Abstract:
:Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days later by intrahippocampal transplantation with human neural stem cells (hNSC). Measures of cognitive performance, hNSC survival, and phenotypic fate were assessed at 1 and 4 months after irradiation. Irradiated animals engrafted with hNSCs showed significantly less decline in cognitive function than irradiated, sham-engrafted animals and acted indistinguishably from unirradiated controls. Unbiased stereology revealed that 23% and 12% of the engrafted cells survived 1 and 4 months after transplantation, respectively. Engrafted cells migrated extensively, differentiated along glial and neuronal lineages, and expressed the activity-regulated cytoskeleton-associated protein (Arc), suggesting their capability to functionally integrate into the hippocampus. These data show that hNSCs afford a promising strategy for functionally restoring cognition in irradiated animals.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CLdoi
10.1158/0008-5472.CAN-11-0027subject
Has Abstractpub_date
2011-07-15 00:00:00pages
4834-45issue
14eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-11-0027journal_volume
71pub_type
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