Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis.

abstract：:Forestomach papillomas and skin papillomas were induced very efficiently by a single dose administration of the chemical carcinogen methylnitrosourea (MNU) in transgenic mice (rasH2 line) carrying human hybrid c-Ha-ras genes, which encode the prototype p21 gene product. The incidence of forestomach papillomas was dose...

journal_title：Cancer research

authors： Ando K,Saitoh A,Hino O,Takahashi R,Kimura M,Katsuki M

更新日期：1992-02-15 00:00:00

abstract：:Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene reporter expression with high specificity in small intestinal goblet ce...

journal_title：Cancer research

authors： Gum JR Jr,Hicks JW,Gillespie AM,Rius JL,Treseler PA,Kogan SC,Carlson EJ,Epstein CJ,Kim YS

更新日期：2001-04-15 00:00:00

abstract：:Androgen receptors (ARs) belong to the family of hormone receptors that are ligand-dependent transcription factors. Endocrine therapy provides effective treatment for prostate cancer until mutations arise that alter the ligand responsiveness of AR. In this study, structural models were developed for the functional dom...

journal_title：Cancer research

authors： McDonald S,Brive L,Agus DB,Scher HI,Ely KR

更新日期：2000-05-01 00:00:00

abstract：:Gastrointestinal adenocarcinomas (GIAC) of the tubular gastrointestinal (GI) tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer...

journal_title：Cancer research

authors： Pan J,Silva TC,Gull N,Yang Q,Plummer JT,Chen S,Daigo K,Hamakubo T,Gery S,Ding LW,Jiang YY,Hu S,Xu LY,Li EM,Ding Y,Klempner SJ,Gayther SA,Berman BP,Koeffler HP,Lin DC

更新日期：2020-07-01 00:00:00

abstract：:TNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNF-α) or a soluble 17-kDa cytokine (sTNF-α), the vast majority of pub...

journal_title：Cancer research

authors： Ardestani S,Li B,Deskins DL,Wu H,Massion PP,Young PP

更新日期：2013-07-01 00:00:00

abstract：:In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were treated by s.c. bolus once a day. However, it was not clear in the previo...

journal_title：Cancer research

authors： Kisker O,Becker CM,Prox D,Fannon M,D'Amato R,Flynn E,Fogler WE,Sim BK,Allred EN,Pirie-Shepherd SR,Folkman J

更新日期：2001-10-15 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:Single-chain Fv antibody fragments from the CD20-specific murine monoclonal antibody B9E9 were genetically engineered as streptavidin fusions [single-chain Fv-streptavidin (scFvSA) fusion protein] for use in pretargeted radioimmunotherapy. The scFvSA constructs were expressed as soluble, tetrameric species in the peri...

journal_title：Cancer research

authors： Schultz J,Lin Y,Sanderson J,Zuo Y,Stone D,Mallett R,Wilbert S,Axworthy D

更新日期：2000-12-01 00:00:00

abstract：:Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed in human cancer. Here, we report the development of 3 unique c-myc knock-in mice ...

journal_title：Cancer research

authors： Wang X,Cunningham M,Zhang X,Tokarz S,Laraway B,Troxell M,Sears RC

更新日期：2011-02-01 00:00:00

abstract：:Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial c...

journal_title：Cancer research

authors： Lau AT,Chiu JF

更新日期：2007-03-01 00:00:00

abstract：:The mechanism of action of the synthetic glucocorticoid antagonist, RU 38486, has yet to be completely elucidated. Although RU 38486 is a potent antiglucocorticoid in vivo, several studies have indicated that it has some agonist activities in vitro, such as high-affinity steroid binding to the receptor, activation, an...

journal_title：Cancer research

authors： Lindemeyer RG,Robertson NM,Litwack G

更新日期：1990-12-15 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone disease. Myeloma cells express the receptor activator of nuclear factor kappaB ligand (RANKL), induce RANKL expression in the bone marrow, and down-regulate express...

