Tumor-microenvironment interactions: the fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells.

abstract：:It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). ...

journal_title：Cancer research

authors： Song P,Sekhon HS,Jia Y,Keller JA,Blusztajn JK,Mark GP,Spindel ER

更新日期：2003-01-01 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML). As the mechanisms leading to RKIP loss in AML...

journal_title：Cancer research

authors： Hatzl S,Geiger O,Kuepper MK,Caraffini V,Seime T,Furlan T,Nussbaumer E,Wieser R,Pichler M,Scheideler M,Nowek K,Jongen-Lavrencic M,Quehenberger F,Wölfler A,Troppmair J,Sill H,Zebisch A

更新日期：2016-06-15 00:00:00

abstract：:After the Chernobyl accident, the incidence of urinary bladder cancers in the Ukraine population increased gradually from 26.2 to 36.1 per 100,000 between 1986 and 1996. Urinary bladder epithelium biopsied from 45 male patients with benign prostatic hyperplasia living in radiocontaminated areas of Ukraine demonstrated...

journal_title：Cancer research

authors： Yamamoto S,Romanenko A,Wei M,Masuda C,Zaparin W,Vinnichenko W,Vozianov A,Lee CC,Morimura K,Wanibuchi H,Tada M,Fukushima S

更新日期：1999-08-01 00:00:00

abstract：:Nerve growth factor-like substance(s) were identified in both conditioned media of a human prostatic tumor epithelial cell line (TSU-pr1) and a human prostatic stromal cell line (HPS) by Western blot analysis and bioassay of neurite outgrowth of PC12 cells. Nerve growth factor-beta (NGF) immunofluorescence was also lo...

journal_title：Cancer research

authors： Djakiew D,Delsite R,Pflug B,Wrathall J,Lynch JH,Onoda M

更新日期：1991-06-15 00:00:00

abstract：:Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine therapy. In these tumors, ERα repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deac...

journal_title：Cancer research

authors： Sabnis GJ,Goloubeva O,Chumsri S,Nguyen N,Sukumar S,Brodie AM

更新日期：2011-03-01 00:00:00

abstract：:Blood tests to detect circulating tumor cells (CTC) offer great potential to monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For patients with brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell s...

journal_title：Cancer research

authors： Macarthur KM,Kao GD,Chandrasekaran S,Alonso-Basanta M,Chapman C,Lustig RA,Wileyto EP,Hahn SM,Dorsey JF

更新日期：2014-04-15 00:00:00

abstract：:Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success la...

journal_title：Cancer research

authors： Siddiqui IA,Adhami VM,Bharali DJ,Hafeez BB,Asim M,Khwaja SI,Ahmad N,Cui H,Mousa SA,Mukhtar H

更新日期：2009-03-01 00:00:00

abstract：:The process of monoclonal antibody (MAb) binding to tumor cells is greatly influenced by the biology of the respective antigen. This was concluded from an analysis of binding and release of MAbs and MAb fragments to melanoma cells at different concentration levels and different temperatures. With an antigen known to b...

journal_title：Cancer research

authors： Matzku S,Bröcker EB,Brüggen J,Dippold WG,Tilgen W

更新日期：1986-08-01 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:Microsatellite instability (MSI) has been described in tumors from patients with hereditary nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI is caused by the dysfunction of mismatch repairs genes. Loss of expression and mutation in one of the major mismatch repair genes, hMLH...

journal_title：Cancer research

authors： Deng G,Chen A,Hong J,Chae HS,Kim YS

更新日期：1999-05-01 00:00:00

abstract：:Antibody-based cancer treatment depends upon distribution of the targeting macromolecule throughout tumor tissue, and spatial heterogeneity could significantly limit efficacy in many cases. Antibody distribution in tumor tissue is a function of drug dosage, antigen concentration, binding affinity, antigen internalizat...

journal_title：Cancer research

authors： Thurber GM,Wittrup KD

更新日期：2008-05-01 00:00:00

abstract：:Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (EGFR)-targeted therapies, limited clinical testing for RAS pathway mutations has recently been adopted. We performed a multiplatform genomic a...

journal_title：Cancer research

authors： Janakiraman M,Vakiani E,Zeng Z,Pratilas CA,Taylor BS,Chitale D,Halilovic E,Wilson M,Huberman K,Ricarte Filho JC,Persaud Y,Levine DA,Fagin JA,Jhanwar SC,Mariadason JM,Lash A,Ladanyi M,Saltz LB,Heguy A,Paty PB,Solit

更新日期：2010-07-15 00:00:00

abstract：:A malignant hamster melanoma cell line HM-1 derived from the heterogenous malignant hamster melanoma MM1 contains a specific, high affinity binding protein for estrogens. Partial purification of the binding protein with ammonium sulfate (40% saturation) increased mean binding content (3.1 +/- 1.2 (SD) fmol/mg protein)...

journal_title：Cancer research

authors： Schleicher RL,Hitselberger MH,Beattie CW

更新日期：1987-01-15 00:00:00

abstract：:Telomerase is essential for immortalization of most human cancer cells. Expression of the core telomerase RNA (hTR) and reverse transcriptase (hTERT) subunits is mainly regulated by transcription. However, hTR transcriptional regulation remains poorly understood. We previously showed that the core hTR promoter is acti...

