CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.

abstract：:Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors derived from gluconeogenic tissues including liver and kidney, yet the definitive regulatory mechanism remains elusive. Here, we screened an array of transcription regulators and identified the enhancer of zeste homolog 2 (EZH2) as a...

journal_title：Cancer research

authors： Liao K,Deng S,Xu L,Pan W,Yang S,Zheng F,Wu X,Hu H,Liu Z,Luo J,Zhang R,Kuang DM,Dong J,Wu Y,Zhang H,Zhou P,Bei JX,Xu Y,Ji Y,Wang P,Ju HQ,Xu RH,Li B

更新日期：2020-02-15 00:00:00

abstract：:We have investigated the effect of a combined chemoimmunotherapy protocol with liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE), 5-fluorouracil (5-FU), and 5-formyltetrahydrofolate (leucovorin) on the growth of hepatic metastases using carcinoma H-59, a liver-homing subline of the Lewis lung carcinoma (P...

journal_title：Cancer research

authors： Asao T,Shibata HR,Batist G,Brodt P

更新日期：1992-11-15 00:00:00

abstract：:Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

journal_title：Cancer research

authors： Ewig RA,Kohn KW

更新日期：1978-10-01 00:00:00

abstract：:To identify the possible role of calcium ions in cell differentiation, we studied the extracellular Ca2+ requirement and the effect of Ca2+/phospholipid-dependent protein kinase (protein kinase C) inhibitor on proliferation and differentiation of human promyelocytic leukemic HL-60 cells. HL-60 cells grew equally well ...

journal_title：Cancer research

authors： Matsui T,Nakao Y,Koizumi T,Katakami Y,Fujita T

更新日期：1986-02-01 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:One of the greatest challenges in developing therapeutic regimens is the inability to rapidly and objectively assess tumor response due to treatment. Moreover, tumor response to therapeutic intervention in many cases is transient, and progressive alterations within the tumor may mask the effectiveness of an initially ...

journal_title：Cancer research

authors： Lee KC,Hall DE,Hoff BA,Moffat BA,Sharma S,Chenevert TL,Meyer CR,Leopold WR,Johnson TD,Mazurchuk RV,Rehemtulla A,Ross BD

更新日期：2006-05-01 00:00:00

abstract：:After 16 months, an established line of human small cell lung cancer (OH-1) underwent a subtle morphological change which was associated with a virtually complete loss of neuroendocrine differentiation as judged by electron microscopy studies and a 12-fold loss in L-dopa decarboxylase activity. In nude (athymic) mouse...

journal_title：Cancer research

authors： Goodwin G,Baylin SB

更新日期：1982-04-01 00:00:00

abstract：:Photodynamic therapy (PDT) clinical results are promising; however, tumor recurrences can occur and, therefore, methods for improving treatment efficacy are needed. PDT elicits direct tumor cell death and microvascular injury as well as expression of angiogenic, inflammatory, and prosurvival molecules. Preclinical stu...

journal_title：Cancer research

authors： Ferrario A,Chantrain CF,von Tiehl K,Buckley S,Rucker N,Shalinsky DR,Shimada H,DeClerck YA,Gomer CJ

更新日期：2004-04-01 00:00:00

abstract：:Although regulatory T cells (Tregs) have been detected in clinically apparent and experimentally induced tumors, the significance of their presence is obscured because past studies examined late-stage tumors that had formed in immunocompetent hosts and thus had evolved mechanisms to escape immunologic recognition and/...

journal_title：Cancer research

authors： Bui JD,Uppaluri R,Hsieh CS,Schreiber RD

更新日期：2006-07-15 00:00:00

abstract：:2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A) is a new deoxyadenosine analogue that is resistant to phosphorolytic cleavage and deamination. Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) i...

journal_title：Cancer research

authors： Xie C,Plunkett W

更新日期：1995-07-01 00:00:00

abstract：:Major surgery impairs the cellular immune response. We have therefore studied the immunological effects of low-dose recombinant interleukin 2 given to patients undergoing surgery for colorectal cancer to determine whether this agent has potential in perioperative adjuvant immunotherapy. Patients were randomly allocate...

journal_title：Cancer research

authors： Nichols PH,Ramsden CW,Ward U,Sedman PC,Primrose JN

更新日期：1992-10-15 00:00:00

abstract：:Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the first site to be colonized by neoplastic cells that metastasize. To investigate how the presence of neoplastic cells in sentinel lymph nodes may trigger pathways associated with metastatic progression, we analyzed the trans...

journal_title：Cancer research

authors： Vallacchi V,Vergani E,Camisaschi C,Deho P,Cabras AD,Sensi M,De Cecco L,Bassani N,Ambrogi F,Carbone A,Crippa F,Vergani B,Frati P,Arienti F,Patuzzo R,Villa A,Biganzoli E,Canevari S,Santinami M,Castelli C,Rivoltini L

更新日期：2014-01-01 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:B7-H3, a surface immunomodulatory glycoprotein, inhibits natural killer cells and T cells. The monoclonal antibody (mAb) 8H9 is specific for 4Ig-B7-H3, the long and principal form of B7-H3. Early results from radioimmunotherapy using 8H9 have shown promise in patients with metastatic solid tumors to the central nervou...

