miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer.

abstract：:We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

journal_title：Cancer research

authors： Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

更新日期：1998-12-15 00:00:00

abstract：:Transgenic mice have been previously established that express v-rasHa or v-fos exclusively in the epidermis by means of a targeting vector based on the human keratin 1 gene (HK1). Epidermal expression of v-rasHa (HK1.ras) or v-fos (HK1.fos) resulted in hyperplasia, hyperkeratosis, and later, in benign tumors. To asses...

journal_title：Cancer research

authors： Greenhalgh DA,Quintanilla MI,Orengo CC,Barber JL,Eckhardt JN,Rothnagel JA,Roop DR

更新日期：1993-11-01 00:00:00

abstract：:The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. Cyclin D2 was found to be amplified in one tumor and cyclin E in another. In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. Cyclin D1, previously shown to be amplified in ...

journal_title：Cancer research

authors： Leach FS,Elledge SJ,Sherr CJ,Willson JK,Markowitz S,Kinzler KW,Vogelstein B

更新日期：1993-05-01 00:00:00

abstract：:We have used photoaffinity labeling to investigate the distribution and function of daunomycin binding sites in Sarcoma 180 cells. When native daunomycin is irradiated at 366 or 488 nm in the presence of cells, the drug is irreversibly incorporated into cellular molecules. The cellular acceptor for the photoincorporat...

journal_title：Cancer research

authors： Yee G,Carey M,Tritton TR

更新日期：1984-05-01 00:00:00

abstract：:Disruption of one allele for the cytosine-DNA methyltransferase 1 (DNMT1) gene in mice with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor formation in juvenile animals. This effect is now reproduced in our studies of mature mice where this genetic DNMT1 reduction leads to a 50% d...

journal_title：Cancer research

authors： Belinsky SA,Klinge DM,Stidley CA,Issa JP,Herman JG,March TH,Baylin SB

更新日期：2003-11-01 00:00:00

abstract：:Chemotherapy, radiation, and growth inhibitory drugs preferentially eliminate actively growing cancer cells. Cancer recurrence is currently thought to be due to nondividing cancer stem/progenitor cells that are resistant to these therapies. Different therapeutic approaches need to be considered for the elimination of ...

journal_title：Cancer research

authors： Engelmann K,Shen H,Finn OJ

更新日期：2008-04-01 00:00:00

abstract：:On the basis of reports of rat mammary- and pancreas-tumor models, we hypothesized that an increase in consumption of linoleic acid (LA) would also cause an enhancement in mouse skin-tumor promotion. SEN-CAR mice were placed on diets containing 0.8%, 2.2%, 3.5%, 4.5%, 5.6%, 7.0%, or 8.4% LA, 1 week after initiation wi...

journal_title：Cancer research

authors： Fischer SM,Leyton J,Lee ML,Locniskar M,Belury MA,Maldve RE,Slaga TJ,Bechtel DH

更新日期：1992-04-01 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Both Src kinase and membrane type 1 matrix metalloproteinase (MT1-MMP) play critical roles in cancer invasion and metastasis. It is not clear, however, how the spatiotemporal activation of these two critical enzymes is coordinated in response to an oncogenic epithelial growth factor (EGF) stimulation. Here, we have vi...

journal_title：Cancer research

authors： Ouyang M,Huang H,Shaner NC,Remacle AG,Shiryaev SA,Strongin AY,Tsien RY,Wang Y

更新日期：2010-03-15 00:00:00

abstract：:We reported previously that 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, markedly enhanced methylcholanthrene-induced transformation of BALB 3T3 A31-1-1 cells. When the cells were treated with methylcholanthrene (1 microgram/ml) for 72 h and then with 1 alpha,25(OH)2D3 (5...

journal_title：Cancer research

authors： Sasaki K,Chida K,Hashiba H,Kamata N,Abe E,Suda T,Kuroki T

更新日期：1986-02-01 00:00:00

abstract：:Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover. Nonetheless, we show here that, in mutant is...

journal_title：Cancer research

authors： Viswanath P,Radoul M,Izquierdo-Garcia JL,Ong WQ,Luchman HA,Cairncross JG,Huang B,Pieper RO,Phillips JJ,Ronen SM

更新日期：2018-05-01 00:00:00

abstract：:Endometrial carcinoma is associated with antecedent simple and complex hyperplasia, and the endometrium is a target tissue for the action of cytokines and growth factors. Transforming growth factor (TGF)-beta s are potent cellular growth and differentiation regulatory factors. Therefore, we investigated the potential ...

journal_title：Cancer research

authors： Gold LI,Saxena B,Mittal KR,Marmor M,Goswami S,Nactigal L,Korc M,Demopoulos RI

更新日期：1994-05-01 00:00:00

abstract：:Possible mechanisms whereby alcohol abuse and alcohol-related diseases may promote the development of cancer are analyzed. The mechanisms discussed include: (a) contact-related local effects on the upper gastrointestinal tract; (b) the presence of low levels of carcinogens in alcoholic beverages; (c) induction of micr...

