SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release.

abstract：:One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood...

journal_title：Cancer research

authors： Moreno CS,Ramachandran S,Ashby DG,Laycock N,Plattner CA,Chen W,Hahn WC,Pallas DC

更新日期：2004-10-01 00:00:00

abstract：:This study investigates possible alterations in exons 5 through 8 of the p53 gene and altered p53 protein expression in the Syrian golden hamster model of pancreatic ductal adenocarcinoma. In the Syrian hamster p53 sequence, 1469 base pairs are presented for the genomic regions surrounding exons 5 through 8, along wit...

journal_title：Cancer research

authors： Chang KW,Mangold KA,Hubchak S,Laconi S,Scarpelli DG

更新日期：1994-07-15 00:00:00

abstract：:LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tissues inside tumor sites and recruits naïve T cells into the tumor. However, whether these infiltrating T cells are specific for tumor antigens is not known. We hypothesized that therapy with LIGHT can expand functional tumor-specific CD8(+...

journal_title：Cancer research

authors： Kanodia S,Da Silva DM,Karamanukyan T,Bogaert L,Fu YX,Kast WM

更新日期：2010-05-15 00:00:00

abstract：:When the human cell line NHIK 3025 was exposed to retinoic acid (1 nM; 10 microM), the cell cycle time was prolonged. Experiments using cells synchronized by mitotic selection showed that the retinoic acid induced growth delay was barely seen within the first cell cycle after exposure to 10 microM retinoic acid, where...

journal_title：Cancer research

authors： Bakke O

更新日期：1986-03-01 00:00:00

abstract：:In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes as were observed to increase, suggesting a previously unknown mechanism for epigenetic regulation. To address this idea, the expression of the BAG family genes...

journal_title：Cancer research

authors： Sun L,Huang L,Nguyen P,Bisht KS,Bar-Sela G,Ho AS,Bradbury CM,Yu W,Cui H,Lee S,Trepel JB,Feinberg AP,Gius D

更新日期：2008-04-15 00:00:00

abstract：:The acute hemorrhagic necrosis of tumor nodules caused by the systemic administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) has been partially attributed to changes in tumor neovascularity. In this study, the effects of rhTNF-alpha were tested on primary autochthonous sarcomas induced in C57BL...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Travis WD,Rosenberg SA

更新日期：1990-04-15 00:00:00

abstract：:Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases th...

journal_title：Cancer research

authors： Aldaz CM,Gollahon LS,Chen A

更新日期：1993-11-15 00:00:00

abstract：:The distribution in human tissues has been determined of the new DNA polymerase activity designated DNA polymerase Cm, first isolated from the human melanoma cell line A-375. Tissue samples were fractionated by ion exchange chromatography on diethylaminoethyl cellulose and phosphocellulose and by affinity chromatograp...

journal_title：Cancer research

authors： Loewenstein PM,Lange GW,Gerard GF

更新日期：1980-12-01 00:00:00

abstract：:The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. Using viable cell membrane immunofluorescence, most established and early passage...

journal_title：Cancer research

authors： Cloyd MW,Bolognesi DP,Bigner DD

更新日期：1977-03-01 00:00:00

abstract：:We have studied the sensitivities of four hematopoietic stem cell types to heat stress as well as their abilities to develop thermotolerance. Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. Of the erythroid progenitors tested, erythrocyte colony forming units we...

journal_title：Cancer research

authors： Mivechi NF,Li GC

更新日期：1986-01-01 00:00:00

abstract：:We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits proliferation of cancer cell lines from various organs and tissues at nanomolar concentrations. Its IC(50) value ranges from 4.1 to 50 nmol/L. The...

journal_title：Cancer research

authors： Zhang LH,Wu L,Raymon HK,Chen RS,Corral L,Shirley MA,Narla RK,Gamez J,Muller GW,Stirling DI,Bartlett JB,Schafer PH,Payvandi F

更新日期：2006-01-15 00:00:00

abstract：:Recent studies demonstrated that the resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) could be reversed by various chemotherapeutic agents. In the present study, we investigated the role of Akt in the apoptosis resistance to TRAIL and chemotherapeutic agents-induced TRAIL s...

journal_title：Cancer research

authors： Asakuma J,Sumitomo M,Asano T,Asano T,Hayakawa M

更新日期：2003-03-15 00:00:00

abstract：:The bilirubin-binding ability of human alpha-fetoproteins, which were purified from fetal cord serum and from ascites fluid of a hepatoma-bearing patient, was examined by the difference spectrum and the Jacobsen peroxidase methods. The difference spectrum observed as a result of the specific binding of bilirubin to al...

journal_title：Cancer research

authors： Aoyagi Y,Ikenaka T,Ichida F

更新日期：1979-09-01 00:00:00

abstract：:Docetaxel tolerance and antitumor efficacy could be enhanced if drug administration was adapted to circadian rhythms. This hypothesis was investigated in seven experiments involving a total of 626 male B6D2F1 mice, synchronized with an alternation of 12 h of light and 12 h of darkness (12:12), after i.v. administratio...

journal_title：Cancer research

authors： Tampellini M,Filipski E,Liu XH,Lemaigre G,Li XM,Vrignaud P,François E,Bissery MC,Lévi F

更新日期：1998-09-01 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:In vivo studies have shown that inhibitors of cyclooxygenase metabolism of arachidonic acid may diminish growth and metastasis of certain tumors. Because cyclooxygenase inhibition may increase the production of lipoxygenase products of arachidonic acid metabolism, we have investigated the effect of two such products, ...

