Abstract：
:Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Felix K,Kelliher K,Bornkamm GW,Janz Ssubject
Has Abstractpub_date
1998-04-15 00:00:00pages
1616-9issue
8eissn
0008-5472issn
1538-7445journal_volume
58pub_type
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