Abstract：
:The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bearing primary tumors and are also present in vessels from human livers affected with metastases. Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions. Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation in vivo Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells. Cancer Res; 77(13); 3431-41. ©2017 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Barbazán J,Alonso-Alconada L,Elkhatib N,Geraldo S,Gurchenkov V,Glentis A,van Niel G,Palmulli R,Fernández B,Viaño P,Garcia-Caballero T,López-López R,Abal M,Vignjevic DMdoi
10.1158/0008-5472.CAN-16-1917subject
Has Abstractpub_date
2017-07-01 00:00:00pages
3431-3441issue
13eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-16-1917journal_volume
77pub_type
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