Antibody-mediated redirected cytolysis against murine melanoma cells in vivo.

abstract：:Ovarian cancer is currently the most lethal gynecological malignancy in the United States. Although effective therapies exist, the acquisition of multidrug resistance within persisting tumor cells renders curative therapies elusive for the majority of women with ovarian cancer. In an attempt to better define the evolu...

journal_title：Cancer research

authors： Lamendola DE,Duan Z,Yusuf RZ,Seiden MV

更新日期：2003-05-01 00:00:00

abstract：:Commercially available St. John's wort (Hypericum perforatum) preparations and some of their main constituents (hypericin, pseudohypericin, hyperforin, rutin, and quercetin) were examined for their potential to inhibit carcinogen activation by human cytochrome P450 1A1 (CYP1A1). We used a reconstituted system consisti...

journal_title：Cancer research

authors： Schwarz D,Kisselev P,Roots I

更新日期：2003-11-15 00:00:00

abstract：:The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and ...

journal_title：Cancer research

authors： Gerfaux J,Rousset S,Chany-Fournier F,Chany C

更新日期：1981-09-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). Nevertheless, most individuals infected with HTLV-1 do not develop ATL. To attempt to identify genetic factors promoting the progression to ATL, we investigated in HTLV-1 carriers the relationship between ...

journal_title：Cancer research

authors： Tsukasaki K,Miller CW,Kubota T,Takeuchi S,Fujimoto T,Ikeda S,Tomonaga M,Koeffler HP

更新日期：2001-05-01 00:00:00

abstract：:Monoclonal antibody B72.3, reactive with a high-molecular-weight glycoprotein tumor-associated antigen (designated TAG-72), has been previously shown to be reactive with formalin-fixed paraffin-embedded tissue sections of adenocarcinomas of the ovary, colon, and breast and not a variety of normal adult tissues. It has...

journal_title：Cancer research

authors： Johnston WW,Szpak CA,Thor A,Schlom J

更新日期：1986-12-01 00:00:00

abstract：:Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and resistance to imatinib mesylate treatment remain poorly investigated. Here, we report that CD34(+) progenitors from patients with CML at di...

journal_title：Cancer research

authors： Levescot A,Flamant S,Basbous S,Jacomet F,Féraud O,Anne Bourgeois E,Bonnet ML,Giraud C,Roy L,Barra A,Chomel JC,Turhan A,Guilhot F,Girard JP,Gombert JM,Herbelin A

更新日期：2014-05-15 00:00:00

abstract：:Animal models of human prostate cancer are very limited in number but are of obvious importance to develop. Dr. Morris Pollard (M. Pollard, J. Natl. Cancer Inst., 51: 1235-1241, 1973) has reported that Lobund-Wistar rats develop spontaneous metastatic prostatic cancer when they become old (approximately 25% incidence ...

journal_title：Cancer research

authors： Pugh TD,Chang C,Uemura H,Weindruch R

更新日期：1994-11-15 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitigated and uncertain. Here, we report that PACE4 pre-mRNA undergoes DNA...

journal_title：Cancer research

authors： Couture F,Sabbagh R,Kwiatkowska A,Desjardins R,Guay SP,Bouchard L,Day R

更新日期：2017-12-15 00:00:00

abstract：:It has been suggested that P-glycoprotein (P-gp), an ATP-dependent transporter responsible for classical multidrug resistance, is also a volume-regulated chloride channel. We reexamined this hypothesis by use of whole-cell patch clamp recordings of three matched pairs of cell lines, which were either drug-sensitive or...

journal_title：Cancer research

authors： Dong Y,Chen KG,Durán GE,Kouyama K,Chao AC,Sikic BI,Gollapudi SV,Gupta S,Gardner P

更新日期：1994-10-01 00:00:00

abstract：:The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice bearing mammary adenocarcinomas before tumor cell arrival. In the premetastatic lungs, these immature myeloid...

journal_title：Cancer research

authors： Yan HH,Pickup M,Pang Y,Gorska AE,Li Z,Chytil A,Geng Y,Gray JW,Moses HL,Yang L

更新日期：2010-08-01 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00

abstract：:Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma ...

journal_title：Cancer research

authors： Pitteri SJ,Kelly-Spratt KS,Gurley KE,Kennedy J,Buson TB,Chin A,Wang H,Zhang Q,Wong CH,Chodosh LA,Nelson PS,Hanash SM,Kemp CJ

更新日期：2011-08-01 00:00:00

abstract：:Positive therapeutic effects of interferons (IFNs) in combination with other therapies will depend on defining modalities, doses, and timing of treatment in the setting of varied tumor burdens. When 10(4) P388 leukemia cells were inoculated i.p. on day 0 in BALB/c x DBA/2 F1 mice, all mice died within 18 days if left ...

journal_title：Cancer research

authors： Borden EC,Sidky YA,Hatcher JF,Bryan GT

更新日期：1988-05-01 00:00:00

abstract：:KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated...

journal_title：Cancer research

authors： Ferreyra Solari NE,Belforte FS,Canedo L,Videla-Richardson GA,Espinosa JM,Rossi M,Serna E,Riudavets MA,Martinetto H,Sevlever G,Perez-Castro C

更新日期：2016-09-15 00:00:00

abstract：:The specific delivery of radioisotopes to a tumor at minimal radiation of normal tissue is the ultimate aim of radioimmunotherapy. In this respect a two-step pretargeting regimen generally leads to an improved tumor to normal tissue uptake ratio compared to direct administration of radioimmunoconjugates. In this paper...

journal_title：Cancer research

authors： Bos ES,Kuijpers WH,Meesters-Winters M,Pham DT,de Haan AS,van Doornmalen AM,Kaspersen FM,van Boeckel CA,Gougeon-Bertrand F

