Involvement of plasma membrane lipid structural order in adriamycin resistance in Chinese hamster lung cells.

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:Communication between cancer cells and the tumor microenvironment results in the modulation of complex signaling networks that facilitate tumor progression. Here, we describe a new mechanism of intercellular communication originating from large oncosomes (LO), which are cancer cell-derived, atypically large (1-10 μm) ...

journal_title：Cancer research

authors： Minciacchi VR,Spinelli C,Reis-Sobreiro M,Cavallini L,You S,Zandian M,Li X,Mishra R,Chiarugi P,Adam RM,Posadas EM,Viglietto G,Freeman MR,Cocucci E,Bhowmick NA,Di Vizio D

更新日期：2017-05-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-I has well-characterized mitogenic and antiapoptotic effects that are essential for maintenance of the normal prostate and may be important during regression of the normal prostate and/or prostate tumors induced by androgen-targeting therapies for prostate cancer. IGF-I activity is mod...

journal_title：Cancer research

authors： Nickerson T,Miyake H,Gleave ME,Pollak M

更新日期：1999-07-15 00:00:00

abstract：:The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against established immunogenic (MCA-106) and nonimmunogenic (MCA-102) sarcomas at both s.c. and visceral (hepatic) sites. C57BL/6 (B6) mice were treated with a single i...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Merino MJ,Rosenberg SA

更新日期：1988-07-15 00:00:00

abstract：:L-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-beta]thiazole hydrochloride (LMS), when used in concert with 1,3-bis(2-chloroethyl)-1-nitrosourea, resulted in a significantly higher percentage of long-term leukemic-free survivors. The additive effect provided by LMS treatment was evident during the immunosuppressed period in...

journal_title：Cancer research

authors： Chirigos MA,Fuhrman F,Pryor J

更新日期：1975-04-01 00:00:00

abstract：:We studied loss of heterozygosity (LOH) on human chromosome 7q to determine the location of a putative tumor suppressor gene (TSG) in human primary prostate carcinomas. Samples were obtained from 16 primary prostate carcinomas surgically removed from patients at The University of Texas M. D. Anderson Cancer Center. Pa...

journal_title：Cancer research

authors： Zenklusen JC,Thompson JC,Troncoso P,Kagan J,Conti CJ

更新日期：1994-12-15 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:Milk from a number of species (e.g., man, mouse, rat, dog, and cow) contains inhibitors of the RNA-directed DNA polymerase. When attempts are made to isolate virions from the milk, part of the inhibitors follow the virions in the purification. The amount of inhibitors varies in different milk samples. These inhibitors...

journal_title：Cancer research

authors： Sanner T

更新日期：1976-02-01 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:This study investigated the effect of recombinant human tumor necrosis factor (rhTNF) on hydroxyl radical production by established cell lines in vitro, and its implication in the killing of tumor cells by rhTNF. During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells (2 X 10(7) cells) in the presenc...

journal_title：Cancer research

authors： Yamauchi N,Kuriyama H,Watanabe N,Neda H,Maeda M,Niitsu Y

更新日期：1989-04-01 00:00:00

abstract：:The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene expression and genome instability. A genome-wide analysis to evaluate ...

journal_title：Cancer research

authors： Xiang Y,Yan K,Zheng Q,Ke H,Cheng J,Xiong W,Shi X,Wei L,Zhao M,Yang F,Wang P,Lu X,Fu L,Lu X,Li F

更新日期：2019-01-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:BCL2 suppresses apoptosis by binding the BH3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. Many tumor types, including B-cell lymphomas and chronic lymphocytic leukemia, are dependent on BCL2 for survival but become resistant to apoptosis after treatment. Here, we...

journal_title：Cancer research

authors： Dutta C,Day T,Kopp N,van Bodegom D,Davids MS,Ryan J,Bird L,Kommajosyula N,Weigert O,Yoda A,Fung H,Brown JR,Shapiro GI,Letai A,Weinstock DM

更新日期：2012-08-15 00:00:00

abstract：:The efficacy of novel cancer therapeutics has been hampered by the ability to deliver these agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been shown to increase drug delivery to tumors. Particle size ha...

journal_title：Cancer research

authors： Kong G,Braun RD,Dewhirst MW

更新日期：2000-08-15 00:00:00

abstract：:The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bear...

journal_title：Cancer research

authors： Barbazán J,Alonso-Alconada L,Elkhatib N,Geraldo S,Gurchenkov V,Glentis A,van Niel G,Palmulli R,Fernández B,Viaño P,Garcia-Caballero T,López-López R,Abal M,Vignjevic DM

更新日期：2017-07-01 00:00:00

abstract：:Calorie restriction has been shown to inhibit epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, including insulin-like growth factor I (IGF-I). Previously, we identified a relationship between elevated tissue IGF-I levels and enhanced susceptibility to chemically induc...

journal_title：Cancer research

authors： Moore T,Carbajal S,Beltran L,Perkins SN,Yakar S,Leroith D,Hursting SD,Digiovanni J

更新日期：2008-05-15 00:00:00

abstract：:Bile acids increase the proliferative activity of rat colonic epithelium. However, the mechanisms responsible are unknown. The present study examined the relationships between deoxycholate (DOC) induced surface cell sloughing, as measured by loss of DNA into the lumen and by light microscopy, and the subsequent increa...

