought to test the proposed Top2-mediated DNA cleavage activity of batracylin and identify...

journal_title：Cancer research

authors： Rao VA,Agama K,Holbeck S,Pommier Y

更新日期：2007-10-15 00:00:00

abstract：:CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several experimental tumors in vivo and a broad spectrum of human tumor cells in vitro. This report describes its biological and biochemical effects of L1210 leukemia cells. CC-1065 is one of the most cytotoxic agents known. The concentr...

journal_title：Cancer research

authors： Li LH,Swenson DH,Schpok SL,Kuentzel SL,Dayton BD,Krueger WC

更新日期：1982-03-01 00:00:00

abstract：:Prostate carcinoma is the most commonly diagnosed cancer in men and the second leading cause of death due to cancer in Western civilization. Androgen ablation therapy is effective in treating androgen-dependent tumors, but eventually, androgen-independent tumors recur and are refractory to conventional chemotherapeuti...

journal_title：Cancer research

authors： Libertini SJ,Tepper CG,Rodriguez V,Asmuth DM,Kung HJ,Mudryj M

更新日期：2007-10-01 00:00:00

abstract：:Knockout and expression studies suggest that estrogen receptor beta (ERbeta) plays a prominent role in ovarian function and pathology. Moreover, ovarian cancers are characterized by high morbidity and low responsiveness to anti-estrogens. Here we demonstrate, using quantitative PCR to measure ERalpha and ERbeta levels...

journal_title：Cancer research

authors： Bardin A,Hoffmann P,Boulle N,Katsaros D,Vignon F,Pujol P,Lazennec G

更新日期：2004-08-15 00:00:00

abstract：:Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described i...

journal_title：Cancer research

authors： Gu G,Yuan J,Wills M,Kasper S

更新日期：2007-05-15 00:00:00

abstract：:We developed a novel orthotopic mouse tumor model of renal cell carcinoma to collect and characterize cells spontaneously shed from SN12C (renal cell carcinoma) and SN12L1 (high metastatic variant of SN12C) tumors grown in kidneys of severe combined immunodeficient mice. Viability of the shed cell population was great...

journal_title：Cancer research

authors： Bockhorn M,Roberge S,Sousa C,Jain RK,Munn LL

更新日期：2004-04-01 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:2'-Fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine (FIAC) is a potent selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella zoster virus, and cytomegalovirus in cell culture systems. FIAC produces an unequivocal therapeutic effect in mice that have been inoculated with ...

journal_title：Cancer research

authors： Young CW,Schneider R,Leyland-Jones B,Armstrong D,Tan CT,Lopez C,Watanabe KA,Fox JJ,Philips FS

更新日期：1983-10-01 00:00:00

abstract：:Several reports have suggested that a decrease or absence of adenosine deaminase complexing protein (ADCP) is consistently associated with cancer. However, in other studies, decreased as well as increased ADCP levels were found. In the present study, we investigated ADCP levels in 37 colorectal adenocarcinomas and cor...

journal_title：Cancer research

authors： ten Kate J,Wijnen JT,van der Goes RG,Quadt R,Griffioen G,Bosman FT,Khan PM

更新日期：1984-10-01 00:00:00

abstract：:Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 1...

journal_title：Cancer research

authors： Giacomini CP,Leung SY,Chen X,Yuen ST,Kim YH,Bair E,Pollack JR

更新日期：2005-10-15 00:00:00

abstract：:Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

journal_title：Cancer research

authors： Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

更新日期：1981-07-01 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is found at low levels on nontransformed adult breast epithelial cells but is frequently overexpressed on aggressive breast cancer cells. Recent studies have documented an inverse relationship between EphA2 and estrogen receptor expression in breast cancer cell lines. In our present ...

journal_title：Cancer research

authors： Lu M,Miller KD,Gokmen-Polar Y,Jeng MH,Kinch MS

更新日期：2003-06-15 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:Anticancer vaccine strategies can now target intracellular antigens that are involved in the process of malignant transformation, such as oncogene products or mutated tumor suppressor genes. Fragments of these antigens, generally 8-10 amino acids in length and complexed with MHC class I molecules, can be recognized by...