journal_title：Cancer research

authors： Heath DJ,Vanderkerken K,Cheng X,Gallagher O,Prideaux M,Murali R,Croucher PI

更新日期：2007-01-01 00:00:00

abstract：:PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell ...

journal_title：Cancer research

authors： Guise CP,Abbattista MR,Singleton RS,Holford SD,Connolly J,Dachs GU,Fox SB,Pollock R,Harvey J,Guilford P,Doñate F,Wilson WR,Patterson AV

更新日期：2010-02-15 00:00:00

abstract：:Degradation and invasion of basement membrane by tumor cells involves the cooperative hydrolysis of proteoglycans, collagens, and glycoproteins mediated by a number of enzymes including proteases, collagenases, and glycosidases. In order to study these processes in vitro, a tissue culture system was developed in which...

journal_title：Cancer research

authors： Woynarowska B,Wikiel H,Bernacki RJ

更新日期：1989-10-15 00:00:00

abstract：:Fifty-eight skin biopsies and three primary internal tumors from patients affected by the rare hereditary disease xeroderma pigmentosum (XP) were studied by an improved PCR-single strand conformation polymorphism analysis to detect the mutations of the tumor suppressor gene p53. The results from cutaneous XP tumors, i...

journal_title：Cancer research

authors： Giglia G,Dumaz N,Drougard C,Avril MF,Daya-Grosjean L,Sarasin A

更新日期：1998-10-01 00:00:00

abstract：:The XC infectious center assay was used to study the nature of the lymphoid cells producing N-tropic C-type viruses in preleukemic AKR mice. Viral production by thymic cell suspensions was very low and was possibly due to contaminating cells. Production at least 100-fold higher was found in spleen cells and was probab...

journal_title：Cancer research

authors： Gisselbrecht S,Blaineau C,Hurot MA,Pozo F,Levy JP

更新日期：1978-04-01 00:00:00

abstract：:To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), in 22 inflammation-related genes, in a population-based case-control study conducted in Shanghai, China, where the incidence of biliary...

journal_title：Cancer research

authors： Hsing AW,Sakoda LC,Rashid A,Andreotti G,Chen J,Wang BS,Shen MC,Chen BE,Rosenberg PS,Zhang M,Niwa S,Chu L,Welch R,Yeager M,Fraumeni JF Jr,Gao YT,Chanock SJ

更新日期：2008-08-01 00:00:00

abstract：:The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-choline positron emiss...

journal_title：Cancer research

authors： Wehrl HF,Schwab J,Hasenbach K,Reischl G,Tabatabai G,Quintanilla-Martinez L,Jiru F,Chughtai K,Kiss A,Cay F,Bukala D,Heeren RM,Pichler BJ,Sauter AW

更新日期：2013-03-01 00:00:00

abstract：:We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by means of their effects on mitotic spindle microtubules or by another mechanism or by a combination of mechanisms. Five Vinca alkaloids were used to investigate the relationship in HeLa cells be...

journal_title：Cancer research

authors： Jordan MA,Thrower D,Wilson L

更新日期：1991-04-15 00:00:00

abstract：:The in vitro cytotoxicities of the four drugs most frequently used for intravesical chemotherapy (Adriamycin, epodyl, mitomycin C, Thiotepa) and epirubicin were compared using monolayers and multicellular tumor spheroids of the human bladder cancer cell line, MGH-U1. Adriamycin and epirubicin were most cytotoxic again...

journal_title：Cancer research

authors： Knuchel R,Hofstadter F,Jenkins WE,Masters JR

更新日期：1989-03-15 00:00:00

abstract：:Cultured explants of mouse mammary gland were investigated for their capacity to secrete a cathepsin B-like cysteine proteinase. This enzyme had been shown previously to be secreted excessively from cultured explants of human breast tumors and spontaneous mouse mammary carcinomas. We now show that secretion is also ob...

journal_title：Cancer research

authors： Recklies AD,White C,Mitchell J,Poole AR

更新日期：1985-05-01 00:00:00

abstract：:Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is known regarding the mechanisms by which the expression of this gene can be repressed. Here, we show that activating and repressive E2Fs simultaneously bind the BRCA...

