Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny.

abstract：:Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder caused by mutations at the NF2 gene locus. Merlin, the protein product of the NF2 gene, has been shown to negatively regulate Rac1 signaling by inhibiting its downstream effector kinases, the p21-activated kinases (Pak). Given the implication of ...

journal_title：Cancer research

authors： Yi C,Wilker EW,Yaffe MB,Stemmer-Rachamimov A,Kissil JL

更新日期：2008-10-01 00:00:00

abstract：:We compared the effect of nine N-nitroso compounds, given by gavage to adult rats, on specific radioactivity of the trichloroacetic acid-precipitable liver proteins, 1 hr after the injection of [14C]leucine. The specific radioactivity was decreased by dimethylnitrosamine, diethylnitrosamine, methyl-n-butylnitrosamine,...

journal_title：Cancer research

authors： Chu C,Mirvish SS

更新日期：1977-05-01 00:00:00

abstract：:Monoclonal antibodies (mAb) are widely used in the treatment of non-Hodgkin's lymphoma and autoimmune diseases. Although the mechanism of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on the binding of the Fcgamma regions to low-affinity Fcgamma receptors (FcgammaR) expr...

journal_title：Cancer research

authors： Stavenhagen JB,Gorlatov S,Tuaillon N,Rankin CT,Li H,Burke S,Huang L,Vijh S,Johnson S,Bonvini E,Koenig S

更新日期：2007-09-15 00:00:00

abstract：:Two characteristics of immune responses to weakly immunogenic plasma cell tumors were demonstrated in this study. (a) Elevated lymphoproliferative responses following in vivo inoculation of sublethal doses of plasma cell tumors were detected by a mixed lymphocyte-tumor interaction (MLTI) assay. Specificity of elevated...

journal_title：Cancer research

authors： Boyer PJ,Fahey JL

更新日期：1976-04-01 00:00:00

abstract：:To analyze the humoral immune response to melanoma, human-mouse hybridomas were generated by the fusions of regional lymph node lymphocytes of patients with the mouse myeloma cell line M5. Six stable hybridomas were cloned from six separate lymphocyte parents obtained from three patients. Ascites were obtained from nu...

journal_title：Cancer research

authors： Kan-Mitchell J,Imam A,Kempf RA,Taylor CR,Mitchell MS

更新日期：1986-05-01 00:00:00

abstract：:We have analyzed the mechanism of activation of two human ras oncogenes. We have also identified a rasN gene from a human gastric adenocarcinoma which efficiently induced both morphological transformation and tumorigenicity of NIH3T3 cells in a transfection assay. The rasN gene in tumor tissue DNA did not appear to be...

journal_title：Cancer research

authors： O'Hara BM,Oskarsson M,Tainsky MA,Blair DG

更新日期：1986-09-01 00:00:00

abstract：:A common form of multidrug resistance in human cancer results from expression of the MDR1 gene which encodes a plasma membrane energy-dependent multidrug efflux pump. We have engineered transgenic mice which express this multidrug transporter in their bone marrow cells and demonstrated that peripheral WBC of these ani...

journal_title：Cancer research

authors： Mickisch GH,Licht T,Merlino GT,Gottesman MM,Pastan I

更新日期：1991-10-01 00:00:00

abstract：:A low molecular weight cytoplasmic protein (Mr 19,000-22,000) has been reported to be overexpressed in some multidrug-resistant cells. We have found that a cytoplasmic protein with a molecular weight of 22,000 is highly expressed in the human myelogenous leukemia K562 cells resistant to Adriamycin (K562/ADM). The Mr 2...

journal_title：Cancer research

authors： Hamada H,Okochi E,Oh-hara T,Tsuruo T

更新日期：1988-06-01 00:00:00

abstract：:The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitou...

journal_title：Cancer research

authors： Kikuchi T,Rempel SA,Rutz HP,de Tribolet N,Mulligan L,Cavenee WK,Jothy S,Leduy L,Van Meir EG

更新日期：1993-03-01 00:00:00

abstract：:One-week-old male and female mice of the A, BALB/c (C), and C3H/He (C3) strains and of the AC3 and CC3 F1 hybrids were treated with a single dose (300 mg/kg s.c.) of urethan and then kept without further treatment until 30 and 40 weeks (males) or 30 and 65 weeks (females). The degree of difference in susceptibility to...

journal_title：Cancer research

authors： Dragani TA,Manenti G,Della Porta G

更新日期：1991-12-01 00:00:00

abstract：:Chromosomal aberrations associated with lung cancer are frequently observed in the long arm of chromosome 6. A candidate susceptibility locus at 6q23-25 for lung cancer was recently identified; however, no tumor suppressor genes inactivated by mutation have been identified in this locus. Genetic, epigenetic, gene expr...

journal_title：Cancer research

authors： Tessema M,Willink R,Do K,Yu YY,Yu W,Machida EO,Brock M,Van Neste L,Stidley CA,Baylin SB,Belinsky SA

更新日期：2008-03-15 00:00:00

abstract：:The high uptake and prolonged renal retention of monoclonal antibody fragments that are conjugated with radiometal chelates precludes their routine clinical use due to high background counts, which may hinder detection of nearby lesions and/or cause renal radiotoxicity. We report on the potential use of Lys as a pharm...

