Regulation of glucocorticoid receptor protein and mRNA levels.

abstract：:CD26 is an antigen with key role in T-cell biology and is expressed on selected subsets of aggressive T-cell malignancies. To elucidate the role of CD26 in tumor behavior, we examine the effect of CD26 depletion by small interfering RNA transfection of T-anaplastic large cell lymphoma Karpas 299. We show that the resu...

journal_title：Cancer research

authors： Sato T,Yamochi T,Yamochi T,Aytac U,Ohnuma K,McKee KS,Morimoto C,Dang NH

更新日期：2005-08-01 00:00:00

abstract：:The local growth rate of Morris Hepatoma 44 (generation time, 6 months) was inhibited by 66 to 87%, and host survival was prolonged by 36 to 78% after the induction of hypothyroidism within 2 weeks of tumor implantation by propylthiouracil (0.1% in Purina chow), 131I(1 mCi/100 g body weight i.p.), or surgical thyroide...

journal_title：Cancer research

authors： Mishkin SY,Pollack R,Yalovsky MA,Morris HP,Mishkin S

更新日期：1981-08-01 00:00:00

abstract：:We describe two flow cytometric assays performed on populations of cells which have been stained with various fluorescent tracer molecules by the scrape-loading technique. One assay uses a simple one-color analysis on a flow cytometer by quantitating the fluorescence intensity of scrape-loaded lucifer yellow CH (LY) i...

journal_title：Cancer research

authors： Kavanagh TJ,Martin GM,el-Fouly MH,Trosko JE,Chang CC,Rabinovitch PS

更新日期：1987-11-15 00:00:00

abstract：:Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of direct action of bisphosphonates on bone have been limited mainly to their effects on bone-resorbing osteoclast cells, wit...

journal_title：Cancer research

authors： Reinholz GG,Getz B,Pederson L,Sanders ES,Subramaniam M,Ingle JN,Spelsberg TC

更新日期：2000-11-01 00:00:00

abstract：:Both activating and inactivating mutations in protein tyrosine phosphatase Ptpn11 (encoding Shp2) are associated with tumorigenesis. However, the underlying mechanisms remain unclear. Here, we show that Shp2 plays an important role in mitosis, dysregulation of which results in chromosome instability and cancer predisp...

journal_title：Cancer research

authors： Liu X,Zheng H,Qu CK

更新日期：2012-10-15 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with un...

journal_title：Cancer research

authors： Drummond DC,Noble CO,Guo Z,Hong K,Park JW,Kirpotin DB

更新日期：2006-03-15 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7, and 9 that regulate the cell cycle and transcription. Our studies in indolent primary chronic lymphocytic leukemia cells showed that SNS-032 inhibited transcription, diminished the antiapoptotic protein Mcl-1, and induced apoptosis. The present stud...

journal_title：Cancer research

authors： Chen R,Chubb S,Cheng T,Hawtin RE,Gandhi V,Plunkett W

更新日期：2010-08-15 00:00:00

abstract：:The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

journal_title：Cancer research

authors： Howard RA,Spring TG,Bear JL

更新日期：1976-12-01 00:00:00

abstract：:Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV1...

journal_title：Cancer research

authors： Cheng YW,Wu MF,Wang J,Yeh KT,Goan YG,Chiou HL,Chen CY,Lee H

更新日期：2007-11-15 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:Mice bearing the immunosuppressive plasmacytoma TEPC-183 exhibit a marked splenic hyperplasia. We have characterized these tumor-reactive splenocytes on the basis of cell surface marker expression, nonspecific esterase activity, and morphology. Although splenocyte numbers increased progressively throughout tumor growt...

journal_title：Cancer research

authors： Shanahan TC,Ceglowski WS,Havas HF

更新日期：1985-12-01 00:00:00

abstract：:Upon incubation of cultured mammalian cells with the new anthracycline analogues cyanomorpholinyldoxorubicin and morpholinyldoxorubicin, nucleoli irreversibly segregate into their substructures which form individual portions of the nucleolar mass and characteristic electron-dense components adjacent to the nucleolonem...

journal_title：Cancer research

authors： Wassermann K,Newman RA,Davis FM,Mullins TD,Rose KM

更新日期：1988-07-15 00:00:00

abstract：:The cytokine-inducible endothelial cell adhesion receptor E-selectin has been implicated in cancer metastasis. Previously, we reported that experimental liver metastasis of Lewis lung carcinoma subline H-59 cells could be abrogated in animals treated with an anti-E-selectin antibody. To gain further insight into the f...

journal_title：Cancer research

authors： Khatib AM,Kontogiannea M,Fallavollita L,Jamison B,Meterissian S,Brodt P

更新日期：1999-03-15 00:00:00

abstract：:The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) w...

journal_title：Cancer research

authors： Ann EJ,Kim MY,Yoon JH,Ahn JS,Jo EH,Lee HJ,Lee HW,Kang HG,Choi DW,Chun KH,Lee JS,Choi CY,Ferrando AA,Lee K,Park HS

