Blood nutrient concentrations and tumor growth in vivo in rats: relationships during the onset of an acute fast.

abstract：:The epithelial mucin MUC1 is overexpressed on the cell surface of many epithelial malignancies as well as on some B-cell lymphomas and multiple myelomas. Recently, we identified two HLA-A2-restricted T-cell epitopes derived from the MUC1 protein. To further extend the potential application of these peptides, we analyz...

journal_title：Cancer research

authors： Brossart P,Schneider A,Dill P,Schammann T,Grünebach F,Wirths S,Kanz L,Bühring HJ,Brugger W

更新日期：2001-09-15 00:00:00

abstract：:Two leukemogenic viral populations were derived from a radiation leukemia virus of the C57BL mouse. One (FB), in which only B-tropic virus could be detected, was obtained in vivo by serial passage of cell-free extract in newborn rats. The second (3C), a complex containing at least B-tropic and xenotropic viruses, was ...

journal_title：Cancer research

authors： Janowski M,Astier T,Guillemain B,Baugnet-Mahieu L,Duplan JF,Maisin JR

更新日期：1978-10-01 00:00:00

abstract：:We have cloned an alternatively spliced form of cyclin-dependent kinase (CDK) inhibitor p15 from human placenta. The alternative splice arises from an alternative 5' donor site in intron 1. An in-frame stop codon within the new exon, called exon 1beta, leads to translation of a Mr 10,000 protein identical to the NH2 t...

journal_title：Cancer research

authors： Tsubari M,Tiihonen E,Laiho M

更新日期：1997-07-15 00:00:00

abstract：:Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases th...

journal_title：Cancer research

authors： Aldaz CM,Gollahon LS,Chen A

更新日期：1993-11-15 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of cytokines regulates cell proliferation, morphogenesis, and specialized cell functions in metazoans. Herein, we screened a compound library for modifiers of TGF-beta signaling in NMuMG epithelial cells using a cell-based assay to measure Smad2/3 nuclear transloca...

journal_title：Cancer research

authors： Park HJ,Partridge E,Cheung P,Pawling J,Donovan R,Wrana JL,Dennis JW

更新日期：2006-04-01 00:00:00

abstract：:A cell line (NCE-G28) was established from the biopsy material of a human gliosarcoma of low histological differentiation. The initial cultures showed a mixed population of cells which in later stages became more uniform due to loss of slower growing constituents. The cells have been growing steadily for 20 months. A ...

journal_title：Cancer research

authors： Westphal M,Haensel M,Mueller D,Laas R,Kunzmann R,Rohde E,Koenig A,Hoelzel F,Herrmann HD

更新日期：1988-02-01 00:00:00

abstract：:A novel putative tumor suppressor gene and member of the NF2/ERM/ 4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung...

journal_title：Cancer research

authors： Tran YK,Bögler O,Gorse KM,Wieland I,Green MR,Newsham IF

更新日期：1999-01-01 00:00:00

abstract：:DNA content and in situ sensitivity to denaturation were analyzed by flow cytometry of individual cell nuclei isolated from 40 breast carcinomas, nine fibroadenomas, and 14 samples of normal breast tissue. The extent of DNA denaturation induced by acid was expressed as alpha t, which represents the fraction of DNA sta...

journal_title：Cancer research

authors： Kunicka JE,Olszewski W,Rosen PP,Kimmel M,Melamed MR,Darzynkiewicz Z

更新日期：1989-11-15 00:00:00

abstract：:Recent studies indicate that ovarian cancer may be highly responsive to antivascular therapeutics. We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loaded nanoparticles (F3-Cis-Np) to tumor vessels. We show that although F3-Cis-Np bind with high specificity to both human ova...

journal_title：Cancer research

authors： Winer I,Wang S,Lee YE,Fan W,Gong Y,Burgos-Ojeda D,Spahlinger G,Kopelman R,Buckanovich RJ

更新日期：2010-11-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:Human p29 is a newly identified nuclear protein whose function is largely undetermined. We found that p29 associated with chromatin, interacted with MCM3, and localized with proliferating cell nuclear antigen foci in the S phase. Silencing of p29 using small interfering RNA duplexes reduced DNA synthesis and increased...

journal_title：Cancer research

authors： Chu PC,Yang YC,Lu YT,Chen HT,Yu LC,Chang MS

更新日期：2006-09-01 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multip...

journal_title：Cancer research

authors： Judge SM,Deyhle MR,Neyroud D,Nosacka RL,D'Lugos AC,Cameron ME,Vohra RS,Smuder AJ,Roberts BM,Callaway CS,Underwood PW,Chrzanowski SM,Batra A,Murphy ME,Heaven JD,Walter GA,Trevino JG,Judge AR

