Overexpression of CDC25A and CDC25B in head and neck cancers.

abstract：:Retinoids that regulate cell growth, differentiation, and apoptosis have shown promising results in preclinical studies and in a few clinical trials of cancer chemoprevention and therapy. However, the clinical use of retinoids is limited by resistance of certain malignant cells to their antitumor effects and by side e...

journal_title：Cancer research

authors： Chun KH,Benbrook DM,Berlin KD,Hong WK,Lotan R

更新日期：2003-07-01 00:00:00

abstract：:An indirect immunofluorescence assay was used to detect estradiol in MCF-7 breast cancer cells to determine if the estradiol-specific fluorescence observed represented estrogen receptor-bound estradiol. Appropriate controls were used to demonstrate the immunological specificity of our assay procedures. Initial studies...

journal_title：Cancer research

authors： Mercer WD,Edwards DP,Chamness GC,McGuire WL

更新日期：1981-11-01 00:00:00

abstract：:In this study the cytokinetic and antitumor effects of 12-h continuous treatment with 6-thioguanine (TG) were studied in L1210 cells in vivo and in vitro. Loss of clonogenicity in vitro was maximized at a drug concentration of 0.2 microM. Higher drug concentrations produced less cell kill, and the surviving fraction o...

journal_title：Cancer research

authors： Maybaum J,Morgans CW,Hink LA

更新日期：1987-06-15 00:00:00

abstract：:We conducted a case-control study of estrogen receptor (ER) and progesterone receptor (PgR) expression in benign breast epithelium from 120 women (51 breast cancer cases and 69 benign disease controls) who underwent breast operations at University Hospital, Syracuse, New York. Benign samples were obtained and processe...

journal_title：Cancer research

authors： Khan SA,Rogers MA,Obando JA,Tamsen A

更新日期：1994-02-15 00:00:00

abstract：:The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasion of cancer cells, such as matrix metalloproteinases (MMP), have potential E2F-binding sites in the...

journal_title：Cancer research

authors： Johnson JL,Pillai S,Pernazza D,Sebti SM,Lawrence NJ,Chellappan SP

更新日期：2012-01-15 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:The effect of the potent angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470), a semisynthetic analogue of fumagillin, on tumor growth and metastasis was studied using rodent tumors. Injection of TNP-470 s.c. inhibited tumor growth in a dose-dependent manner, and the tumor sizes of B16BL6 melanoma, M5...

journal_title：Cancer research

authors： Yamaoka M,Yamamoto T,Masaki T,Ikeyama S,Sudo K,Fujita T

更新日期：1993-09-15 00:00:00

abstract：:The critical region on human chromosome 3p21.3 harboring a putative lung cancer tumor suppressor gene (TSG) was previously defined by allelotyping and recently refined by overlapping homozygous deletions. We report the construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and it...

journal_title：Cancer research

authors： Wei MH,Latif F,Bader S,Kashuba V,Chen JY,Duh FM,Sekido Y,Lee CC,Geil L,Kuzmin I,Zabarovsky E,Klein G,Zbar B,Minna JD,Lerman MI

更新日期：1996-04-01 00:00:00

abstract：:Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense investigation. Here we report the biological properties of GDC-0879, a hig...

journal_title：Cancer research

authors： Hoeflich KP,Herter S,Tien J,Wong L,Berry L,Chan J,O'Brien C,Modrusan Z,Seshagiri S,Lackner M,Stern H,Choo E,Murray L,Friedman LS,Belvin M

更新日期：2009-04-01 00:00:00

abstract：:The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

journal_title：Cancer research

authors： Howard RA,Spring TG,Bear JL

更新日期：1976-12-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, i...

journal_title：Cancer research

authors： Wu W,Kemp BL,Proctor ML,Gazdar AF,Minna JD,Hong WK,Mao L

更新日期：1999-04-15 00:00:00

abstract：:Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods to distinguish between functional and benign variants. Here we used fu...

journal_title：Cancer research

authors： Hanrahan AJ,Sylvester BE,Chang MT,Elzein A,Gao J,Han W,Liu Y,Xu D,Gao SP,Gorelick AN,Jones AM,Kiliti AJ,Nissan MH,Nimura CA,Poteshman AN,Yao Z,Gao Y,Hu W,Wise HC,Gavrila EI,Shoushtari AN,Tiwari S,Viale A,Abd

更新日期：2020-10-01 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:Using a microcytotoxicity assay we have studied the immune responses to the preneoplastic, hyperplastic alveolar nodule (HAN) lines D1 and D2 and to the mammary tumors arising spontaneously from them in BALB/c mice. Lymph node cells (LNC) from mice bearing HAN implants, or from mice whose implants had been removed gre...

journal_title：Cancer research

authors： Heppner GH,Kopp JS,Medina D

更新日期：1976-02-01 00:00:00

abstract：:The treatment of K562 human myeloblastic leukemia cells and YAC-1 murine lymphoma cells with cadeguomycin at concentrations over 0.6 microM significantly enhanced the cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C). The degree of potentiation depended upon the antibiotic concentration. The treatment with 75 ...