更新日期：2016-08-15 00:00:00

abstract：:An antigen(s) on the surface of embryonic and newly hatched chick red blood cells was studied with antiserum absorbed with adult red blood cells. Because of the reappearance of the antigen or some cross-reactive antigen during myeloblastosis, attempts at solubilization and characterization of the antigen were pursued....

journal_title：Cancer research

authors： O'Brien TJ,Teplitz RL

更新日期：1978-04-01 00:00:00

abstract：:miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR...

journal_title：Cancer research

authors： Fan S,Tian T,Chen W,Lv X,Lei X,Zhang H,Sun S,Cai L,Pan G,He L,Ou Z,Lin X,Wang X,Perez MF,Tu Z,Ferrone S,Tannous BA,Li J

更新日期：2019-03-15 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) are effective in suppressing the formation of colorectal tumors. However, the mechanisms underlying the antineoplastic effects of NSAIDs remain unclear. The effects of NSAIDs are incomplete, and resistance to NSAIDs is often developed. Growing evidence has indicated that th...

journal_title：Cancer research

authors： Bank A,Wang P,Du C,Yu J,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Combination treatment of SKCO1 human colon carcinoma cells with beta ser-interferon (IFN-beta ser) and gamma-interferon (IFN-gamma) results in a synergistic antiproliferative effect. The role of IFN-beta ser and IFN-gamma receptor modulation was investigated as a possible mechanism for this response. IFN-gamma (0.05-5...

journal_title：Cancer research

authors： Schiller JH,Bushmeyer SM,Ruzicka FJ,Princler GL,Faltynek CR,Borden EC

更新日期：1990-01-01 00:00:00

abstract：:Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial dysplasia would identify cellular processes that underlie progressio...

journal_title：Cancer research

authors： Merrick DT,Edwards MG,Franklin WA,Sugita M,Keith RL,Miller YE,Friedman MB,Dwyer-Nield LD,Tennis MA,O'Keefe MC,Donald EJ,Malloy JM,van Bokhoven A,Wilson S,Koch PJ,O'Shea C,Coldren C,Orlicky DJ,Lu X,Baron AE,Hickey

更新日期：2018-09-01 00:00:00

abstract：:A deletion in an Alu repetitive sequence in the fifth intron of the c-sis gene of meningioma patients was previously described (M. Smidt et al., J. Clin. Invest., 86:1151-1157, 1990). The authors analyzed the structure of this intron in DNA from peripheral blood leukocytes and tumor samples of 86 patients with sporadi...

journal_title：Cancer research

authors： Smidt M,Dumanski JP,Collins VP,Ratner L

更新日期：1991-08-15 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple GBM cell subpopulations could be purified from the specimens o...

journal_title：Cancer research

authors： Mazzoleni S,Politi LS,Pala M,Cominelli M,Franzin A,Sergi Sergi L,Falini A,De Palma M,Bulfone A,Poliani PL,Galli R

更新日期：2010-10-01 00:00:00

abstract：:The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highly expressed in metastatic breast cancer-derived cell lines but not in the nonmetastatic estrogen-dependent MCF-7 cells. Furthermo...

journal_title：Cancer research

authors： Akiri G,Sabo E,Dafni H,Vadasz Z,Kartvelishvily Y,Gan N,Kessler O,Cohen T,Resnick M,Neeman M,Neufeld G

更新日期：2003-04-01 00:00:00

abstract：:Previous studies have shown that all-trans-retinoic acid fails to inhibit chemically induced transformation in 10T1/2 cells except at toxic levels, whereas retinol and many synthetic retinoids are potent inhibitors. In contrast, in many systems retinoic acid is a more effective modulator of differentiation and carcino...

journal_title：Cancer research

authors： Rundhaug J,Gubler ML,Sherman MI,Blaner WS,Bertram JS

更新日期：1987-11-01 00:00:00

abstract：:Thirty-one patients with metastatic hormone-refractory prostatic adenocarcinoma were investigated scintigraphically with the 111In-labeled somatostatin analogue [DTPA-D-Phe1]-octreotide (OctreoScan) and with 99mTc-labeled HDP. In vitro somatostatin receptor autoradiography was performed on biopsies obtained from eight...

journal_title：Cancer research

authors： Nilsson S,Reubi JC,Kalkner KM,Laissue JA,Horisberger U,Olerud C,Westlin JE

更新日期：1995-12-01 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:Unlike the growth factor dependence of normal cells, cancer cells can maintain growth factor-independent glycolysis and survival through expression of oncogenic kinases, such as BCR-Abl. Although targeted kinase inhibition can promote cancer cell death, therapeutic resistance develops frequently, and further mechanist...

journal_title：Cancer research

authors： Mason EF,Zhao Y,Goraksha-Hicks P,Coloff JL,Gannon H,Jones SN,Rathmell JC

更新日期：2010-10-15 00:00:00