Enhancement of cytolytic T lymphocyte precursor frequency in melanoma patients following immunization with the MAGE-1 peptide loaded antigen presenting cell-based vaccine.

abstract：:Several metabolic processes, such as DNA organization and replication, transcription, and RNA processing are closely associated with the nuclear matrix. Nuclear matrix attachment regions are nucleotide sequences holding DNA tightly complexed with the nuclear scaffold and are resistant to extractions with detergents an...

journal_title：Cancer research

authors： Brylawski BP,Tsongalis GJ,Cordeiro-Stone M,May WT,Comeau LD,Kaufman DG

更新日期：1993-09-01 00:00:00

abstract：:The effect of basic fibroblast growth factor (b-FGF), one of the commonest angiogenic factors in various cancer types, on lymphocyte adhesion and transmigration across the endothelial cell monolayer was investigated using human umbilical vein-derived endothelial cells (HUVEC) and type I collagen gel. Forty-eight h exp...

journal_title：Cancer research

authors： Kitayama J,Nagawa H,Yasuhara H,Tsuno N,Kimura W,Shibata Y,Muto T

更新日期：1994-09-01 00:00:00

abstract：:The tumor suppressor protein BRCA1 localizes to sites of DNA double-strand breaks (DSB), promoting repair by homologous recombination through the recruitment of DNA damage repair proteins. In normal cells, homologous recombination largely depends on BRCA1. However, assembly of the pivotal homologous recombination regu...

journal_title：Cancer research

authors： Nakada S,Yonamine RM,Matsuo K

更新日期：2012-10-01 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases...

journal_title：Cancer research

authors： Burnett-Hartman AN,Newcomb PA,Potter JD,Passarelli MN,Phipps AI,Wurscher MA,Grady WM,Zhu LC,Upton MP,Makar KW

更新日期：2013-05-01 00:00:00

abstract：:A correlation exists between the ability of tumor cells to aggregate platelets and their tendency to metastasize. Tumor cell-induced platelet aggregation (TCIPA) facilitates the embolization of the vasculature with tumor cells and the formation of metastatic foci. It is well documented that matrix metalloproteinases (...

journal_title：Cancer research

authors： Jurasz P,Sawicki G,Duszyk M,Sawicka J,Miranda C,Mayers I,Radomski MW

更新日期：2001-01-01 00:00:00

abstract：:Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in patients with bone cancer. Using a mouse graft model of bone sa...

journal_title：Cancer research

authors： McCaffrey G,Thompson ML,Majuta L,Fealk MN,Chartier S,Longo G,Mantyh PW

更新日期：2014-12-01 00:00:00

abstract：:Actinomycin D produces changes in the cell cycle kinetics of Chinese hamster (HA1) and mouse mammary tumor cells (EMT6) cultivated in vitro. There was a reduced rate of progression of the cells through S phase and a G2 arrest, the duration and degree of which were drug dose dependent. The lethal effects of the drug on...

journal_title：Cancer research

authors： Roots R,Smith KC

更新日期：1976-10-01 00:00:00

abstract：:Cell signaling plays a central role in the etiology of cancer. Numerous therapeutics in use or under development target signaling proteins; however, off-target effects often limit assignment of positive clinical response to the intended target. As direct measurements of signaling protein activity are not generally fea...

journal_title：Cancer research

authors： Ochs MF,Rink L,Tarn C,Mburu S,Taguchi T,Eisenberg B,Godwin AK

更新日期：2009-12-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has been shown to induce apoptosis specifically in cancer cells while sparing normal tissues. Unfortunately not all cancer cells respond to TRAIL; therefore, TRAIL sensitizing agents are currently being explored. We have identified synthetic trit...

journal_title：Cancer research

authors： Hyer ML,Croxton R,Krajewska M,Krajewski S,Kress CL,Lu M,Suh N,Sporn MB,Cryns VL,Zapata JM,Reed JC

更新日期：2005-06-01 00:00:00

abstract：:Matrix metalloproteinases have been traditionally linked to cancer dissemination through their ability to degrade most extracellular matrix components, thus facilitating invasion and metastasis of tumor cells. However, recent functional studies have revealed that some metalloproteases, including several members of the...

journal_title：Cancer research

authors： Viloria CG,Obaya AJ,Moncada-Pazos A,Llamazares M,Astudillo A,Capellá G,Cal S,López-Otín C

更新日期：2009-06-01 00:00:00

abstract：:To assess whether CYP3A4 and CYP3A7 have a similar capacity to activate carcinogenic mycotoxins, we established cell lines stably expressing human CYP3A4 and CYP3A7, which are adult- and fetal-specific forms of cytochrome P450 in human livers, respectively. Each cDNA was introduced into CR-119 cells which had been est...

journal_title：Cancer research

authors： Hashimoto H,Nakagawa T,Yokoi T,Sawada M,Itoh S,Kamataki T

更新日期：1995-02-15 00:00:00

abstract：:The endocrine status of 49 premenopausal women taking tamoxifen after completion of adjuvant chemotherapy for breast cancer was determined by radioimmunoassay from serial blood samples. Of these 49 women, 7 had regular menses, 14 had irregular menses, 23 were amenorrheic, and 5 had undergone hysterectomies. A group of...