journal_title：Cancer research

authors： Lieber CS,Seitz HK,Garro AJ,Worner TM

更新日期：1979-07-01 00:00:00

abstract：:Phenobarbital (PB), a classical rodent hepatopromoter, remarkably enhances hepatocarcinogenesis initiated by diethylnitrosamine (DEN) in adult B6C3F1 mice. However, it is also known to strongly inhibit liver tumor development in the B6C3F1 mice initiated with DEN in their infancy. The present study aimed to elucidate ...

journal_title：Cancer research

authors： Lee GH,Ooasa T,Osanai M

更新日期：1998-04-15 00:00:00

abstract：:The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after incorporation of gemcitabine nucleotide at either the 3'-terminal or ...

journal_title：Cancer research

authors： Gandhi V,Legha J,Chen F,Hertel LW,Plunkett W

更新日期：1996-10-01 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) has long been recognized as the major proliferative and functional stimulus for thyroid follicular cells. TSH receptor (TSHR) engagement stimulates the production of cyclic AMP and the subsequent activation of downstream effector molecules, including protein kinase A, S6K1, and Rap1, ...

journal_title：Cancer research

authors： Brewer C,Yeager N,Di Cristofano A

更新日期：2007-09-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effect...

journal_title：Cancer research

authors： Stemke-Hale K,Gonzalez-Angulo AM,Lluch A,Neve RM,Kuo WL,Davies M,Carey M,Hu Z,Guan Y,Sahin A,Symmans WF,Pusztai L,Nolden LK,Horlings H,Berns K,Hung MC,van de Vijver MJ,Valero V,Gray JW,Bernards R,Mills GB,Hennes

更新日期：2008-08-01 00:00:00

abstract：:To study the influence of reflux esophagitis on the carcinogenic response of 2,6-dimethylnitrosomorpholine (2,6-DMNM), an experiment was designed, composed of 6 groups of 8-week-old Sprague-Dawley rats, each consisting of 20 males and 20 females. Group 1 served as untreated controls. All animals of groups 2, 4, and 6 ...

journal_title：Cancer research

authors： Pera M,Cardesa A,Bombi JA,Ernst H,Pera C,Mohr U

更新日期：1989-12-01 00:00:00

abstract：:Lymphocytes isolated from the peripheral blood of patients with nonmalignant and malignant disorders were studied for fluidity of membrane lipids and lateral mobility of concanavalin A (Con A) receptors. The degree of fluidity of the surface membrane lipid core was monitored quantitatively by fluorescence polarization...

journal_title：Cancer research

authors： Ben-Bassat H,Polliak A,Rosenbaum SM,Naparstek E,Shouval D,Inbar M

更新日期：1977-05-01 00:00:00

abstract：:Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still...

journal_title：Cancer research

authors： Fujita-Sato S,Galeas J,Truitt M,Pitt C,Urisman A,Bandyopadhyay S,Ruggero D,McCormick F

更新日期：2015-07-15 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days lat...

journal_title：Cancer research

authors： Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

更新日期：2011-07-15 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:Tumorigenesis in humans and experimental animals appears to involve the activation of ras protooncogenes for a number of organ systems and seems to be important to the development of the metastatic phenotype in several model systems. Clinically, the presence of activated ras protooncogenes has been reported to be a ne...

journal_title：Cancer research

authors： Mizuuchi H,Nasim S,Kudo R,Silverberg SG,Greenhouse S,Garrett CT

更新日期：1992-05-15 00:00:00

abstract：:We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucida...

journal_title：Cancer research

authors： Harrison H,Farnie G,Brennan KR,Clarke RB

更新日期：2010-11-15 00:00:00

abstract：:The hyperthermic sensitivity of cultured human glioblastoma cells was determined in 1 degree increments from 42 through 46 degrees over the pH range of 6.1 to 7.4. These cells were 5 to 10 times less heat sensitive than were Chinese hamster ovary cells and are among the most resistant cells examined in cell culture. A...

journal_title：Cancer research

authors： Gerweck LE,Richards B

更新日期：1981-03-01 00:00:00

abstract：:Increased activity, membrane association, and secretion of cathepsin B have been shown to correlate positively with invasiveness and the metastatic properties of many tumor entities. Cathepsin B is able to directly facilitate invasion by degrading extracellular matrix components or to indirectly facilitate invasion by...

journal_title：Cancer research

authors： Krueger S,Haeckel C,Buehling F,Roessner A

更新日期：1999-12-01 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt th...

journal_title：Cancer research

authors： Shiftan L,Israely T,Cohen M,Frydman V,Dafni H,Stern R,Neeman M

更新日期：2005-11-15 00:00:00

abstract：:A prominent feature of glioblastoma is its resistance to death from Fas pathway activation. In this study, we explored the modulation of Fas-induced glioblastoma death with chemotherapeutic agents. Camptothecin significantly increased the glioblastoma cell death response to Fas receptor activation regardless of p53 st...

journal_title：Cancer research

authors： Xia S,Rosen EM,Laterra J

更新日期：2005-06-15 00:00:00