Abstract：
:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and relapse less than 5 weeks after androgen withdrawal. After androgen withdrawal, the human primary prostate cancer xenograft CWR22 regresses markedly, and prostate-specific antigen (PSA) falls up to 3000-fold in the blood of mice. PSA usually returns to normal. In some animals, the tumor relapses and is then designated CWR22R. In these animals, PSA starts to rise approximately 2-7 months, and tumor begins to grow 3-10 months after castration. Animals with CWR22 need to be euthanized because of large tumors 6-12 weeks after the transplantation of CWR22. Androgen withdrawal prolongs life approximately 3-4-fold.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TGsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
3042-6issue
13eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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