Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

abstract：:Electron spin resonance (ESR) studies at -130 degrees have been made on frozen samples of normal human cervix and uterus and on frozen samples of various pathological conditions of the cervix and uterus including fibroleiomyoma and carcinoma. Fifty-five samples of normal cervix and endometrium, 40 samples of nonmalign...

journal_title：Cancer research

authors： Benedetto C,Bocci A,Dianzani MU,Ghiringhello B,Slater TF,Tomasi A,Vannini V

更新日期：1981-07-01 00:00:00

abstract：:A phase I clinical trial with granulocyte-macrophage colony-stimulating factor tumor cell vaccines in patients with metastatic renal cell carcinoma (RCC) showed immune cell infiltration at vaccine sites and delayed-type hypersensitivity (DTH) responses to autologous tumor cells indicative of T-cell immunity. To furthe...

journal_title：Cancer research

authors： Zhou X,Jun DY,Thomas AM,Huang X,Huang LQ,Mautner J,Mo W,Robbins PF,Pardoll DM,Jaffee EM

更新日期：2005-02-01 00:00:00

abstract：:The purpose of this paper is to report the extant observations at the Ellis Fischel State Cancer Hospital-Cancer Research Center and in the literature on the gross rates of growth of human mammary cancer as measured for primary cancers in the breast by mammography and for metastatic cancer in the skin and lymph nodes ...

journal_title：Cancer research

authors： Spratt JS Jr,Kaltenbach ML,Spratt JA

更新日期：1977-01-01 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal phenotype with increased migratory and invasive properties. This process has been well described...

journal_title：Cancer research

authors： Sannino G,Marchetto A,Kirchner T,Grünewald TGP

更新日期：2017-09-01 00:00:00

abstract：:The hyperthermic sensitivity of cultured human glioblastoma cells was determined in 1 degree increments from 42 through 46 degrees over the pH range of 6.1 to 7.4. These cells were 5 to 10 times less heat sensitive than were Chinese hamster ovary cells and are among the most resistant cells examined in cell culture. A...

journal_title：Cancer research

authors： Gerweck LE,Richards B

更新日期：1981-03-01 00:00:00

abstract：:We previously reported (J. Galivan et al., Proc. Natl. Acad. Sci. USA, 82: 2598-2602, 1985) the synthesis and characterization of DL-erythro,threo-gamma-fluoromethotrexate (FMTX). The individual diastereomers, DL-erythro-FMTX (eFMTX) and DL-threo-FMTX (tFMTX), and their radiolabeled counterparts have now been prepared...

journal_title：Cancer research

authors： McGuire JJ,Graber M,Licato N,Vincenz C,Coward JK,Nimec Z,Galivan J

更新日期：1989-08-15 00:00:00

abstract：:A role for the immune system in controlling the progression of solid tumors has been established in several mouse models. However, the effect of immune responses and tumor escape on patient prognosis in the context of human cancer is poorly understood. Here, we investigate the cellular and molecular parameters that co...

journal_title：Cancer research

authors： Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J

更新日期：2009-03-15 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful oncoprotein. Dramatic changes in the subcellular localization and function of EphA2 have also been linked with cancer, and in particular, unstable cancer cell-cell contacts prevent EphA2 from s...

journal_title：Cancer research

authors： Coffman KT,Hu M,Carles-Kinch K,Tice D,Donacki N,Munyon K,Kifle G,Woods R,Langermann S,Kiener PA,Kinch MS

更新日期：2003-11-15 00:00:00

abstract：:We have shown that a mutant derivative of Chinese hamster ovary CHO-K1 cells, ADR-5, which shows hypersensitivity to topoisomerase II (topo II)-inhibitory drugs, is cross-sensitive to the site-selective cyclic AMP analogue 8-chloro-cyclic AMP. We tested the hypothesis that overexpression of the type I alpha regulatory...

journal_title：Cancer research

authors： North PS,Davies SL,Ciardiello F,Damiano V,Bianco C,Pepe S,Bianco AR,Harris AL,Hickson ID,Tortora G