journal_title：Cancer research

authors： Suzuki H,Kim SH,Tanara M,Okazaki K,Okabe T,Wu RT,Tanaka N

更新日期：1987-02-01 00:00:00

abstract：:Removal of T-lymphocytes from marrow inoculum with monoclonal antibody plus complement permitted establishment of long-lived allogeneic chimeras between C57BL/6 and AKR/J mice. Development of leukemia was prevented for 15 mo. Protection from leukemia occurred with both young (4 wk) and older (4 mo) recipients. AKR mic...

journal_title：Cancer research

authors： Wustrow TP,Good RA

更新日期：1985-12-01 00:00:00

abstract：:It has been hypothesized that complement inhibitors expressed on the surface of tumor cells prevent effective immune-mediated clearance. Whereas there are in vitro data to support this hypothesis, the species-selective activity of complement inhibitors has been a hindrance to investigating the role of membrane-bound c...

journal_title：Cancer research

authors： Chen S,Caragine T,Cheung NK,Tomlinson S

更新日期：2000-06-01 00:00:00

abstract：:Estrogen receptor-related receptors (ERR) are orphan nuclear receptors, which are constitutively activated without estrogen binding. Recent evidence indicates that the ligand-independent ERRs may be involved in similar ER-mediated regulatory pathways and modulate estrogen responsiveness in certain target cells. We rec...

journal_title：Cancer research

authors： Yu S,Wang X,Ng CF,Chen S,Chan FL

更新日期：2007-05-15 00:00:00

abstract：:The clinical management of cutaneous melanoma would benefit significantly from a better understanding of the molecular changes that occur during melanocytic progression to a melanoma phenotype. To gain unique insights into this process, we developed a three-dimensional in vitro model that allows observations of normal...

journal_title：Cancer research

authors： Seftor EA,Brown KM,Chin L,Kirschmann DA,Wheaton WW,Protopopov A,Feng B,Balagurunathan Y,Trent JM,Nickoloff BJ,Seftor RE,Hendrix MJ

更新日期：2005-11-15 00:00:00

abstract：:We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

journal_title：Cancer research

authors： Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

更新日期：1986-07-01 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparation...

journal_title：Cancer research

authors： Lee JS,Pathak S,Hopwood V,Tomasovic B,Mullins TD,Baker FL,Spitzer G,Neidhart JA

更新日期：1987-12-01 00:00:00

abstract：:A large number of epidemiological studies have shown that regular use of aspirinor other nonsteroidal anti-inflammatory drugs (NSAIDs) results in a 40-50% reduced risk of colorectal cancer (CRC). Furthermore, NSAIDs cause the regression of preexisting adenomas in patients with familial adenomatous polyposis and signif...

journal_title：Cancer research

authors： Yao M,Kargman S,Lam EC,Kelly CR,Zheng Y,Luk P,Kwong E,Evans JF,Wolfe MM

更新日期：2003-02-01 00:00:00

abstract：:Approximately 10% of gastric adenocarcinomas worldwide are associated with human EBV. These carcinomas generally do not express the latent membrane protein 1 (LMP1), the major known EBV oncogene. Recently, another EBV gene [ie., BARF1 (BamHI A rightward open reading frame)] was shown to have transforming and immortali...

journal_title：Cancer research

authors： zur Hausen A,Brink AA,Craanen ME,Middeldorp JM,Meijer CJ,van den Brule AJ

更新日期：2000-05-15 00:00:00

abstract：:Cellular pools of free arachidonic acid are tightly controlled through enzymatic release of the fatty acid and subsequent utilization by downstream enzymes including the cyclooxygenases. Arachidonic acid cleavage from membrane phospholipids is accomplished by the actions of phospholipase A(2) (PLA(2)). Upon release, f...

journal_title：Cancer research

authors： Ilsley JN,Nakanishi M,Flynn C,Belinsky GS,De Guise S,Adib JN,Dobrowsky RT,Bonventre JV,Rosenberg DW

更新日期：2005-04-01 00:00:00

abstract：:When Shionogi carcinoma 115 (SC115, an undifferentiated medullary carcinoma showing a compact cell pattern and containing androgen receptor) was transplanted into male and female DS mice, it grew only in males. In contrast with this strict androgen dependency in DS hosts, SC115 tumors grew in male and female nude athy...

journal_title：Cancer research

authors： Kitamura Y,Uchida N,Hayata I,Yamaguchi K,Okamoto S,Narita N,Matsumoto K

更新日期：1980-12-01 00:00:00

abstract：:Biologically active phorbol ester derivatives displace [3H]phorbol-12, 13-dibutyrate from thioglycollate-elicited mouse peritoneal macrophages in a time-, temperature-, and concentration-dependent manner. Scatchard analysis revealed an apparent Kd of 54.1 nM and 8.0 X 10(5) sites/cell, indicating that these macrophage...

journal_title：Cancer research

authors： Sturm RJ,Smith BM,Lane RW,Laskin DL,Harris LS,Carchman RA

更新日期：1983-10-01 00:00:00

abstract：:Checkpoint inhibitors like anti-PD1/PD-L1 have demonstrated significant therapeutic efficacy in a subset of patients partly through reinvigoration of CD8 T cells. However, their impact on myeloid cells remains largely unknown. Here, we report that anti-PD-L1 treatment favorably impacts the phenotype and function of tu...

journal_title：Cancer research

authors： Xiong H,Mittman S,Rodriguez R,Moskalenko M,Pacheco-Sanchez P,Yang Y,Nickles D,Cubas R

更新日期：2019-04-01 00:00:00