Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.

abstract：:The effect of type (corn oil or lard) and quantity (5 or 20%) of dietary fat and 1,2-dimethylhydrazine (DMH) on the composition of biliary bile acids, fecal bile acids, and neutral sterols was studied in rats exposed to a given regimen for two generations prior to s.c. treatment with DMH for 20 weeks. Biliary excretio...

journal_title：Cancer research

authors： Reddy BS,Mangat S,Sheinfil A,Weisburger JH,Wynder EL

更新日期：1977-07-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) receptor agonists are extensively used in the treatment of sex hormone-dependent cancers via the desensitization of pituitary gonadotropes and consequent decrease in steroid sex hormone secretion. However, evidence now points to a direct inhibitory effect of GnRH analogs on cancer...

journal_title：Cancer research

authors： Maudsley S,Davidson L,Pawson AJ,Chan R,López de Maturana R,Millar RP

更新日期：2004-10-15 00:00:00

abstract：:KRAS-activating mutations drive human non-small cell lung cancer and initiate lung tumorigenesis in genetically engineered mouse (GEM) models. However, in a GEM model of KRAS(G12D)-induced lung cancer, tumors arise stochastically following a latency period, suggesting that additional events are required to promote ear...

journal_title：Cancer research

authors： Green S,Trejo CL,McMahon M

更新日期：2015-12-15 00:00:00

abstract：:Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed greater than 23-fold differences in cisplatin sensitivities in vitro. Cisplatin resistance in SK-OV-3 cells appeared to be associated with increased levels of g...

journal_title：Cancer research

authors： Shellard SA,Hosking LK,Hill BT

更新日期：1991-09-01 00:00:00

abstract：:We have previously shown that treatment of C57BL/6 mice with specific anti-B16 melanoma monoclonal antibody (Mab) significantly reduced the number of established liver metastases. In this paper we show that when treatment with Mab was applied to mice bearing both liver and lung micrometastases, the number of liver met...

journal_title：Cancer research

authors： Eisenthal A,Cameron RB,Uppenkamp I,Rosenberg SA

更新日期：1988-12-15 00:00:00

abstract：:Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, in...

journal_title：Cancer research

authors： Bussard KM,Siracusa LD

更新日期：2017-11-15 00:00:00

abstract：:Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multip...

journal_title：Cancer research

authors： Judge SM,Deyhle MR,Neyroud D,Nosacka RL,D'Lugos AC,Cameron ME,Vohra RS,Smuder AJ,Roberts BM,Callaway CS,Underwood PW,Chrzanowski SM,Batra A,Murphy ME,Heaven JD,Walter GA,Trevino JG,Judge AR

更新日期：2020-05-01 00:00:00

abstract：:Pancreatic cancer is an aggressive neoplasm with no current viable, effective treatment options. In the majority of cases, at first diagnosis, pancreatic cancer has already become metastatic so that conventional treatment regimens provide minimal, if any, clinical benefit in prolonging life or ameliorating the negativ...

journal_title：Cancer research

authors： Sarkar D,Su ZZ,Vozhilla N,Park ES,Randolph A,Valerie K,Fisher PB

更新日期：2005-10-01 00:00:00

abstract：:Although peptide immunization often leads to the induction of strong T-cell responses, it is seldom effective against established tumors. One possibility is that these T-cell responses are not strong enough or do not last sufficiently long to have an effect in tumor eradication. Here, we examined the role of synthetic...

journal_title：Cancer research

authors： Davila E,Kennedy R,Celis E

更新日期：2003-06-15 00:00:00

abstract：:Genetic alterations that occur in human breast cancers are believed to be of importance for initiation as well as progression of the disease. In order to find a genetic alteration that may be used as a prognostic marker, 82 familial breast carcinomas were analyzed for loss of constitutional heterozygosity at polymorph...

journal_title：Cancer research

authors： Lindblom A,Rotstein S,Skoog L,Nordenskjöld M,Larsson C

更新日期：1993-08-15 00:00:00

abstract：:Chronic myelogenous leukemia is characterized by a specific chromosomal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chimeric BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, whi...

journal_title：Cancer research

authors： ten Hoeve J,Kaartinen V,Fioretos T,Haataja L,Voncken JW,Heisterkamp N,Groffen J

更新日期：1994-05-15 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:The rate of tumor growth in vivo in adult rats (250- to 350-g total body weight) is stimulated during an acute fast. No tumor growth stimulation is observed in fasted immature rats (less than about 200-g total body weight). The different tumor growth responses in rats of these two age groups appear to depend on the in...

journal_title：Cancer research

authors： Sauer LA,Dauchy RT

更新日期：1987-02-15 00:00:00

abstract：:Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206, the first alloste...

journal_title：Cancer research

authors： Cheng Y,Ren X,Zhang Y,Patel R,Sharma A,Wu H,Robertson GP,Yan L,Rubin E,Yang JM

更新日期：2011-04-01 00:00:00

abstract：:A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The CYCLIN D1-TROP2 mRNA was shown to be a potent oncogene as it transforms naïve, primary cells in vitro and induces aggressive tumor growth in vivo in cooperation with activated RAS. Silencing of the chimeric mRNA inhibits the ...

journal_title：Cancer research

authors： Guerra E,Trerotola M,Dell' Arciprete R,Bonasera V,Palombo B,El-Sewedy T,Ciccimarra T,Crescenzi C,Lorenzini F,Rossi C,Vacca G,Lattanzio R,Piantelli M,Alberti S