更新日期：1994-08-01 00:00:00

abstract：:Genetic differences in metabolism of benzo(a)pyrene (BP) were investigated using cultured epidermal keratinocytes and dermal fibroblasts isolated from four inbred strains of mice: C3H/HeJms and C57BL/6J that are responsive; and DBA/2 and AKR/Jms that are nonresponsive in terms of inducibility of aryl hydrocarbon hydro...

journal_title：Cancer research

authors： Hosomi J,Nemoto N,Kuroki T

更新日期：1983-08-01 00:00:00

abstract：:Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tu...

journal_title：Cancer research

authors： Zhang S,Chitu V,Stanley ER,Elliott BE,Greer PA

更新日期：2011-02-15 00:00:00

abstract：:Malignant pleural mesothelioma is a relatively uncommon and yet incurable tumor. The pathogenesis of mesothelioma remains poorly understood. This study evaluated the role of Wnt signaling in mesothelioma. Western blot analysis was conducted to confirm the expression of Dishevelled (Dvl) and cytosolic beta-catenin in m...

journal_title：Cancer research

authors： Uematsu K,Kanazawa S,You L,He B,Xu Z,Li K,Peterlin BM,McCormick F,Jablons DM

更新日期：2003-08-01 00:00:00

abstract：:(+-)-2-[Hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2- yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide, inner salt (SRI 62-834) is a tetrahydrofuran analogue of platelet activating factor (PAF) that is currently entering clinical trial. Like other ether lipids it is of interest as a membrane-active ...

journal_title：Cancer research

authors： Dive C,Watson JV,Workman P

更新日期：1991-02-01 00:00:00

abstract：:The effects of sodium butyrate, dimethyl sulfoxide (DMSO), and retinoic acid on the growth, morphology, carcinoembryonic antigen content, cell surface membrane-associated enzyme activities, and glycoprotein profiles of a human rectal adenocarcinoma cell line (HRT-18) in culture were compared. All three agents reversib...

journal_title：Cancer research

authors： Tsao D,Morita A,Bella A Jr,Luu P,Kim YS

更新日期：1982-03-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenv...

journal_title：Cancer research

authors： Zhong L,Roybal J,Chaerkady R,Zhang W,Choi K,Alvarez CA,Tran H,Creighton CJ,Yan S,Strieter RM,Pandey A,Kurie JM

更新日期：2008-09-01 00:00:00

abstract：:A megakaryoblastic cell line, termed T-33, was established from the peripheral blood of a patient with Philadelphia chromosome-positive chronic myelogenous leukemia in megakaryoblastic crisis. T-33 cells have been maintained in RPMI 1640 medium containing 10% fetal calf serum in a single cell suspension with a doublin...

journal_title：Cancer research

authors： Tange T,Nakahara K,Mitani K,Yamasaki I,Yasuda H,Tanaka F,Mizuguchi M,Oda H,Yatomi Y,Takanashi R

更新日期：1988-11-01 00:00:00

abstract：:Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has ...

journal_title：Cancer research

authors： Briegert M,Kaina B

更新日期：2007-01-01 00:00:00

abstract：:Insulin-like growth factor I action has been implicated in the pathogenesis of many different malignancies, including breast cancer. Insulin-like growth factor I receptors (IGF-IRs) are overexpressed in virtually all breast cancer cell lines, in which they are believed to enhance growth and inhibit apoptosis. In this ...

journal_title：Cancer research

authors： Resnik JL,Reichart DB,Huey K,Webster NJ,Seely BL

更新日期：1998-03-15 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayer...

journal_title：Cancer research

authors： Auerbach R,Lu WC,Pardon E,Gumkowski F,Kaminska G,Kaminski M

更新日期：1987-03-15 00:00:00

abstract：:Fractalkine is a CX3C-type chemokine that induces chemotaxis of monocytes and cytotoxic T cells. Using the differential display method for examining gene expression in p53-defective cells transfected by adenovirus containing wild-type p53, we observed that fractalkine was induced by ectopic expression of p53. An elect...