journal_title：Cancer research

authors： Ravdin PM,Fritz NF,Tormey DC,Jordan VC

更新日期：1988-02-15 00:00:00

abstract：:Cytotoxic T lymphocytes can lyse Fc receptor-bearing target cells in vitro in the presence of anti-CD3 antibodies. This "redirected" lysis is not restricted by major histocompatibility antigens nor does it require nominal antigen recognition by the CTL. The efficacy of redirected lysis in vivo was assessed by comparin...

journal_title：Cancer research

authors： Usuba O,Ito M,Bona CA,Moran TM

更新日期：1990-09-15 00:00:00

abstract：:Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor development and metastatic progression. In particular, TNF-α promotes cancer invasion and angiogenesis associated with epithelial-mesenchymal transition (EMT); however, the mechanisms underlying its induction of EMT in cancer cells remai...

journal_title：Cancer research

authors： Li CW,Xia W,Huo L,Lim SO,Wu Y,Hsu JL,Chao CH,Yamaguchi H,Yang NK,Ding Q,Wang Y,Lai YJ,LaBaff AM,Wu TJ,Lin BR,Yang MH,Hortobagyi GN,Hung MC

更新日期：2012-03-01 00:00:00

abstract：:Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In...

journal_title：Cancer research

authors： Hakim F,Wang Y,Zhang SX,Zheng J,Yolcu ES,Carreras A,Khalyfa A,Shirwan H,Almendros I,Gozal D

更新日期：2014-03-01 00:00:00

abstract：:The main objective of the present study was to sequentially analyze growth and morphological characteristics of aberrant crypt foci (ACF) in the rat colon. Sprague-Dawley rats were given a single injection of a carcinogenic dose of 1,2-dimethylhydrazine-HCl and at varying time points ranging from 2 to 57 weeks, groups...

journal_title：Cancer research

authors： McLellan EA,Medline A,Bird RP

更新日期：1991-10-01 00:00:00

abstract：:We examined the role of constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer susceptibility. The UGT1A1 enzyme is a major UGT involved in estradiol glucuronidation. To date, four UGT1A1 variant alleles characterized by a variation in the number of TA from five through ei...

journal_title：Cancer research

authors： Guillemette C,Millikan RC,Newman B,Housman DE

更新日期：2000-02-15 00:00:00

abstract：:2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A) is a new deoxyadenosine analogue that is resistant to phosphorolytic cleavage and deamination. Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) i...

journal_title：Cancer research

authors： Xie C,Plunkett W

更新日期：1995-07-01 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the...

journal_title：Cancer research

authors： Li Y,Nichols MA,Shay JW,Xiong Y

更新日期：1994-12-01 00:00:00

abstract：:Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 1...

journal_title：Cancer research

authors： Giacomini CP,Leung SY,Chen X,Yuen ST,Kim YH,Bair E,Pollack JR

更新日期：2005-10-15 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular pr...

journal_title：Cancer research

authors： Miura K,Bowman ED,Simon R,Peng AC,Robles AI,Jones RT,Katagiri T,He P,Mizukami H,Charboneau L,Kikuchi T,Liotta LA,Nakamura Y,Harris CC

更新日期：2002-06-01 00:00:00

abstract：:The environmental contaminant 6-nitrochrysene (6-NC) has been shown to induce adenomas and adenocarcinomas in the colons of rats. The present study aimed at providing a better understanding of mechanisms that are responsible for this effect. Three female CD rats were injected i.p. with [3,4,9,10-3H]6-NC [9 mumol/rat (...

journal_title：Cancer research

authors： Chae YH,Delclos KB,Blaydes B,el-Bayoumy K

更新日期：1996-05-01 00:00:00

abstract：:Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unb...

journal_title：Cancer research

authors： Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

更新日期：2016-06-01 00:00:00

abstract：:The tumorigenic activity of a series of N-methyl-N'-aryl-N-nitrosoureas (I-X) on mouse skin was investigated in comparison with that of N-methyl-N-nitrosourea (MNU). The tumorigenic potency of I-X was less than that of MNU, although the former are much stronger mutagens; and no correlations were found between the tumo...

journal_title：Cancer research

authors： Yano K,Katayama H,Takemoto K

更新日期：1984-03-01 00:00:00

abstract：:This study investigated the ultrastructure and development of virus particles detected in a spontaneous mammary tumor of an 8 year old rhesus monkey. During a 3-month period of tumor growth, several biopsies were performed. Thin section electron microscopy of the tumor tissue revealed 2 types of particles: 1) an in...

journal_title：Cancer research

authors： Chopra HC,Mason MM

更新日期：1970-08-01 00:00:00

abstract：:Immune effector cells integrate signals that define the nature and magnitude of the subsequent response. Experimental measures for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of permeability or apoptotic changes within a population of targets. Here, we examined individual...

journal_title：Cancer research

authors： Buchser WJ,Laskow TC,Pavlik PJ,Lin HM,Lotze MT

更新日期：2012-06-15 00:00:00