Abstract：
:The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitous in human cancer, including colon carcinoma and gliomas, and (b) somatic or germ line mutations of the p53 tumor suppressor gene cause the Li-Fraumeni syndrome, which is characterized by the association of breast and soft tissue tumors. We determined the DNA sequence of the conserved regions of the p53 gene (exons 5 to 9) in the tumor tissues and lymphocytes of two patients with glioma-polyposis and found that mutations did occur as independent tumor-specific alterations but did not involve the germ line of these patients, suggesting that p53 may play a role in progression but not initiation of the disease.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kikuchi T,Rempel SA,Rutz HP,de Tribolet N,Mulligan L,Cavenee WK,Jothy S,Leduy L,Van Meir EGsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
957-61issue
5eissn
0008-5472issn
1538-7445journal_volume
53pub_type
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