journal_title：Cancer research

authors： Shiraishi K,Fukuda S,Mori T,Matsuda K,Yamaguchi T,Tanikawa C,Ogawa M,Nakamura Y,Arakawa H

更新日期：2000-07-15 00:00:00

abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

journal_title：Cancer research

authors： Thomas DB,Karagas MR

更新日期：1987-11-01 00:00:00

abstract：:The possible influence of phenobarbital and phenytoin treatment on cancer risk was investigated in a case-control study nested in a cohort of 8004 epileptic patients in Denmark. Information on anticonvulsive treatments was abstracted for 95% of 60 patients with cancers of the liver and biliary tract or malignant lymph...

journal_title：Cancer research

authors： Olsen JH,Schulgen G,Boice JD Jr,Whysner J,Travis LB,Williams GM,Johnson FB,McGee JO

更新日期：1995-01-15 00:00:00

abstract：:Benzo(e)pyrene [B(e)P] cotreatment slightly increases the tumor-initiating activity of benzo(a)pyrene [B(a)P] and greatly decreases the tumor-initiating activity of 7,12-dimethylbenz(a)anthracene (DMBA) in Sencar mice (DiGiovanni et al., Carcinogenesis 3: 371-375, 1982). The effects of B(e)P on the binding of B(a)P an...

journal_title：Cancer research

authors： Smolarek TA,Baird WM,Fisher EP,DiGiovanni J

更新日期：1987-07-15 00:00:00

abstract：:Inhibitors of 5alpha-reductase (SRD5A) that lower intraprostatic levels of dihydrotestosterone (DHT) reduce the overall incidence of prostate cancer (PCa), but there is significant variation in chemopreventive activity between individual men. In seeking molecular alterations that might underlie this variation, we comp...

journal_title：Cancer research

authors： Mostaghel EA,Geng L,Holcomb I,Coleman IM,Lucas J,True LD,Nelson PS

更新日期：2010-02-15 00:00:00

abstract：:beta 1-4 N-acetylglucosaminyltransferase (GnT-III) catalyzes the formation of bisecting N-acetylglucosamine (GlcNAc) in the biosynthesis of N-linked oligosaccharides. To examine the effect of bisecting GlcNAc on the natural killer (NK) cytotoxicity, the GnT-111 gene was introduced into NK-sensitive K562 cells that hav...

journal_title：Cancer research

authors： Yoshimura M,Ihara Y,Ohnishi A,Ijuhin N,Nishiura T,Kanakura Y,Matsuzawa Y,Taniguchi N

更新日期：1996-01-15 00:00:00

abstract：:In order to determine the potential role of sex steroid and 1,25-dihydroxyvitamin D3 in the spreading of colorectal cancer, previously hypothesized from epidemiological and experimental data, specific androgen (AR, n = 94), estrogen (ER, n = 60), progesterone (PGR, n = 50), and 1,25-dihydroxyvitamin D3 receptors (VDR,...

journal_title：Cancer research

authors： Meggouh F,Lointier P,Saez S

更新日期：1991-02-15 00:00:00

abstract：:Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which they mediate their effects are not yet fully understood. In this study, we show that FOH is an effective inducer of apoptosis in several lung ca...

journal_title：Cancer research

authors： Joo JH,Liao G,Collins JB,Grissom SF,Jetten AM

更新日期：2007-08-15 00:00:00

abstract：:Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of the proteasome. We hypothesized that proteasome inhibition would lead to an accumulation of misfolded proteins in the cell resulting in endoplasmic reticulum (ER) stress. The ability of bor...

journal_title：Cancer research

authors： Nawrocki ST,Carew JS,Dunner K Jr,Boise LH,Chiao PJ,Huang P,Abbruzzese JL,McConkey DJ

更新日期：2005-12-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to the clinical imaging abnormality. Hypoxia, a hallmark of aggressive tumor behavior often noted in GBMs, has been associated with resistance to t...

journal_title：Cancer research

authors： Szeto MD,Chakraborty G,Hadley J,Rockne R,Muzi M,Alvord EC Jr,Krohn KA,Spence AM,Swanson KR

更新日期：2009-05-15 00:00:00