更新日期：2008-10-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use a rationale-driven approach to identify novel biomarkers for outcome in patient...

journal_title：Cancer research

authors： Colbert LE,Petrova AV,Fisher SB,Pantazides BG,Madden MZ,Hardy CW,Warren MD,Pan Y,Nagaraju GP,Liu EA,Saka B,Hall WA,Shelton JW,Gandhi K,Pauly R,Kowalski J,Kooby DA,El-Rayes BF,Staley CA 3rd,Adsay NV,Curran WJ Jr,

更新日期：2014-05-15 00:00:00

abstract：:Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major mechanisms which lead to tumor acidity probably include the production of lactic acid and hydrolysis of ATP in hypoxic regions of tumors. Further reduction in pH may be achieved in some tumo...

journal_title：Cancer research

authors： Tannock IF,Rotin D

更新日期：1989-08-15 00:00:00

abstract：:Mutations in the human adenomatous polyposis coli (APC) gene are responsible for not only familial adenomatous polyposis but also many sporadic cancers of the digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed Apc gene knockout mice that contained a truncation mutation at ...

journal_title：Cancer research

authors： Oshima H,Oshima M,Kobayashi M,Tsutsumi M,Taketo MM

更新日期：1997-05-01 00:00:00

abstract：:Southern blot-hybridization analysis of DNAs from human tumors demonstrated amplification of the epidermal growth factor (EGF) receptor gene in 10 of 12 squamous cell carcinoma cell lines tested and in none of 18 tumor cell lines of nonsquamous cell carcinomas. The degree of amplification in the squamous cells varied ...

journal_title：Cancer research

authors： Yamamoto T,Kamata N,Kawano H,Shimizu S,Kuroki T,Toyoshima K,Rikimaru K,Nomura N,Ishizaki R,Pastan I

更新日期：1986-01-01 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3,4,5-trisphosphate, to antagonize the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. It has also become increasingly evident ...

journal_title：Cancer research

authors： Gu T,Zhang Z,Wang J,Guo J,Shen WH,Yin Y

更新日期：2011-04-15 00:00:00

abstract：:Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

journal_title：Cancer research

authors： Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

更新日期：2010-09-15 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00

abstract：:Precise diagnosis and subtyping of kidney tumors are imperative to optimize and personalize treatment decision for patients. Patients with the most common benign renal tumor, renal oncocytomas, may be overtreated with surgical resection because of limited preoperative diagnostic methods that can accurately identify th...

journal_title：Cancer research

authors： Zhang J,Li SQ,Lin JQ,Yu W,Eberlin LS

更新日期：2020-02-15 00:00:00

abstract：:gamma-Interferon (IFN-gamma) was shown to amplify cytotoxin release from murine bone marrow-adherent macrophages in response to an animal lectin as a second stimulus. This stimulation of cytotoxin release was demonstrated both in vitro and in vivo and was maximal 2 h after treatment with IFN-gamma. No change in expres...

journal_title：Cancer research

authors： Okutomi T,Yamazaki M

更新日期：1988-04-01 00:00:00

abstract：:EWS encodes a ubiquitously expressed RNA binding protein with largely unknown function. In Ewing sarcoma family tumors (EFT), one allele is rearranged with an ETS gene. This is the first description of an EFT with a complete EWS deficiency in the presence of two copies of a rearranged chromosome 22 carrying an interst...

journal_title：Cancer research

authors： Kovar H,Jug G,Hattinger C,Spahn L,Aryee DN,Ambros PF,Zoubek A,Gadner H

更新日期：2001-08-15 00:00:00

abstract：:Intradermally injected tumor necrosis factor alpha (TNF-alpha) mimics the effects of UV B light (UVB) radiation and neutralizing anti-TNF-alpha antibodies abolish the deleterious effects of UVB on induction of contact hypersensitivity suggesting that TNF-alpha is the major mediator of UVB effects on cutaneous immunity...

journal_title：Cancer research

authors： Vincek V,Kurimoto I,Medema JP,Prieto E,Streilein JW

更新日期：1993-02-15 00:00:00

abstract：:Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leupro...

journal_title：Cancer research

authors： Okada H,Sakura Y,Kawaji H,Yashiki T,Mima H

更新日期：1983-04-01 00:00:00

abstract：:Electron micrographs of CCL237 and FET cells (two slowly growing, differentiated human colon carcinoma lines) revealed enlarged mitochondria with few cristae. Polarographic measurement of respiratory activity in mitochondria isolated from these cell lines was compared to that of CV-1 cells (a normal monkey kidney epit...

journal_title：Cancer research

authors： Modica-Napolitano JS,Steele GD Jr,Chen LB

更新日期：1989-06-15 00:00:00

abstract：:The cadherin family of transmembrane glycoproteins plays a critical role in cell-to-cell adhesion and cadherin dysregulation is strongly associated with cancer metastasis and progression. In this study, we report a novel interaction between protein kinase D1 [PKD1; formerly known as protein kinase C mu (PKCmu)] and E-...

journal_title：Cancer research

authors： Jaggi M,Rao PS,Smith DJ,Wheelock MJ,Johnson KR,Hemstreet GP,Balaji KC

更新日期：2005-01-15 00:00:00