Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction.

Abstract:

:Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days later by intrahippocampal transplantation with human neural stem cells (hNSC). Measures of cognitive performance, hNSC survival, and phenotypic fate were assessed at 1 and 4 months after irradiation. Irradiated animals engrafted with hNSCs showed significantly less decline in cognitive function than irradiated, sham-engrafted animals and acted indistinguishably from unirradiated controls. Unbiased stereology revealed that 23% and 12% of the engrafted cells survived 1 and 4 months after transplantation, respectively. Engrafted cells migrated extensively, differentiated along glial and neuronal lineages, and expressed the activity-regulated cytoskeleton-associated protein (Arc), suggesting their capability to functionally integrate into the hippocampus. These data show that hNSCs afford a promising strategy for functionally restoring cognition in irradiated animals.

journal_name

Cancer Res

journal_title

Cancer research

authors

Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

doi

10.1158/0008-5472.CAN-11-0027

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

4834-45

issue

14

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-11-0027

journal_volume

71

pub_type

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