journal_title：Cancer research

authors： DePalatis LR,Frazier KA,Cheng RC,Kotite NJ

更新日期：1995-11-15 00:00:00

abstract：:We have previously shown that treatment of C57BL/6 mice with specific anti-B16 melanoma monoclonal antibody (Mab) significantly reduced the number of established liver metastases. In this paper we show that when treatment with Mab was applied to mice bearing both liver and lung micrometastases, the number of liver met...

journal_title：Cancer research

authors： Eisenthal A,Cameron RB,Uppenkamp I,Rosenberg SA

更新日期：1988-12-15 00:00:00

abstract：:Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The expression of claudin-1, activity ...

journal_title：Cancer research

authors： Oku N,Sasabe E,Ueta E,Yamamoto T,Osaki T

更新日期：2006-05-15 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an aggressive clinical course, whereas others having an indolent behavior. We conducted an integrative and multidisciplinary analysis of 177 MCL to determine whether the immunogenetic features of the clonotypic B-cell receptors (BcR) ma...

journal_title：Cancer research

authors： Navarro A,Clot G,Royo C,Jares P,Hadzidimitriou A,Agathangelidis A,Bikos V,Darzentas N,Papadaki T,Salaverria I,Pinyol M,Puig X,Palomero J,Vegliante MC,Amador V,Martinez-Trillos A,Stefancikova L,Wiestner A,Wilson W,Po

更新日期：2012-10-15 00:00:00

abstract：:Tissues from 22 patients with glioma and 7 patients with normal white matter were used in this study. First we determined the proliferating area in the tumor tissue by evaluating the growth fraction (GF). Second we determined the mean number of cells and measured the intercapillary distance in a modified tumor cord in...

journal_title：Cancer research

authors： Yoshii Y,Sugiyama K

更新日期：1988-05-15 00:00:00

abstract：:Blood tests to detect circulating tumor cells (CTC) offer great potential to monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For patients with brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell s...

journal_title：Cancer research

authors： Macarthur KM,Kao GD,Chandrasekaran S,Alonso-Basanta M,Chapman C,Lustig RA,Wileyto EP,Hahn SM,Dorsey JF

更新日期：2014-04-15 00:00:00

abstract：:Cell division cycle 25B (Cdc25B) phosphatase controls entry into mitosis and regulates recovery from G2-M checkpoint-induced arrest. In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in...

journal_title：Cancer research

authors： Srivastava SK,Bansal P,Oguri T,Lazo JS,Singh SV

更新日期：2007-10-01 00:00:00

abstract：:An extract of a human cervical squamous carcinoma was used to produce rabbit antiserum with immunoreactivity against an antigen in several types of normal and neoplastic tissues. This antigen was abundant in cervical cancer as well as in normal adult and fetal kidney and liver. The antigen had a beta mobility in immun...

journal_title：Cancer research

authors： Goldenberg DM,Garner TF,Pant KD,van Nagell JR Jr

更新日期：1978-05-01 00:00:00

abstract：:The carcinogenic effectiveness of a number of nitrosoalkylamides related to nitrosoethylurea and nitroso-n-propylurea has been compared by topical application to Swiss mice and by intragastric administration to F344 rats. Nitrosohydroxyethylurea and the related cyclic nitrosamide, nitrosooxazolidone, were as potent as...

journal_title：Cancer research

authors： Lijinsky W,Reuber MD

更新日期：1983-01-01 00:00:00

abstract：:Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including those with increased and decreased choline metabolism as measured by the tissue upt...

journal_title：Cancer research

authors： Kwee SA,Tiirikainen M,Sato MM,Acoba JD,Wei R,Jia W,Le Marchand L,Wong LL

更新日期：2019-04-01 00:00:00

abstract：:Human polymorphic N-acetyltransferase (NAT2) catalyzes the N-acetylation of arylamine carcinogens and the metabolic activation of N-hydroxyarylamine and N-hydroxyarylamide carcinogens by O- and N,O-acetylation, respectively. Rapid and slow acetylator phenotype is regulated at the NAT2 locus, and each has been associat...

journal_title：Cancer research

authors： Hein DW,Doll MA,Rustan TD,Ferguson RJ

更新日期：1995-08-15 00:00:00

abstract：:The effect of the prostaglandin synthetase inhibitor indomethacin on the dietary fat enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis has been examined in female Sprague-Dawley rats. Rats were fed either a normal-fat or high-fat diet (5 or 18% corn oil, respectively) with or without 0.004% i...

journal_title：Cancer research

authors： Carter CA,Milholland RJ,Shea W,Ip MM

更新日期：1983-08-01 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and express...

journal_title：Cancer research

authors： Ono M,Handa K,Withers DA,Hakomori S

更新日期：1999-05-15 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). However, the functional impact of ADAMTS9 on cancer development has not been explored. In this study, we eval...

journal_title：Cancer research

authors： Lo PH,Lung HL,Cheung AK,Apte SS,Chan KW,Kwong FM,Ko JM,Cheng Y,Law S,Srivastava G,Zabarovsky ER,Tsao SW,Tang JC,Stanbridge EJ,Lung ML

更新日期：2010-07-01 00:00:00

abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:The ability of four steroids and three bile acids to promote the appearance of hyperplastic foci and hyperplastic nodules initiated by diethylnitrosamine (DEN) in the liver of male Fischer rats was tested and compared with that of the known promoter phenobarbital (PB, 0.05%) as a standard value. Two weeks after a sing...

journal_title：Cancer research

authors： Cameron RG,Imaida K,Tsuda H,Ito N

更新日期：1982-06-01 00:00:00