journal_title：Cancer research

authors： Craven PA,Pfanstiel J,Saito R,DeRubertis FR

更新日期：1986-11-01 00:00:00

abstract：:Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need to develop effective treatments using newly available preclinical models for therapeutic discovery and drug evaluation. Here we use multiomics integration of wh...

journal_title：Cancer research

authors： Shrestha R,Llaurado Fernandez M,Dawson A,Hoenisch J,Volik S,Lin YY,Anderson S,Kim H,Haegert AM,Colborne S,Wong NKY,McConeghy B,Bell RH,Brahmbhatt S,Lee CH,DiMattia GE,Le Bihan S,Morin GB,Collins CC,Carey MS

更新日期：2021-01-13 00:00:00

abstract：:A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issu...

journal_title：Cancer research

authors： Nikolsky Y,Sviridov E,Yao J,Dosymbekov D,Ustyansky V,Kaznacheev V,Dezso Z,Mulvey L,Macconaill LE,Winckler W,Serebryiskaya T,Nikolskaya T,Polyak K

更新日期：2008-11-15 00:00:00

abstract：:A method for the preparation of biologically active [3H]- and [13C]bleomycin A2 is described. Demethyl Cu(II):bleomycin A2, isolated after pyrolysis of Cu(II):bleomycin A2, was methylated with either [3H]-or [13C]methyl iodide, which resulted in Cu(II):bleomycin A2 labeled in the dimethylsulfonium moiety. Copper was r...

journal_title：Cancer research

authors： Roy SN,Orr GA,Brewer CF,Horwitz SB

更新日期：1981-11-01 00:00:00

abstract：:The ets oncogene superfamily codes for a family of transcriptional factors that are involved in gene regulation not only by autonomous DNA binding but also by indirect DNA binding through interaction with cellular factors. We have previously shown that a member of this superfamily, elk-1, is a sequence specific transc...

journal_title：Cancer research

authors： Rao VN,Reddy ES

更新日期：1993-01-15 00:00:00

abstract：:Neuroblastomas are histopathologically heterogeneous, ranging from immature malignant tumors to benign ganglioneuromas. The amount of Schwann cell stroma greatly increases with neuroblastoma differentiation, and these Schwann cells appear to be normal cells that infiltrate the tumor. To determine whether Schwann cells...

journal_title：Cancer research

authors： Kwiatkowski JL,Rutkowski JL,Yamashiro DJ,Tennekoon GI,Brodeur GM

更新日期：1998-10-15 00:00:00

abstract：:A transplantable mammary tumor derived from an outgrowth of nodule-like alveolar lesions induced by 7,12-dimethylbenz[a]anthracene in cultures of whole mammary gland was shown to produce a family of somatomedin-like polypeptides when cultured in vitro. Minced mammary tumor tissue as well as monolayer cultures of tumor...

journal_title：Cancer research

authors： Knauer DJ,Iyer AP,Banerjee MR,Smith GL

更新日期：1980-12-01 00:00:00

abstract：:Integral membrane proteins are visualized as intramembrane particles (IMP; also called membrane-associated particles) at the cleaved surfaces of freeze-fractured plasma membranes. Topographical distributions of the IMP of urothelial cell membranes in normal human bladder and for a small series of low-grade noninvasive...

journal_title：Cancer research

authors： Weinstein RS

更新日期：1976-07-01 00:00:00

abstract：:Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still...

journal_title：Cancer research

authors： Fujita-Sato S,Galeas J,Truitt M,Pitt C,Urisman A,Bandyopadhyay S,Ruggero D,McCormick F

更新日期：2015-07-15 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00

abstract：:Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well as breast cancer patients and survivors use black cohosh to relieve vasomotor symptoms, there is ...

journal_title：Cancer research

authors： Davis VL,Jayo MJ,Ho A,Kotlarczyk MP,Hardy ML,Foster WG,Hughes CL

更新日期：2008-10-15 00:00:00

abstract：:Cancer vaccines may have applications in the therapy and prevention of mammary carcinoma. To investigate such applications, we constructed a recombinant adenoviral vaccine expressing a kinase-inactive mutant form of human HER2 and introduced this into BALB/c wild-type (WT) or HER2 transgenic mice. Here, we report cont...

journal_title：Cancer research

authors： Triulzi C,Vertuani S,Curcio C,Antognoli A,Seibt J,Akusjärvi G,Wei WZ,Cavallo F,Kiessling R

更新日期：2010-10-01 00:00:00

abstract：:Cardiotoxicity limits the use of anthracyclines which are potent anticancer agents. In the isolated rat heart, we investigated the mechanism of acute anthracycline cardiotoxicity and compared a new anthracycline, carminomycin, with daunomycin which is in established use. Daunomycin 1.75 X 10(-5) M produced a fall in c...

journal_title：Cancer research

authors： Saman S,Jacobs P,Opie LH

更新日期：1984-04-01 00:00:00

abstract：:The possible mutagenic potential of exposure to 1.5 GHz electromagnetic near field (EMF) was investigated using brain tissues of Big Blue mice (BBM). Male BBM were locally exposed to EMF in the head region at 2.0, 0.67, and 0 W/kg specific absorption rate for 90 min/day, 5 days/week, for 4 weeks. No gliosis or degener...

journal_title：Cancer research

authors： Takahashi S,Inaguma S,Cho YM,Imaida K,Wang J,Fujiwara O,Shirai T

更新日期：2002-04-01 00:00:00