journal_title：Cancer research

authors： Werner EJ,Walenga RW,Dubowy RL,Boone S,Stuart MJ

更新日期：1985-02-01 00:00:00

abstract：:In order to investigate the early cellular changes in liver associated with furan cholangiocarcinogenesis, young adult male Fischer 344 rats were administered furan by gavage once a day, 5 days a wk for 2 to 3 wk at doses ranging from 15 to 60 mg/kg of body weight per day. The most conspicuous feature observed in the ...

journal_title：Cancer research

authors： Elmore LW,Sirica AE

更新日期：1991-10-15 00:00:00

abstract：:The Notch family of proteins plays an integral role in determining cell fates, such as proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. Immunohistochemistry of a primary human glioma ti...

journal_title：Cancer research

authors： Purow BW,Haque RM,Noel MW,Su Q,Burdick MJ,Lee J,Sundaresan T,Pastorino S,Park JK,Mikolaenko I,Maric D,Eberhart CG,Fine HA

更新日期：2005-03-15 00:00:00

abstract：:The asymmetric organization of epithelial cells is a basic counter to cellular proliferation. However, the mechanisms whereby pro-growth pathways are modulated by intracellular factors that control cell shape are not well understood. This study demonstrates that the adaptor protein Amot, in addition to its established...

journal_title：Cancer research

authors： Ranahan WP,Han Z,Smith-Kinnaman W,Nabinger SC,Heller B,Herbert BS,Chan R,Wells CD

更新日期：2011-03-15 00:00:00

abstract：:Traditionally, non-small cell lung cancer (NSCLC) has been evaluated as a unique entity in genotyping studies. However, recent biological data suggest that different NSCLC subtypes, specifically adenocarcinomas (AC) and squamous cell carcinomas (SCC), differentially alter cancer behavior. Several studies have associat...

journal_title：Cancer research

authors： Liu G,Miller DP,Zhou W,Thurston SW,Fan R,Xu LL,Lynch TJ,Wain JC,Su L,Christiani DC

更新日期：2001-12-15 00:00:00

abstract：:Although peptide immunization often leads to the induction of strong T-cell responses, it is seldom effective against established tumors. One possibility is that these T-cell responses are not strong enough or do not last sufficiently long to have an effect in tumor eradication. Here, we examined the role of synthetic...

journal_title：Cancer research

authors： Davila E,Kennedy R,Celis E

更新日期：2003-06-15 00:00:00

abstract：:The association between total serum cholesterol and triglycerides and the incidence rate of breast cancer has been examined in 242 incident cases of breast cancer that developed among 24,329 Norwegian women during 11-14 years of follow-up. At the time of lipid measurement they were between 35 and 51 years of age. Ther...

journal_title：Cancer research

authors： Vatten LJ,Foss OP

更新日期：1990-04-15 00:00:00

abstract：:Children with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas. The NF1 gene product, neurofibromin, functions as a negative regulator of RAS, such that NF1 inactivation results in RAS hyperactivation. Recent studies have highlighted the divergent biological and biochemical p...

journal_title：Cancer research

authors： Dasgupta B,Li W,Perry A,Gutmann DH

更新日期：2005-01-01 00:00:00

abstract：:An estrogen-responsive mouse Leydig cell tumor line (Tumor 124958) has been shown to contain only a low-affinity binder for estradiol in the cytosol fraction. This differed from the putative estrogen receptor in terms of its hormone-binding specificity as well as affinity. In addition, the possibility that an estrogen...

journal_title：Cancer research

authors： Maeda Y,Sato B,Noma K,Kishimoto S,Koizumi K,Aono T,Matsumoto K

更新日期：1983-09-01 00:00:00

abstract：:Growth factors play an important role in regulating neural stem cell proliferation and differentiation. This study shows that platelet-derived growth factor (PDGF) induces a partial differentiation of neural stem/progenitor cells (NSPCs) in the absence of other mitogens in vitro. NSPCs thus acquire an immature morphol...

journal_title：Cancer research

authors： Erlandsson A,Brännvall K,Gustafsdottir S,Westermark B,Forsberg-Nilsson K

更新日期：2006-08-15 00:00:00

abstract：:Pregnancy and development are known to modify carcinogenesis. Little is known about the mechanism for the modulation. These studies investigated the relative sensitivity of nonpregnant, pregnant, and fetal mice to the induction of covalent DNA modifications and micronucleated erythrocytes by 4-nitroquinoline 1-oxide (...

journal_title：Cancer research

authors： Lu LJ,Baxter JR,Wang MY,Harper BL,Tasaka F,Kohda K

更新日期：1990-10-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:The interaction of the antiestrogen tamoxifen (Tx) with calmodulin (CaM) was investigated by cross-linking between the protein and [3H] tamoxifen aziridine. We observed that CaM binds Tx in a Ca2(+)-dependent manner and that two components are involved in the binding, with apparent dissociation constants (Kd) of about...

journal_title：Cancer research

authors： Lopes MC,Vale MG,Carvalho AP

更新日期：1990-05-01 00:00:00

abstract：:The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is the isotropic stress exerted by the fluid phase. We recently showed that growth-induced solid str...

journal_title：Cancer research

authors： Stylianopoulos T,Martin JD,Snuderl M,Mpekris F,Jain SR,Jain RK

更新日期：2013-07-01 00:00:00

abstract：:A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detectin...

journal_title：Cancer research

authors： Nakajima T,Sano K,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2012-09-15 00:00:00