journal_title：Cancer research

authors： Xu H,Cheung IY,Guo HF,Cheung NK

更新日期：2009-08-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with 11q23 translocations is usually associated with MLL gene rearrangement, but little is known about its leukemogenesis. We analyzed the gene expression profiles of pediatric ALL samples according to their translocations. Using oligonucleotide microarray analysis, we identified dis...

journal_title：Cancer research

authors： Tsutsumi S,Taketani T,Nishimura K,Ge X,Taki T,Sugita K,Ishii E,Hanada R,Ohki M,Aburatani H,Hayashi Y

更新日期：2003-08-15 00:00:00

abstract：:We have demonstrated previously that there is a marked decrease in the level of labeled fucose incorporated into an amino acid fucoside, i.e., fucosyl-N-acetylglucosaminylasparagine (FL4c) in SV40-transformed human embryonic lung cells (SV40-WI-38) as compared to WI-38 cells (Morton, P.A., Klinger, M. M., and Steiner,...

journal_title：Cancer research

authors： Steiner SM,Morton PA

更新日期：1984-10-01 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine therapies targeting these receptors often fail. The molecular mechanisms that underlie treatment resistance remain unclear. We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrogen resistance. Hum...

journal_title：Cancer research

authors： Cook KL,Shajahan AN,Wärri A,Jin L,Hilakivi-Clarke LA,Clarke R

更新日期：2012-07-01 00:00:00

abstract：:The outcome of patients with advanced stage rhabdomyosarcoma is extremely poor, with a disease-free survival of less than 20% at 3 years. Autologous bone marrow transplantation for patients with Clinical Group IV rhabdomyosarcoma may be an effective therapy. The bone marrow involvement diagnosed by light microscopy is...

journal_title：Cancer research

authors： Ozkaynak MF,Nolta J,Parkman R

更新日期：1990-03-01 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:We compared the effect of nine N-nitroso compounds, given by gavage to adult rats, on specific radioactivity of the trichloroacetic acid-precipitable liver proteins, 1 hr after the injection of [14C]leucine. The specific radioactivity was decreased by dimethylnitrosamine, diethylnitrosamine, methyl-n-butylnitrosamine,...

journal_title：Cancer research

authors： Chu C,Mirvish SS

更新日期：1977-05-01 00:00:00

abstract：:We have developed a model system which can be utilized for characterizing both the molecular basis of natural killer (NK):tumor interactions and the consequences of these interactions on tumor growth in vivo. This model system consists of several tumor lines which were derived from the murine lymphoma ASL1w under cond...

journal_title：Cancer research

authors： Smithson G,Wolcott RM,Chervenak R

更新日期：1992-08-01 00:00:00

abstract：:The relative contribution of lymphocytes, macrophages, and granulocytes to the cell content of primary 3-methyl-cholanthrene-induced murine fibrosarcomas was determined at different stages in their progression by differential cell analysis on enzyme-derived single-cell suspensions. Furthermore, immunohistological anal...

journal_title：Cancer research

authors： Wood GW,Gollahon KA

更新日期：1978-07-01 00:00:00

abstract：:Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, the role of GLK in cancer recurrence remains unclear. Here, we report that transgenic GLK promotes tumor metastasis and cell migration through the scaffold protein IQ motif-containin...

journal_title：Cancer research

authors： Chuang HC,Chang CC,Teng CF,Hsueh CH,Chiu LL,Hsu PM,Lee MC,Hsu CP,Chen YR,Liu YC,Lyu PC,Tan TH

更新日期：2019-10-01 00:00:00

abstract：:The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients were each given, sequentially, the racemate, the (+)-enantiomer, and its (-)-antipode. The plasma levels of parent drug and the urinary output (24 hr) of unchanged drug and of two enzymatica...

journal_title：Cancer research

authors： Jarman M,Milsted RA,Smyth JF,Kinas RW,Pankiewicz K,Stec WJ

更新日期：1979-07-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type I (HTLV-I) is characterized by poor prognosis after chemotherapy. Recent clinical trials have indicated, however, that allogeneic but not autologous hematopoietic stem cell transplantation (HSCT) for ATL can yield better clinical outcomes. In the p...

journal_title：Cancer research

authors： Harashima N,Kurihara K,Utsunomiya A,Tanosaki R,Hanabuchi S,Masuda M,Ohashi T,Fukui F,Hasegawa A,Masuda T,Takaue Y,Okamura J,Kannagi M

更新日期：2004-01-01 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigen expression in neuroblastoma may play a role in the oncogenicity of this embryonal tumor of childhood. Since N-myc amplification in neuroblastoma tumors is associated with rapid tumor progression (33) and N-myc decreases Class I MHC antigen expression in rat neurob...

journal_title：Cancer research

authors： Cooper MJ,Hutchins GM,Mennie RJ,Israel MA

更新日期：1990-06-15 00:00:00

abstract：:A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was initiated; over 200 derivatives were synthesized and tested for antican...

journal_title：Cancer research

authors： Dexter DL,Hesson DP,Ardecky RJ,Rao GV,Tippett DL,Dusak BA,Paull KD,Plowman J,DeLarco BM,Narayanan VL

更新日期：1985-11-01 00:00:00

abstract：:The potential to heighten the efficacy of antiangiogenic agents was explored in this study based on active targeting of tumor cells overexpressing the gonadotropin-releasing hormone receptor (GnRH-R). The rational design pursued focused on five analogues of a clinically established antiangiogenic compound (sunitinib),...

journal_title：Cancer research

authors： Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

更新日期：2016-03-01 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00