journal_title：Cancer research

authors： Bilsland AE,Stevenson K,Atkinson S,Kolch W,Keith WN

更新日期：2006-02-01 00:00:00

abstract：:Human polynucleotide phosphorylase (hPNPase(old-35)) is a type I IFN-inducible 3',5' exoribonuclease that mediates mRNA degradation. In melanoma cells, slow and sustained overexpression of hPNPase(old-35) induces G(1) cell cycle arrest ultimately culminating in apoptosis, whereas rapid overexpression of hPNPase(old-35...

journal_title：Cancer research

authors： Sarkar D,Park ES,Barber GN,Fisher PB

更新日期：2007-09-01 00:00:00

abstract：:The responses of male noninbred rat colonic epithelial ornithine decarboxylase (EC 4.1.1.17) (ODC) and S-adenosyl-L-methionine decarboxylase (EC 4.1.1.50) (SAMD) activities following topical administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or bile salts were studied. A single intrarectal installation of 1...

journal_title：Cancer research

authors： Takano S,Matsushima M,Ertürk E,Bryan GT

更新日期：1981-02-01 00:00:00

abstract：:There are now more than 10 million cancer survivors in the United States. With these numbers, chronic sequelae that result from cancer therapy have become a major health care problem. Although radiation therapy of the brain has improved cancer cure rates, learning disorders and memory deficits are a common consequence...

journal_title：Cancer research

authors： Thotala DK,Hallahan DE,Yazlovitskaya EM

更新日期：2008-07-15 00:00:00

abstract：:DNA methylation patterns are established and maintained by three DNA methyltransferases (DNMT): DNMT1, DNMT3A, and DNMT3B. Although essential for development, methylation patterns are frequently disrupted in cancer and contribute directly to carcinogenesis. Recent studies linking polycomb group repression complexes (P...

journal_title：Cancer research

authors： Jin B,Yao B,Li JL,Fields CR,Delmas AL,Liu C,Robertson KD

更新日期：2009-09-15 00:00:00

abstract：:The tumorigenic activity of a series of N-methyl-N'-aryl-N-nitrosoureas (I-X) on mouse skin was investigated in comparison with that of N-methyl-N-nitrosourea (MNU). The tumorigenic potency of I-X was less than that of MNU, although the former are much stronger mutagens; and no correlations were found between the tumo...

journal_title：Cancer research

authors： Yano K,Katayama H,Takemoto K

更新日期：1984-03-01 00:00:00

abstract：:Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mi...

journal_title：Cancer research

authors： Felix K,Kelliher K,Bornkamm GW,Janz S

更新日期：1998-04-15 00:00:00

abstract：:: TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squam...

journal_title：Cancer research

authors： Yanagi T,Watanabe M,Hata H,Kitamura S,Imafuku K,Yanagi H,Homma A,Wang L,Takahashi H,Shimizu H,Hatakeyama S

更新日期：2018-12-15 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:Asian diets high in soy are associated with lower risk for breast cancer compared with Western diets. Moreover, higher levels of two putative carcinogenic metabolites of 17beta-estradiol, 4- and 16alpha-hydroxyestrogen, and lower amounts of anticarcinogenic metabolites, 2-hydroxyestrogens, have been associated with gr...

journal_title：Cancer research

authors： Lu LJ,Cree M,Josyula S,Nagamani M,Grady JJ,Anderson KE

更新日期：2000-03-01 00:00:00

abstract：:50C10 and 52H10 are two DNA clones previously reported by us to be overexpressed in human colonic mucosa at high risk for development of colonic tumors. This report presents sequencing data that reveal that these clones contain repetitive Alu elements. Each Alu sequence is associated with a 3'-oligoadenylate [oligo(A)...

journal_title：Cancer research

authors： Chen J,Heerdt BG,Augenlicht LH

更新日期：1995-01-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is highly expressed by both normal and malignant prostate epithelial cells and by the neovasculature of many tumor types; however, it is not expressed by normal endothelial cells or other normal tissues. PSMA, therefore, represents an attractive candidate for selectively targe...

journal_title：Cancer research

authors： Aggarwal S,Singh P,Topaloglu O,Isaacs JT,Denmeade SR

更新日期：2006-09-15 00:00:00

abstract：:8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H) -one (mitozolomide) demonstrates curative action against a range of murine tumor model systems. At single doses of between 20 and 40 mg/kg, the latter of which approximates the 10% lethal dose value in mice, the compound elicited cures against the L121...

journal_title：Cancer research

authors： Hickman JA,Stevens MF,Gibson NW,Langdon SP,Fizames C,Lavelle F,Atassi G,Lunt E,Tilson RM

更新日期：1985-07-01 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:Diagnosis of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), particularly HCC independent of cirrhosis etiology, presents a great challenge because of a lack of biomarkers. Here we test the hypothesis that expression profiles of microRNAs (miRNAs) in serum can serve as biomarkers for diagnosis of HBV ...

journal_title：Cancer research

authors： Li LM,Hu ZB,Zhou ZX,Chen X,Liu FY,Zhang JF,Shen HB,Zhang CY,Zen K

更新日期：2010-12-01 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00