Abstract:
:gamma-Interferon (IFN-gamma) was shown to amplify cytotoxin release from murine bone marrow-adherent macrophages in response to an animal lectin as a second stimulus. This stimulation of cytotoxin release was demonstrated both in vitro and in vivo and was maximal 2 h after treatment with IFN-gamma. No change in expression of surface antigens was detected on bone marrow-adherent cells treated with IFN-gamma. IFN-gamma also augmented production of cytotoxin from bone marrow-adherent cells that had been cultured for several days. This cytotoxin was inhibited by rabbit anti-tumor necrosis factor serum and had a molecular weight of 70,000. These findings showed that both freshly isolated and cultured bone marrow macrophages could release cytotoxin and that cytotoxin production in response to a second stimulus was augmented by IFN-gamma. The results also suggest that IFN-gamma can activate all macrophages in vivo, irrespective of their states of maturation and differentiation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Okutomi T,Yamazaki Msubject
Has Abstractpub_date
1988-04-01 00:00:00pages
1808-11issue
7eissn
0008-5472issn
1538-7445journal_volume
48pub_type
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