更新日期：1994-07-01 00:00:00

abstract：:The purpose of this study was to characterize the transport properties of trimetrexate in WI-L2 human lymphoblastoid cells and determine the mode of resistance that had developed in a subline, WI-L2/TMQ, that was grown in increasing concentrations of trimetrexate. WI-L2/TMQ cells were 62-fold resistant to trimetrexate...

journal_title：Cancer research

authors： Fry DW,Besserer JA

更新日期：1988-12-15 00:00:00

abstract：:Plasma membrane preparations from Chinese hamster lung cells, which are resistant to the antitumor agent Adriamycin, were analyzed using fluorescence polarization of the membrane lipid probe trans-parinaric acid. The results of these studies reveal that membranes from several drug-resistant isolates have a substantial...

journal_title：Cancer research

authors： Rintoul DA,Center MS

更新日期：1984-11-01 00:00:00

abstract：:Glutathione S-transferases have been purified to homogeneity from Chinese hamster liver. Three enzyme forms were separated and designated Forms I, II, and III in order of their elution from carboxymethylcellulose columns. The forms exhibit close physical similarities to glutathione S-transferases B (ligandin) of rat l...

journal_title：Cancer research

authors： Smith GJ,Ohl VS,Litwack G

更新日期：1980-06-01 00:00:00

abstract：:Local irradiation of tumors of rats bearing 3924A hepatomas resulted in more than a doubling of the putrescine levvel and nearly a doubling of spermidine concentration in the serum within 12 hr. Within 24 hr, the putrescine concentration had increased four-fold in the serum, along with a continued increase in the sper...

journal_title：Cancer research

authors： Russell DH,Looney WB,Kovacs CJ,Hopkins HA,Dattilo JW,Morris HP

更新日期：1976-02-01 00:00:00

abstract：:Fifty-nine colonic adenomas and 6 hyperplastic colonic polyps were analyzed by single-strand conformation polymorphism analysis for mutations in the adenomatous polyposis coli gene (APC). Frameshifts and premature stop codons in at least one copy of APC were detected in 25 of these adenomas. Five adenomas carried 2 AP...

journal_title：Cancer research

authors： De Benedetti L,Sciallero S,Gismondi V,James R,Bafico A,Biticchi R,Masetti E,Bonelli L,Heouaine A,Picasso M

更新日期：1994-07-01 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To improve molecular stratification of patients with breast cancer, we developed the Gaussian mixture model (GMM)-based classifier. This probabilistic classifier was ...

journal_title：Cancer research

authors： Prabakaran I,Wu Z,Lee C,Tong B,Steeman S,Koo G,Zhang PJ,Guvakova MA

更新日期：2019-07-01 00:00:00

abstract：:The accumulated literature suggests that altering the immune capacities of animals or humans seldom has detectable effects on tumor incidence nor, it seems, does the growth of an untransplanted tumor, either spontaneous or induced, immunize the host against the growth of a subsequent implant of that tumor. These obser...

journal_title：Cancer research

authors： Prehn RT

更新日期：1994-02-15 00:00:00

abstract：:PAX5 is a transcription factor essential for B-cell development. Recently, it has been found as a frequent target of aberrancies in childhood acute lymphoblastic leukemia (ALL; 30% of B cell ALL cases), showing monoallelic loss, point mutations, or chromosomal translocations. The role of these aberrancies is still poo...

journal_title：Cancer research

authors： Fazio G,Palmi C,Rolink A,Biondi A,Cazzaniga G

更新日期：2008-01-01 00:00:00

abstract：:Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions, and their significance and mode of action have been a source of continuing debate. One proposed mechanism of action of the SNPs is that they would affect the acti...

journal_title：Cancer research

authors： Sur I,Tuupanen S,Whitington T,Aaltonen LA,Taipale J

更新日期：2013-07-15 00:00:00

abstract：:High amounts of nitric oxide (NO) produced by activated macrophages or NO donors are required to induce cytotoxicity and apoptosis in pathogens and tumor cells. High concentrations of NO may lead to nonspecific toxicity thereby limiting the use of NO donors in the treatment of cancer. In this study, we tested the poss...

journal_title：Cancer research

authors： Pervin S,Singh R,Gau CL,Edamatsu H,Tamanoi F,Chaudhuri G

更新日期：2001-06-15 00:00:00

abstract：:Retroviral-mediated delivery of the P140K mutant O(6)-methylguanine-DNA methyltransferase (MGMT(P140K)) into hematopoietic stem cells (HSC) has been proposed as a means to protect against dose-limiting myelosuppressive toxicity ensuing from chemotherapy combining O(6)-alkylating agents (e.g., temozolomide) with pseudo...

journal_title：Cancer research

authors： Milsom MD,Jerabek-Willemsen M,Harris CE,Schambach A,Broun E,Bailey J,Jansen M,Schleimer D,Nattamai K,Wilhelm J,Watson A,Geiger H,Margison GP,Moritz T,Baum C,Thomale J,Williams DA

更新日期：2008-08-01 00:00:00

abstract：:HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a...

journal_title：Cancer research

authors： Borg A,Tandon AK,Sigurdsson H,Clark GM,Fernö M,Fuqua SA,Killander D,McGuire WL

更新日期：1990-07-15 00:00:00

abstract：:Development of resistance to tamoxifen is a serious problem in treatment of breast cancer patients. Although the mechanisms for development of resistance are unclear, an altered expression of alternatively spliced estrogen receptor (ER) mRNA has been suggested to be involved. We have looked for differential expression...

journal_title：Cancer research

authors： Madsen MW,Reiter BE,Larsen SS,Briand P,Lykkesfeldt AE

更新日期：1997-02-15 00:00:00