journal_title：Cancer research

authors： McCabe BJ,Irvine KR,Nishimura MI,Yang JC,Spiess PJ,Shulman EP,Rosenberg SA,Restifo NP

更新日期：1995-04-15 00:00:00

abstract：:The tumorigenicities of 7-methylbenz[c]acridine (7MB[c]ACR) and its five metabolically possible trans-dihydrodiols were determined in two mouse tumor models. In initiation-promotion studies on mouse skin, a single topical application of 0.15 to 0.75 mumol of compound was followed 9 days later by twice weekly applicati...

journal_title：Cancer research

authors： Chang RL,Levin W,Wood AW,Shirai N,Ryan AJ,Duke CC,Jerina DM,Holder GM,Conney AH

更新日期：1986-09-01 00:00:00

abstract：:Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all ...

journal_title：Cancer research

authors： Kimple RJ,Smith MA,Blitzer GC,Torres AD,Martin JA,Yang RZ,Peet CR,Lorenz LD,Nickel KP,Klingelhutz AJ,Lambert PF,Harari PM

更新日期：2013-08-01 00:00:00

abstract：:Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this ...

journal_title：Cancer research

authors： Lee HS,Lee NC,Kouprina N,Kim JH,Kagansky A,Bates S,Trepel JB,Pommier Y,Sackett D,Larionov V

更新日期：2016-02-15 00:00:00

abstract：:Because efficient i.v. administration of interleukin 2 (IL-2) in tumor patients leads to severe cardiopulmonary side effects, we developed a new form of IL-2 application that allows activation of all IL-2-responsive immune cells directly at the tumor site. In five patients with T4N0M0 transitional cell carcinoma of th...

journal_title：Cancer research

authors： Huland E,Huland H

更新日期：1989-10-01 00:00:00

abstract：:Mutated ras genes are powerful transforming agents in vitro and are found in a wide variety of human tumors in vivo. We characterized the histopathology and p21 protein expression associated with tumorigenesis in line 69 transgenic mice carrying an activated, human c-Ha-ras gene on the Y-chromosome (A. C. Andres, C. A...

journal_title：Cancer research

authors： Nielsen LL,Discafani CM,Gurnani M,Tyler RD

更新日期：1991-07-15 00:00:00

abstract：:The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defining characterist...

journal_title：Cancer research

authors： Harris MA,Yang H,Low BE,Mukherjee J,Guha A,Bronson RT,Shultz LD,Israel MA,Yun K

更新日期：2008-12-15 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:The murine monoclonal antibodies TURP-27 and HNK-1 have been shown to detect antigens which are heavily expressed by benign prostatic hyperplasia and carcinoma of the prostate. Western blot analysis of prostate extracts showed that monoclonal antibodies TURP-27 and HNK-1 bound glycoproteins with molecular weights of 1...

journal_title：Cancer research

authors： Lipford GB,Wright GL Jr

更新日期：1991-05-01 00:00:00

abstract：:Prostate cancer biology varies from locally confined tumors with low risk for relapse to tumors with high risk for progression even after radical prostatectomy. Currently, there are no reliable biomarkers to predict tumor relapse and poor clinical outcome. In this study, we correlated expression patterns of the androg...

journal_title：Cancer research

authors： Kahl P,Gullotti L,Heukamp LC,Wolf S,Friedrichs N,Vorreuther R,Solleder G,Bastian PJ,Ellinger J,Metzger E,Schüle R,Buettner R

更新日期：2006-12-01 00:00:00

abstract：:The effects of the triparanol analogues chlorotrianisene, clomiphene, tamoxifen, 5-[p-(fluoren-9-ylidenemethyl)phenyl]-2-piperidineethanol (MDL 10393), MDL 8917v, nafoxidine, 2-[p-(6-methoxy-2-phenylinden-3-yl)phenoxy]triethylamine (U-11555A), 2-[p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]triethylamine (U-10...

journal_title：Cancer research

authors： Ramu A,Glaubiger D,Fuks Z

更新日期：1984-10-01 00:00:00