更新日期：2020-05-01 00:00:00

abstract：:The present study was undertaken to investigate the role of plasminogen activator inhibitor type 1 (PAI-1) and activated protein C (APC) in the regulation of tumor cell invasion. PAI-1 was purified in active form from conditioned medium of human umbilical vein endothelial cells under denaturing conditions (4 M guanidi...

journal_title：Cancer research

authors： Kobayashi H,Moniwa N,Gotoh J,Sugimura M,Terao T

更新日期：1994-01-01 00:00:00

abstract：:While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine therapies targeting these receptors often fail. The molecular mechanisms that underlie treatment resistance remain unclear. We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrogen resistance. Hum...

journal_title：Cancer research

authors： Cook KL,Shajahan AN,Wärri A,Jin L,Hilakivi-Clarke LA,Clarke R

更新日期：2012-07-01 00:00:00

abstract：:Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover. Nonetheless, we show here that, in mutant is...

journal_title：Cancer research

authors： Viswanath P,Radoul M,Izquierdo-Garcia JL,Ong WQ,Luchman HA,Cairncross JG,Huang B,Pieper RO,Phillips JJ,Ronen SM

更新日期：2018-05-01 00:00:00

abstract：:The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium expo...

journal_title：Cancer research

authors： Julin B,Wolk A,Bergkvist L,Bottai M,Akesson A

更新日期：2012-03-15 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:The DF3 antigen is a member of a family of high-molecular-weight glycoproteins aberrantly expressed in human breast carcinomas. Recent work has described the generation of a monoclonal antibody (MAb), designated DF3-P, that reacts with immature, underglycosylated precursors of DF3 antigen. Immunoperoxidase staining st...

journal_title：Cancer research

authors： Perey L,Hayes DF,Kufe D

更新日期：1992-11-15 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:Cancers with chromosomal instability (CIN) are held to be aneuploid/polyploid with multiple large-scale gains/deletions, but the processes underlying CIN are unclear and different types of CIN might exist. We investigated colorectal cancer cell lines using array-comparative genomic hybridization (CGH) for copy number ...

journal_title：Cancer research

authors： Gaasenbeek M,Howarth K,Rowan AJ,Gorman PA,Jones A,Chaplin T,Liu Y,Bicknell D,Davison EJ,Fiegler H,Carter NP,Roylance RR,Tomlinson IP

更新日期：2006-04-01 00:00:00

abstract：:Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of epithelial differentiation. They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positi...

journal_title：Cancer research

authors： Ladanyi M,Antonescu CR,Leung DH,Woodruff JM,Kawai A,Healey JH,Brennan MF,Bridge JA,Neff JR,Barr FG,Goldsmith JD,Brooks JS,Goldblum JR,Ali SZ,Shipley J,Cooper CS,Fisher C,Skytting B,Larsson O

更新日期：2002-01-01 00:00:00

abstract：:The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by co...

journal_title：Cancer research

authors： Zhong LT,Manzi A,Skowronski E,Notterpek L,Fluharty AL,Faull KF,Masada I,Rabizadeh S,Varsanyi-Nagy M,Ruan Y,Oh JD,Butcher LL,Bredesen DE

更新日期：2001-08-01 00:00:00

abstract：:ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. To determine whether N-glycosylation is involved in the functi...

journal_title：Cancer research

authors： Yokoe S,Takahashi M,Asahi M,Lee SH,Li W,Osumi D,Miyoshi E,Taniguchi N

更新日期：2007-03-01 00:00:00

abstract：:The transcription factor NF-E2-related factor 2 (Nrf2) binds the antioxidant DNA response element (ARE) to activate important cellular cytoprotective defense systems. Recently several types of cancers have been shown to overexpress Nrf2, but its role in the cellular response to radiation therapy has yet to be fully de...

journal_title：Cancer research

authors： McDonald JT,Kim K,Norris AJ,Vlashi E,Phillips TM,Lagadec C,Della Donna L,Ratikan J,Szelag H,Hlatky L,McBride WH

更新日期：2010-11-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation...

journal_title：Cancer research

authors： Yamauchi Y,Kodama Y,Shiokawa M,Kakiuchi N,Marui S,Kuwada T,Sogabe Y,Tomono T,Mima A,Morita T,Matsumori T,Ueda T,Tsuda M,Nishikawa Y,Kuriyama K,Sakuma Y,Ota Y,Maruno T,Uza N,Masuda A,Tatsuoka H,Yabe D,Minamiguc

更新日期：2020-09-01 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00