journal_title：Cancer research

authors： Bindra RS,Gibson SL,Meng A,Westermark U,Jasin M,Pierce AJ,Bristow RG,Classon MK,Glazer PM

更新日期：2005-12-15 00:00:00

abstract：:Hypoxia initiates numerous intracellular signaling pathways important in regulating cell proliferation, differentiation, and death. In this study, we investigated the pathway that hypoxia uses to activate Akt and inactivate glycogen synthase kinase-3 (GSK-3), two proteins the functions of which are important in cell s...

journal_title：Cancer research

authors： Chen EY,Mazure NM,Cooper JA,Giaccia AJ

更新日期：2001-03-15 00:00:00

abstract：:Peroxisome proliferators (PPs) act as nongenotoxic tumor promoters in rodents. Their hepatocarcinogenicity requires the presence of the PP-activated receptor alpha (PPARalpha); however, the exact role played by this transcription factor in the liver, more precisely in liver cell growth and differentiation, is not know...

journal_title：Cancer research

authors： Kaplanski C,Pauley CJ,Griffiths TG,Kawabata TT,Ledwith BJ

更新日期：2000-02-01 00:00:00

abstract：:The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. The hybrid cells were produced by fusion of a normal and tumor cell. The parental lines...

journal_title：Cancer research

authors： Sanford KK,Parshad R,Stanbridge EJ,Frost JK,Jones GM,Wilkinson JE,Tarone RE

更新日期：1986-04-01 00:00:00

abstract：:About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 c...

journal_title：Cancer research

authors： Kemp ZE,Carvajal-Carmona LG,Barclay E,Gorman M,Martin L,Wood W,Rowan A,Donohue C,Spain S,Jaeger E,Evans DG,Maher ER,Bishop T,Thomas H,Houlston R,Tomlinson I,Colorectal Tumour Gene Identification Study Consortium.

更新日期：2006-05-15 00:00:00

abstract：:Continuous cell lines are widely used, but can result in invalid, irreproducible research data. Cell line misidentification is a common problem that can be detected by authentication testing; however, misidentified cell lines continue to be used in publications. Here we explore the impact of one misidentified cell lin...

journal_title：Cancer research

authors： Vaughan L,Glänzel W,Korch C,Capes-Davis A

更新日期：2017-06-01 00:00:00

abstract：:Reactive oxygen species play a critical role in the onset of apoptosis induced by various extracellular stimuli, including ionizing radiation. Therefore active regulation of reactive oxygen species-metabolizing enzymes may be one response to an apoptotic stimulus. In this regard, HP100 cells, H(2)O(2)-resistant varian...

journal_title：Cancer research

authors： Nenoi M,Ichimura S,Mita K,Yukawa O,Cartwright IL

更新日期：2001-08-01 00:00:00

abstract：:2'-Deoxycoformycin (2'-dCF), a tight-binding inhibitor of adenosine deaminase, was administered to 26 pediatric patients with acute lymphoblastic leukemia in a Phase I study. Doses ranged from 0.25 to 1.0 mg/kg given i.v. for 3 consecutive days. Common toxicity included nausea, vomiting, diarrhea, hepatocellular enzym...

journal_title：Cancer research

authors： Poplack DG,Sallan SE,Rivera G,Holcenberg J,Murphy SB,Blatt J,Lipton JM,Venner P,Glaubiger DL,Ungerleider R,Johns D

更新日期：1981-09-01 00:00:00

abstract：:Pancreatic cancer is an aggressive neoplasm with no current viable, effective treatment options. In the majority of cases, at first diagnosis, pancreatic cancer has already become metastatic so that conventional treatment regimens provide minimal, if any, clinical benefit in prolonging life or ameliorating the negativ...

journal_title：Cancer research

authors： Sarkar D,Su ZZ,Vozhilla N,Park ES,Randolph A,Valerie K,Fisher PB

更新日期：2005-10-01 00:00:00